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| 1 | AU-rich element-binding proteins in colorectal cancer显示文摘Trans-acting factors controlling mRNA fate are critical for the post-transcriptional regulation of inflammation-related genes, as well as for oncogene and tumor suppressor expression in human cancers. Among them, a group of RNA-binding proteins called 'Adenylate-Uridylate-rich elements binding proteins'(AUBPs)control mRNA stability or translation through their binding to AU-rich elements enriched in the 3'UTRs of inflammation-and cancer-associated mRNA transcripts. AUBPs play a central role in the recruitment of target mRNAs into small cytoplasmic foci called Processing-bodies and stress granules(also known as P-body/SG). Alterations in the expression and activities of AUBPs and Pbody/SG assembly have been observed to occur with colorectal cancer(CRC)progression, indicating the significant role AUBP-dependent post-transcriptional regulation plays in controlling gene expression during CRC tumorigenesis.Accordingly, these alterations contribute to the pathological expression of many early-response genes involved in prostaglandin biosynthesis and inflammation,along with key oncogenic pathways. In this review, we summarize the current role of these proteins in CRC development. CRC remains a major cause of cancer mortality worldwide and, therefore, targeting these AUBPs to restore efficient post-transcriptional regulation of gene expression may represent an appealing therapeutic strategy. | Noémie Legrand Dan A Dixon Cyril Sobolewski | 2019 | World Journal of Gastrointestinal Oncology2019，11，2： | 7 |
| 2 | Stress granules in colorectal cancer:Current knowledge and potential therapeutic applications显示文摘Stress granules(SGs)represent important non-membrane cytoplasmic compartments,involved in cellular adaptation to various stressful conditions(e.g.,hypoxia,nutrient deprivation,oxidative stress).These granules contain several scaffold proteins and RNA-binding proteins,which bind to mRNAs and keep them translationally silent while protecting them from harmful conditions.Although the role of SGs in cancer development is still poorly known and vary between cancer types,increasing evidence indicate that the expression and/or the activity of several key SGs components are deregulated in colorectal tumors but also in pre-neoplastic conditions(e.g.,inflammatory bowel disease),thus suggesting a potential role in the onset of colorectal cancer(CRC).It is therefore believed that SGs formation importantly contributes to various steps of colorectal tumorigenesis but also in chemoresistance.As CRC is the third most frequent cancer and one of the leading causes of cancer mortality worldwide,development of new therapeutic targets is needed to offset the development of chemoresistance and formation of metastasis.Abolishing SGs assembly may therefore represent an appealing therapeutic strategy to re-sensitize colon cancer cells to anti-cancer chemotherapies.In this review,we summarize the current knowledge on SGs in colorectal cancer and the potential therapeutic strategies that could be employed to target them. | Noémie Legrand Dan A Dixon Cyril Sobolewski | 2020 | World Journal of Gastroenterology2020，26，35： | 4 |
| 3 | Wharton' s jelly as a reservoir of peptide growth factors显示文摘 | Sobolewski K MMkowski A Ba fi kowski E | 2005 | Placenta2005，26，10： | 1 |
| 4 | FGF bindingby extracellular matrix components of Wharton 's jelly显示文摘 | Malkowski A Sobolewski K Jaworski S | 2007 | Acta Biochim Pol2007，，2： | 1 |
| 5 | Ab Initio Studies on the Radiationless Decay Mechanisms of the Lowest Excited Singlet States of 9H-Adenine 显示文摘 | Perun S Sobolewski A L Domcke W | 2005 | J Am Chem Soc2005，127，： | 1 |
| 6 | FGF binding by extracellular matrix components of Wharton's jelly 显示文摘 | Malkowski A Sobolewski K Jaworski S | 2007 | Acta Biochim Pol2007，54，2： | 1 |
| 7 | Surface energy of growth and seeding side of free standing nanocrystalline diamond foils 显示文摘 | Sobolewski S Lodes M A Rosiwal S M | 2013 | Surface and Coatings Technology2013，232，： | 1 |
| 8 | The role of the Va157 amino - acid residue in the hinge Loop of the Human cystatin C conformational studies of the Beta2 - L1 -Beta3 segments of wild - type Human cystatin C and its mutants 显示文摘 | Rodziewicz - Motowidlo S Iwaszkiewicz J Sosnowska R Cza- plewska P Sobolewski E Szymanska A Stachowiak K Liwo A | 2009 | Biopolymers2009，91，： | 1 |
| 9 | Detec?tion efficiency of large-active-area NbN single-photon super?conducting detectors in the ultraviolet to near-infrared range显示文摘 | VEREVKIN A ZHANGJ SOBOLEWSKI R | 2002 | Applied Physics Letters2002，80，25： | 1 |
| 10 | Role of electron-driven proton-transfer processes in the excited-state de-activation of the adenine-thymine base pair显示文摘 | Perun S Sobolewski A L Domcke W | 2006 | J PhysChem A2006，110，29： | 1 |
| 11 | FGF binding by extracellular matrix components of Wharton's jelly显示文摘 | Malkowski A Sobolewski K Jaworski S | 2007 | Acta Biochim Pol2007，54，2： | 1 |
| 12 | Detection efficiency of large-active-area NbN single-photon superconducting detectors in the ultraviolet to near-infrared range显示文摘 | Verevkin A Zhang J Sobolewski R | 2002 | Appl Phys Lett2002，80，25： | 1 |
| 13 | Excited-state hydrogen detachment and hydrogentransfer driven by repulsivestates: a new para-digm for nonradiative decay in aromatic biomolecules显示文摘 | Sobolewski A L Domcke W Dedonder-Lardeux C etal | 2002 | Phys Chem Chem Phys2002，，4： | 1 |
| 14 | FGF binding by extracellular matrix components of Wharton 's jelly 显示文摘 | Malkowski A Sobolewski K Jaworski S | 2007 | Acta Biochim Pol2007，54，2： | 1 |
| 15 | In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells显示文摘 | Hacker A Marton LJ Sobolewski M | 2008 | Cancer Chemother Pharmacol2008，63，1： | 1 |
| 16 | FGF bindingby extra-celluar matrix components of Wharton ’ s jelly 显示文摘 | Malkowski A Sobolewski K Jaworski S | 2007 | Acta Biochim Pol2007，54，2： | 1 |
| 17 | Evaluation of enzymes involved in proteoglycan degradation in the wall of abdominal aortic aneurysms 显示文摘 | Kowalewski R Sobolewski K Malkowski A | 2006 | J Vasc Res2006，43，1： | 1 |
| 18 | 查看详情显示文摘 | Sobolewski M A Kim J H | | 0，，： | 1 |
| 19 | Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines 显示文摘 | Pledgie-Tracy A Sobolewski MD Davidson NE | 2007 | Mol Cancer Ther2007，6，3： | 1 |
| 20 | Technological tests of NOx catalytical reduction in process of solid fuels combustion 显示文摘 | SOBOLEWSKI A HRYCKO P | 2009 | Polish Journal of Environmental Studies2009，18，1： | 1 |
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