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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Terahertz Semiconductor Quantum Well Devices显示文摘For eventually providing terahertz science with compact and convenient devices,terahertz (1~10THz) quantum-well photodetectors and quantum-cascade lasers are investigated.The design and projected detector performance are presented together with experimental results for several test devices,all working at photon energies below and around optical phonons.Background limited infrared performance (BLIP) operations are observed for all samples (three in total),designed for different wavelengths.BLIP temperatures of 17,13,and 12K are achieved for peak detection frequencies of 9.7THz(31μm),5.4THz(56μm),and 3.2THz(93μm),respectively.A set of THz quantum-cascade lasers with identical device parameters except for doping concentration is studied.The δ-doping density for each period varies from 3.2×1010 to 4.8×1010cm-2.We observe that the lasing threshold current density increases monotonically with doping concentration.Moreover,the measurements for devices with different cavity lengths provide evidence that the free carrier absorption causes the waveguide loss also to increase monotonically.Interestingly the observed maximum lasing temperature is best at a doping density of 3.6×1010cm-2. | Liu H C Luo H Ban D Waichter M Song C Y Wasilewski Z R Buchanan M Aers G C SpringThorpe A J Cao J C Feng S L Williams B S Hu Q | 2006 | Journal of Semiconductors2006，27，4： | 2 |
| 3 | Resonant vibration behavior of Sn-Zn-Ag solder alloys显示文摘 | Song J M Lui T S Lan G F | 2004 | Journal of Alloys and Compounds2004，379，12： | 1 |
| 4 | Crystal structure of Argonaute and its implications for RISC slicer activity 显示文摘 | Song J J Smith S K Hannon G J | 2004 | Science2004，305，5689： | 1 |
| 5 | Thyroid hormone regulates earnitine pahnitoyl transferase I a gene expression through elements in the promoter and first intron 显示文摘 | Jansen M S Cook G A Song S L | 2000 | J Biol Chem2000，275，34： | 1 |
| 6 | Research and development of components geographic information system显示文摘 | SONG G F ZHONG E S | 1998 | Journal of Image and Graphics1998，3，4： | 1 |
| 7 | Evidence of independent origin of multiple tumors from prostate cancer patients显示文摘 | Cheng L Song S Y Pretlow T G | 1997 | J Natl Cancer Inst1997，90，： | 1 |
| 8 | Controlled release of doxorubicin from thermosensitive poly (organophosphazene) hydrogels 显示文摘 | Kang G D Cheon S H Song S C | 2006 | Int J Pharm2006，319，12： | 1 |
| 9 | The activation of Akt/PKB signaling pathway and cell survival 显示文摘 | Song G Ouyang G Bao S | 2005 | J Cell Mol Med2005，9，1： | 1 |
| 10 | Treatment of naphthalene-2-sulfonic acid from tannery wastewater by a granular activatedcarbon fixed bed inoculated with bacterial isolates Arthrobacterglobiformis and Comamonas testosteroni显示文摘 | Song Z Edwards S R Burns R G | | 0，，03： | 1 |
| 11 | Grenville-age orogenesis in the Qaidam-Qilian block:The link between South China and Tarim显示文摘 | Song S G Su L Li X H | 2012 | Precambrian Research2012，22，： | 1 |
| 12 | Discovery of the first series of small molecule I-ISN1 entry inhibitors 显示文摘 | Song G P Yang S Zhang W | 2009 | J Med Chem2009，52，23： | 1 |
| 13 | Adsorption behavior of metal-organic frameworks for methylene blue from aqueous solution显示文摘 | Lin S Song Z L Che G B | 2014 | Microporous and Mesoporous Materials2014，193，： | 1 |
| 14 | Mesoporous silica-immobilized aluminum chloride as a new catalyst system for the isopropylation of naphthalene显示文摘 | Zhao X S Lu G Q Song C | 2001 | Chem Commun2001，22，： | 1 |
| 15 | Carbon/Graphite Seal Materials Prepared from Mesocarbon Microbeads显示文摘 | Song Y Z Zhai G T Li G S | 2004 | Car- bon2004，42，： | 1 |
| 16 | A note on lowcorrelation zone signal sets显示文摘 | Gong G Golomb S W and Song H Y | 2007 | IEEE Transactions onInformation Theory2007，53，7： | 1 |
| 17 | Volatiles from Ficus hispida and their attractiveness to fig wasps 显示文摘 | Song Q S Yang D R Zhang G M | 2001 | l Chem Ecol2001，27，10： | 1 |
| 18 | The R0-type fuzzy logic metric space and an algorithm for solving fuzzy modus ponens显示文摘 | Wang G J Hui X J Song J S | | (to appear)0，，： | 1 |
| 19 | Huayu 40, a groundnut cuhivar developed through EMS mutagenesis 显示文摘 | Wang C T Wang X Z Tang Y Y Zhang J C Chen D X Xu J Z Yang X D Song G S Cui F G | 2011 | Journal of SAT Agricultural Research2011，12，： | 1 |
| 20 | Contribution of sulfur-containing compounds to the colour-inhibiting effect and improved antioxidant activity of Maillard reaction products of soybean protein hydrolysates显示文摘 | Huang M G Liu P Song S Q | 2011 | J Sci Food Agric2011，91，： | 1 |
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