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9篇 您的检索式：作者名="SLIMANI R"

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		题名	作者	年代	出处	被引量
	1	Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr-Cas9显示文摘Background: Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis(CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and airway characteristics, including the presence of submucosal glands.Methods: We describe the generation of a CF rat model(F508 del) homozygous for the p.Phe508 del mutation in the transmembrane conductance regulator(Cftr) gene. This model was compared to new Cftr-/-rats(CFTR KO). Target organs in CF were examined by histological staining of tissue sections and tooth enamel was quantified by micro-computed tomography. The activity of CFTR was evaluated by nasal potential difference(NPD) and short-circuit current measurements. The effect of VX-809 and VX-770 was analyzed on nasal epithelial primary cell cultures from F508 del rats.Results: Both newborn F508 del and Knock out(KO) animals developed intestinal obstruction that could be partly compensated by special diet combined with an osmotic laxative. The two rat models exhibited CF phenotypic anomalies such as vas deferens agenesis and tooth enamel defects. Histology of the intestine, pancreas, liver, and lungs was normal. Absence of CFTR function in KO rats was confirmed ex vivo by short-circuit current measurements on colon mucosae and in vivo by NPD, whereas residual CFTR activity was observed in F508 del rats. Exposure of F508 del CFTR nasal primary cultures to a combination of VX-809 and VX-770 improved CFTR-mediated Cl-transport.Conclusions: The F508 del rats reproduce the phenotypes observed in CFTR KO animals and represent a novel resource to advance the development of CF therapeutics.	Elise Dreano Marc Bacchetta Juliette Simonin Louise Galmiche Claire Usal Lotfi Slimani Jérémy Sadoine Laurent Tesson Ignacio Anegon Jean-Paul Concordet Aurélie Hatton Lucile Vignaud Danielle Tondelier Isabelle Sermet-Gaudelus Marc Chanson Charles-Henry Cottart	2019	Animal Models and Experimental Medicine2019，2，4：	3
	2	European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study: rationale, design and population characteristics 显示文摘	SLIMANI N KAAKS R FERRARI P	2002	Public Health Nutrition2002，6，5：	1
	3	Study of keyhole behavior for full penetrated Nd-YAG CW laser welding显示文摘	FABBRO R SLIMANI S COSTE F	2005	Journal of Physics D:Appllied Physics2005，38，：	1
	4	Assessment of the biosorption kinetic and thermodynamic for the removal of safranin dye from aqueous solutions using calcined mussel shells显示文摘	EL HADDAD M REGTI A SLIMANI R	2014	Journal of Industrial and Engineering Chemistry2014，20，2：	1
	5	Experimental study of the dynamical coupling between the induced vapour plume and the melt pool for Nd-Yag CW laser welding 显示文摘	FABBRO R SLIMANI S DOUDET I COSTE F BRIAND F	2006	J Phys D: Appl Phys2006，39，：	1
	6	Study of keyhole behaviour for full penetration Nd-Yag CW laser welding 显示文摘	FABBRO R SLIMANI S COSTE F BRIAND F	2005	J Phys D: Appl Phys2005，38，：	1
	7	Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition ( EPIC ) : an observational study 显示文摘	Bingham S A Day N E Luben R Ferrari P Slimani N Norat T Clavel-Chapelon F Kesse E Nieters A Boeing H Tjcnneland A Overvad K Martinez C Dorronsoro M Gonzalez C A Key T J Trichopoulou A Naska A Vineis P Tumino R Krogh V Bueno- De-Mesquita H B Peeters P H M Berglund G Hallmans G Lund E Skeie G Kaaks R Riboli E	2003	Lancet2003，361，9368：	1
	8	Study of Key hole Behaviour for Full Penetration Nd-Yag CW Laser Welding显示文摘	Fabbro R Slimani S Coste F	2005	Journal of Physics D: Applied Physics2005，38，12：	1
	9	Existence results for differential equations with fractional order and impulses显示文摘	Agarwal R P Benchohra M Slimani B A		0，，：	1

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