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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Vitamin D deficiency and hepatitis viruses-associated liver diseases:a literature review显示文摘The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses(HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide. Several studies have assessed the effects of vitamin D supplementation on the sustained virological response(SVR) to interferon(IFN) plus ribavirin(RBV) therapy in HBV and HCV infection. In these studies, inconsistent results were reported. This review addresses general aspects of vitamin D deficiency and, in particular, the significance of vitamin D hypovitaminosis in the outcome of HBVand HCV-related chronic liver diseases. Furthermore,current literature was reviewed in order to understand the effects of vitamin D supplementation in combination with IFN-based therapy on the virological response in HBV and HCV infected patients. | Nghiem Xuan Hoan Hoang Van Tong Le Huu Song Christian G Meyer Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，4： | 9 |
| 3 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 4 | Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes显示文摘 | Yang, JA Luan, XF Gui, HY Yan, P Yang, DF Song, XL Liu, W Hu, G Yah, BF | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 8 |
| 5 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 6 | Discovery of the first series of small molecule I-ISN1 entry inhibitors 显示文摘 | Song G P Yang S Zhang W | 2009 | J Med Chem2009，52，23： | 1 |
| 7 | A prototype clamp-on magneto-optical current transducer for power system metering and relaying显示文摘 | Song J Mclaren P G Thomson D J | 1995 | IEEE Transactions on Power Delivery1995，10，4： | 1 |
| 8 | Contribution of sulfur-containing compounds to the colour-inhibiting effect and improved antioxidant activity of Maillard reaction products of soybean protein hydrolysates显示文摘 | Huang M G Liu P Song S Q | 2011 | J Sci Food Agric2011，91，： | 1 |
| 9 | Synthesis, X-ray Crystallographic Analysis, and Antitumor Activity of N-( benzothiazole-2-yl ) -1-( fluorophenyl )-O, O-dialkyl-α-aminophospho - nares显示文摘 | JIN L H SONG B A ZHANG G P | 2006 | Bioorg Med Chem Lett2006，16，6： | 1 |
| 10 | Small interfering RNA targeting Fas protects mice against renalischemia-reperfusion injury显示文摘 | Hamar P Song E Kokeny G | 2004 | Proc Natl Acad Sci U S A2004，101，14： | 1 |
| 11 | The effect of rapid solidification on the microstructure and hydrogen storage properties of V35Ti25Cr40 hydrogen storage alloy 显示文摘 | PEI P SONG X P LIU J CHEN G L QIN X B WANG B Y | 2009 | Int J Hydrogen Energy2009，34，19： | 1 |
| 12 | OSMI/SYP61:A syntaxin protein in Arabidopsis controls abscisic acid-mediated and non-abscisic acid mediated responses to abiotic stress显示文摘 | Zhu J Gong Z Zhang C Song C P Damsz B Inan G Koiwa H Zhu J K Hasegawa P | | 0，，： | 1 |
| 13 | The homing of bone marrow MSCs to non-osseous sites for ectopic bone formation induced by osteoinduetive calcium phosphate显示文摘 | SONG G HABIBOVIC P BAO C | 2013 | Biomaterials2013，34，9： | 1 |
| 14 | Fermentation of soybean meal and its inclusion in diets for newly weaned pigs reduced diarrhea and measures of immunoreactivity in the plasma显示文摘 | Song Y S Pérez V G Pettigrew J E | 2010 | Animal Feed Science and Technology2010，159，1： | 1 |
| 15 | Influence of berm number on safety factor of tailings dam 显示文摘 | Song C W Yu G M Wang P S | 2011 | Advanced Materials Research2011，，： | 1 |
| 16 | An adaptive sliding mode backstepping control for the mobile manipulator with nonholonomic constraints 显示文摘 | CHEN N J SONG F Z LI G P | 2013 | Communications in Nonlinear Science and Numerical Simulation2013，18，10： | 1 |
| 17 | Alkoxysilane func- tionalized polycaprolartone/polysiloxane modified epoxy resin through sol-gel process显示文摘 | Liu P G Song J X He L H | 2008 | European Polymer Journal2008，44，3： | 1 |
| 18 | Rheological behavior of coal bio-oil slurries显示文摘 | FENG P HAG L F HUO C F WANG Z LIN W G SONG W L | 2014 | Energy2014，66，： | 1 |
| 19 | Chaotic improved PSO-based multiobjective optimization for minimization of power losses and L index in power systems显示文摘 | Chen G Liu L Song P | 2014 | Energy Conversion and Management2014，，86： | 1 |
| 20 | Determination of trapping pressure and temperature of petroleum inclusions using PVT simulation software: A case study of Lower Ordovician carbonates from the Lunnan low uplift, Tarim Basin显示文摘 | Liu D H Xiao X M Mi J K Li X Q Shen J G Song Z G Peng P A | 2003 | Mar Pet Geol2003，20，1： | 1 |
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