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| 1 | Consequences of bullying victimization in childhood and adolescence:A systematic review and meta-analysis显示文摘AIM To identify health and psychosocial problems associated with bullying victimization and conduct a meta-analysis summarizing the causal evidence.METHODS A systematic review was conducted using Pub Med, EMBASE, ERIC and Psyc INFO electronic databases up to 28 February 2015. The study included published longitudinal and cross-sectional articles that examined health and psychosocial consequences of bullying victimization. All meta-analyses were based on qualityeffects models. Evidence for causality was assessed using Bradford Hill criteria and the grading system developed by the World Cancer Research Fund.RESULTS Out of 317 articles assessed for eligibility, 165 satisfied the predetermined inclusion criteria for meta-analysis.Statistically significant associations were observed between bullying victimization and a wide range of adverse health and psychosocial problems. The evidence was strongest for causal associations between bullying victimization and mental health problems such as depression, anxiety, poor general health and suicidal ideation and behaviours. Probable causal associations existed between bullying victimization and tobacco and illicit drug use. CONCLUSION Strong evidence exists for a causal relationship between bullying victimization, mental health problems and substance use. Evidence also exists for associations between bullying victimization and other adverse health and psychosocial problems, however, there is insufficient evidence to conclude causality. The strong evidence that bullying victimization is causative of mental illness highlights the need for schools to implement effective interventions to address bullying behaviours. | Sophie E Moore Rosana E Norman Shuichi Suetani Hannah J Thomas Peter D Sly James G Scott | 2017 | World Journal of Psychiatry2017，7，1： | 12 |
| 2 | Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds. | Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 3 | Ribavirin:Past,present and future显示文摘Before the advent of direct acting antiviral agents(DAAs) ribavirin, associated to pegylated-interferon played a crucial role in the treatment of chronic hepatitis C, preventing relapses and breakthroughs. In the present era of new potent DAAs, a place is still devoted to the drug. Ribavirin associated with sofosbuvir alone is efficient in the treatment of most cases of G2 infected patients. All options currently available for the last difficult-to-treat cirrhotic G3 patients contain ribavirin. Reducing treatment duration to 12 wk in G1 or G4 cirrhotic compensated patients is feasible thanks to ribavirin. Retreating patients with acquired anti NS5 A resistance-associated variants using ribavirin-based strategies could be useful. The addition of ribavirin with DAAs combinations however, leads to more frequent but mild adverse events especially in cirrhotic patients. Preliminary data with interferon-free second generation DAAs combinations without ribavirin suggest that future of the drug is jeopardized even in difficult-totreat patients: The optimization of ribavirin dosage according to an early monitoring of blood levels has been suggested to be relevant in double therapy with peginterferon or sofosbuvir but not with very potent combinations of more than two DAAs. | Véronique Loustaud-Ratti Marilyne Debette-Gratien Jérémie Jacques Sophie Alain Pierre Marquet DenisSautereau Annick Rousseau Paul Carrier | 2016 | World Journal of Hepatology2016，8，2： | 3 |
| 4 | HCV ‐associated B ‐cell non‐ H odgkin lymphomas and new direct antiviral agents显示文摘 | Paul Carrier Arnaud Jaccard Jérémie Jacques Tessa Tabouret Marilyne Debette‐Gratien Julie Abraham Laura Mesturoux Pierre Marquet Sophie Alain Denis Sautereau Marie Essig Véronique Loustaud‐Ratti | 2015 | Liver Int2015，，10： | 2 |
| 5 | Polymer nanocomposites: How to reach low flammability 显示文摘 | Serg B Sophie D Charaf J | 2006 | Macromolecular Symposia2006，233，1： | 1 |
| 6 | Metallophthalocyanine-Based Molecular Materials as Catalysts for Electrochemical Reactions显示文摘 | Zagal Jos6 H Griveau Sophie Francisco Silva J | 2010 | Coordination Chemistry Reviews2010，254，2324： | 1 |
| 7 | Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization显示文摘 | Lieben Liesbet Masuyama Ritsuko Torrekens Sophie Van Looveren Riet Schrooten Jan Baatsen Pieter Lafage-Proust Marie-Hélène Dresselaers Tom Feng Jian Q Bonewald Lynda F Meyer Mark B Pike J Wesley Bouillon Roger Carmeliet Geert | 2012 | EN2012，，5： | 1 |
| 8 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 9 | Intraocular concentration and pharmacokinetics of triamcinolone acetonide after a single intravitreal injection显示文摘 | Paul M Beer Sophie J Bakri Ravinder J Singh Weiguo Liu George B Peters Michael Miller | 2003 | Ophthalmology2003，，4： | 1 |
| 10 | Purification,Partial characterization and mode of action of enterococcin EFS2,an antilisterial bacteriocin produced by a swain of Enterococcusfaecalis isolation from a cheese显示文摘 | Sophie M P Emilia F Richard J | 1996 | International Journal of Food Microbiology1996，30，： | 1 |
| 11 | An analytical approach to the performance evaluation of master-slave computational model显示文摘 | Alain J M Sophie L B Zhen L | 1998 | Parallel Computing1998，24，56： | 1 |
| 12 | Intraocular concentration and pharmacokinetics of triamcinolone acetonide after a single intravitreal injection显示文摘 | Paul M Beer Sophie J Bakri Ravinder J Singh Weiguo Liu George B Peters Michael Miller | 2003 | Ophthalmology2003，，4： | 1 |
| 13 | Reversible color switchingand unusual solution polymerization of hydrazide-modifieddiacetylene lipids显示文摘 | Ulrich J Koonj S Sophie N | 1999 | Journal of the American Chemical Society1999，121，： | 1 |
| 14 | SJES14110700138146显示文摘 | Michael Manns Stanislas Pol Ira M Jacobson Patrick Marcellin Stuart C Gordon Cheng-Yuan Peng Ting-Tsung Chang Gregory T Everson Jeong Heo Guido Gerken Boris Yoffe William J Towner Marc Bourliere Sophie Metivier Chi-Jen Chu William Sievert Jean-Pierre Bron | 2014 | The Lancet2014，，9954： | 1 |
| 15 | In Women With Polycystic Ovary Syndrome and Obesity,Loss of Intra-abdominal Fat is Associated With Resumption of Ovulation显示文摘 | Walter KH Kuchenbecker Henk Groen Sophie J | 2011 | Human Reproduction2011，26，9： | 1 |
| 16 | A strategic framework for networked manufacturing显示文摘 | BENOIT M FRAYRET J M SOPHIE D A | 2000 | Computers in Industry2000，42，： | 1 |
| 17 | Early Prediction of Water-Holding Capacity in Meat by Multivariate Vibrational Spectroscopy 显示文摘 | DORTHE K P SOPHIE M HENRIK J A | 2003 | Meat Science2003，65，： | 1 |
| 18 | Purification, Partial characterization and mode of action of enterococcin EFS2,an antilisterial bacteriocin produced by a strain of of Enterococcus faecalis isolation from a cheese显示文摘 | Sophie M P Emilia F Richard J | 1996 | Int J Food Microbiol1996，30，6： | 1 |
| 19 | Role of vascular endothelial growth factor receptor 1 and vascular endothelial growth factor receptor 2 in the vasodilator response to vascular endothelial growth factor in the neonatal piglet lung显示文摘 | SOPHIE N JOHANNE B | 2005 | Cri Care Med2005，33，4： | 1 |
| 20 | Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells显示文摘 | Takayuki I Sophie S Chen X J | 2003 | International Journal of Oncology2003，23，1： | 1 |
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