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您的检索式：作者名="SONG YingQing"
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| 1 | Inequalities for the Gaussian hypergeometric function显示文摘we study the monotonicity of certain combinations of the Gaussian hypergeometric functions F(-1/2,1/2;1;1- xc) and F(-1/2- δ,1/2 + δ;1;1- xd) on(0,1) for given 0 < c 5d/6 < ∞ andδ∈(-1/2,1/2),and find the largest value δ1 = δ1(c,d) such that inequality F(-1/2,1/2;1;1- xc) | SONG YingQing ZHOU PeiGui CHU YuMing | 2014 | Science China Mathematics2014，57，11： | 1 |
| 2 | Ramanujan's cubic transformation and generalized modular equation显示文摘We study the quotient of hypergeometric functionsμ_a~*(r)=π/2sin(πa) F(a,1-a;1;1-r^3)/F(a,1-a;1;r^3),r∈(0,1)in the theory of Ramanujan's generalized modular equation for a ∈(0,1/2],and find an infinite product formula for μ_(1/3)~*(r) by use of the properties of μ_a~*(r) and Ramanujan's cubic transformation.Besides,a new cubic transformation formula of hypergeometric function is given,which complements the Ramanujan's cubic transformation. | WANG MiaoKun CHU YuMing SONG YingQing | 2015 | Science China Mathematics2015，58，11： | 0 |
| 3 | Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells显示文摘SIRT6 belongs to the conserved NAD^(+)-dependent deacetylase superfamily and mediates multiple biological and pathological processes.Targeting SIRT6 by allosteric modulators represents a novel direction for therapeutics,which can overcome the selectivity problem caused by the structural similarity of orthosteric sites among deacetylases.Here,developing a reversed allosteric strategy Allo Reverse,we identified a cryptic allosteric site,Pocket Z,which was only induced by the bi-directional allosteric signal triggered upon orthosteric binding of NAD^(+).Based on Pocket Z,we discovered an SIRT6 allosteric inhibitor named JYQ-42.JYQ-42 selectively targets SIRT6 among other histone deacetylases and effectively inhibits SIRT6 deacetylation,with an IC50 of 2.33μmol/L.JYQ-42 significantly suppresses SIRT6-mediated cancer cell migration and pro-inflammatory cytokine production.JYQ-42,to our knowledge,is the most potent and selective allosteric SIRT6 inhibitor.This study provides a novel strategy for allosteric drug design and will help in the challenging development of therapeutic agents that can selectively bind SIRT6. | Qiufen Zhang Yingyi Chen Duan Ni Zhimin Huang Jiacheng Wei Li Feng Jun-Cheng Su Yingqing Wei Shaobo Ning Xiuyan Yang Mingzhu Zhao Yuran Qiu Kun Song Zhengtian Yu Jianrong Xu Xinyi Li Houwen Lin Shaoyong Lu Jian Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 0 |
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