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| 1 | 高级别胶质瘤放、化疗耐药性可能与microRNAs相关(英文)显示文摘High-grade gliomas(HGGs) are malignant primary brain tumors of glial cell origin.Despite optimal course of treatment,including maximal surgical resection followed by adjuvant chemo-and/or radiotherapy,the prognosis still remains poor.The main reason is the commonly occurring chemo-and radioresistance of these tumors.In recent years,several signaling pathways,especially PI3K/AKT and ATM/CHK2/p53,have been linked to the resistance of gliomas.Moreover,additional studies have shown that these pathways are significantly regulated by microRNAs(miRNAs),short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis,proliferation,cell cycle,invasivity,and angiogenesis.MiRNAs are not only highly deregulated in gliomas,their expression signatures have also been shown to predict prognosis and therapy response.Therefore,they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients.In this review,we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo-and radiotherapy. | Besse A Sana J Fadrus P Slaby O | 2013 | 中华神经外科疾病研究杂志2013，12，2： | 3 |
| 2 | Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance显示文摘 | Kubiczkova L Kryukov F Slaby O | 2014 | Haematologica2014，99，： | 1 |
| 3 | Altered expression of MIR-21,miR-31,miR143 and miR-145 is related to clinicopathologic features of colorectal cancer显示文摘 | Slaby O Svoboda M Fabian P | | 0，，： | 1 |
| 4 | Altered expression of miR- 21 ,miR-31 ,miR-143 and miR-145 is related to clinico- pathologic features of colorectal cancer 显示文摘 | Slaby O Svoboda M Fabian P | 2007 | Oncology2007，72，56： | 1 |
| 5 | Gene expression of somatostatin receptor 4 predicts clinical outcome of patients with metastatic neuroendocrine tumors treated with somatostatin analogs 显示文摘 | Slaby O Sachlova M Bednarikova M | 2010 | Cancer Biother Radiopharm2010，25，2： | 1 |
| 6 | Altered Expression of miR-21,miR-31,miR-143 and miR-145 Is Related to Clinico-pathologic Features of Colorectal Cancer显示文摘 | Slaby O Svoboda M Fabian P | | 0，，06： | 1 |
| 7 | Altered expression of miR-21, miR-31, miR- 143 andmiR-145 is related to clinicopathologic features of colorectal cancer显示文摘 | Slaby O Svoboda M | 2007 | Oncology2007，72，1： | 1 |
| 8 | MicroRNA-342,microRNA-191 and microBNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients显示文摘 | Hezova R Slaby O Faltejskova P | 2010 | Cell Immunol2010，260，2： | 1 |
| 9 | Expression of miRNA-106h in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy 显示文摘 | Slaby O Jancovicova J Lakomy R | 2010 | J Exp Clin Cancer Res2010，29，： | 1 |
| 10 | Altered expression of miR-21,miR-31,miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer显示文摘 | Slaby O Svoboda M Fabian P | | 0，，5： | 1 |
| 11 | Altered expression of mir-21,Mir-31,Mir-143and mir-145is related to clini-copathologic features of colorectal cancer显示文摘 | Slaby O Svoboda M Fabian P | | 0，，： | 1 |
| 12 | Phase tracking and restoration of circadian rhythms by model-based optimal control显示文摘 | Shaik O S Sager S Slaby O | 2008 | IET Syst Bio12008，2，1： | 1 |
| 13 | Altered expression of miR-21, miR-31, miR-143 and miR-lg5 is related to clinicopathologic features of colorectal cancer显示文摘 | Slaby O Svoboda M Fabian P | 2007 | Oncology2007，72，56： | 1 |
| 14 | Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients显示文摘 | Slaby O Redova M Poprach A | | 0，，07： | 1 |
| 15 | Altered expression of miR- 21, miR-31, miR-143 and miR-145 is related to clinieopathologie features of coloreetal eaneer显示文摘 | Slaby O Svoboda M Fabian P | 2007 | Oncology2007，72，56： | 1 |
| 16 | Altered expression of miR-21,miR-31,miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer显示文摘 | Slaby O Svoboda M Fabian P | 2007 | Oncology2007，72，56： | 1 |
| 17 | MicroRNA involvement inglioblastoma pathogenesis显示文摘 | Novakova J Slaby O Vyzula R | 2009 | Biochem Biophys Res Commun2009，386，1： | 1 |
| 18 | MicroRNAs in eolorec- tal cancer:translation of molecular biology into clinical appli- cation 显示文摘 | Slaby O Svoboda M Michalek J | 2009 | Mol Cancer2009，8，： | 1 |
| 19 | MicroRNAs in colorectal cancer: translation of molecular biology into clinical application显示文摘 | Slaby O Svoboda M Michalek J | 2009 | Mol Cancer2009，8，： | 1 |
| 20 | Expression of miR- NA-106b in conventional renal cell carcinoma is a potential mark- er for predictionof early metastasis after nephrectomy显示文摘 | Slaby O Jancovicova J Lakomy R | 2010 | J Exp Clin Cancer Res2010，7，： | 1 |
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