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| 1 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 2 | Phosphorus removal from wastewater by anaerobic-anoxic sequencing batch reactor显示文摘 | Kuba T Van Loosdrecht M C M Smolders G | 1993 | War Sci Tech1993，27，56： | 2 |
| 3 | A structured metabolic model for the anaerobic and aerobic stoichiometry and kinetics of the biological phosphorus removal process显示文摘 | G J F Smolders | 1995 | Biotechnology and Biocngineering1995，47，： | 1 |
| 4 | Bioligical phosphorus removal from wastewater by anaerobic-aerobic se- quencing batch reaetor显示文摘 | Kuba T Smolders G van Loosdreeht M C M | 1993 | 27(5-6) : 241-2421993，27，56： | 1 |
| 5 | The mechanism of formation of microporous or skinned membranes produced by immersion precipitation显示文摘 | Wijimans J G Baaij J P B Smolders C A | 1983 | J Membr Sci1983，14，： | 1 |
| 6 | Biological phosphorus removal from wastewater by anaerobic-anoxic sequencing batch reactor 显示文摘 | Kuba T Smolders G van Loosdrecht M C M | 1993 | Water Science and Technology1993，27，56： | 1 |
| 7 | Model of the anaerobic metabolism of the biological phosphorus removal process:stoichionetry and pH influence显示文摘 | Smolders G J F Van der Meij J Van Loosdrecht M C M | 1994 | Biotechnology and Bioengineering1994，43，： | 1 |
| 8 | Model of the anaerobic metabolism of the biological phosphorus removal process:stoichiometry and pH influence显示文摘 | Smolders G J F Der M V J Van Loodrecht M C M | 1994 | Biotechnol Bioeng1994，43，： | 1 |
| 9 | Sulphate - mediated iron limitation and eutrophication in aquatic ecosystems显示文摘 | Smolders A Roelofs J G M | 1993 | Aquat Bot1993，46，： | 1 |
| 10 | 显示文摘 | Wijmans J G Baaij J P B Smolders C A | 1983 | Journal of Mem brane Science1983，14，3： | 1 |
| 11 | Biological phosphorus, removal from wastewater by anaerobic - anoxic seqrencing batch reator 显示文摘 | KUBA T SMOLDERS G VAN LOOSDRECHT M C M | 1993 | Water Sci Technol1993，27，56： | 1 |
| 12 | Stoichiometric model of the aerobic metabolism of the biological phosphorus removal process 显示文摘 | Smolders G J F Van der Meij J Van Loosdrecht M C M | 1994 | Biotechnology Bioengineering1994，44，7： | 1 |
| 13 | Stoichiometric model of the aerobic metabolism of the biologicalphosphorus removal process显示文摘 | Smolders G van der Meij J van Loosdrecht M Heijnen J | 1994 | Biotechnology and Bioengineering1994，44，7： | 1 |
| 14 | A metabolic model for the biological phosphate removal processes 显示文摘 | Smolders G J F van Loosdrecht M C M Heijnen J J | 1995 | Water Sci Technol1995，31，2： | 1 |
| 15 | Sulphur immobilization and availability in soils assessed using isotope dilution显示文摘 | Nziguheba G Smolders E Merckx R | 2005 | Soil Biology & Biochemistry2005，37，： | 1 |
| 16 | Allelopathic inhibition of phytoplankton by exudates from Stratiotes aloides 显示文摘 | Mulderij G Mooij W M Smolders A J P | 2005 | Aquatic Botany2005，82，4： | 1 |
| 17 | Biological phosphorus removal from wastewater by anaerobic-anoxic sequencing batch reactor 显示文摘 | Kuba T Smolders G van Loosdrecht M C M | 1993 | Water Science & Technology1993，27，56： | 1 |
| 18 | Biological phosphorus removal from wastewater by anaerobic-anoxic sequencing batch reactor 显示文摘 | KUBA T SMOLDER G MCM V L | 1993 | Water Sci Technol1993，27，56： | 1 |
| 19 | Biological phosphorus removal from wastewater by anaerobicanoxic sequencing batch reactor显示文摘 | Kuba T Smolders G Van Loosdrecht M C M | 1993 | Water Sci Tech1993，27，56： | 1 |
| 20 | Biological phosphorus removal from waste water by anaerobic-anoxic sequencing batch reactor显示文摘 | Kuba T Smolders G van Loosdrecht M C M | 1993 | Wat Sci Tech1993，27，576： | 1 |
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