|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Light-absorbing impurities on Keqikaer Glacier in western Tien Shan: concentrations and potential impact on albedo reduction显示文摘Light-absorbing impurities on glaciers are important factors that influence glacial surface albedo and accelerate glacier melt. In this study, the quantity of light-absorbing impurities on Keqikaer Glacier in western Tien Shan, Central Asia, was measured. We found that the average concentrations of black carbon was 2,180 ng/g, with a range from 250 ng/g to more than 10,000 ng/g. The average concentrations of organic carbon and mineral dust were 1,738 ng/g and 194 μg/g, respectively. Based on simulations performed with the Snow Ice Aerosol Radiative model simulations, black carbon and dust are responsible for approximately 64% and 9%, respectively, of the albedo reduction, and are associated with instantaneous radiative forcing of 323.18 W/m2(ranging from 142.16 to 619.25 W/m2) and 24.05 W/m2(ranging from 0.15 to69.77 W/m2), respectively. For different scenarios, the albedo and radiative forcing effect of black carbon is considerably greater than that of dust. The estimated radiative forcing at Keqikaer Glacier is higher than most similar values estimated by previous studies on the Tibetan Plateau, perhaps as a result of black carbon enrichment by melt scavenging. Light-absorbing impurities deposited on Keqikaer Glacier appear to mainly originate from central Asia, Siberia, western China(including the Taklimakan Desert) and parts of South Asia in summer, and from the Middle East and Central Asia in winter.A footprint analysis indicates that a large fraction(>60%) of the black carbon contributions on Keqikaer Glacier comes from anthropogenic sources. These results provide a scientific basis for regional mitigation efforts to reduce black carbon. | YuLan Zhang ShiChang Kang Min Xu Michael Sprenger TanGuang Gao ZhiYuan Cong ChaoLiu Li JunMing Guo ZhiQiang Xu Yang Li Gang Li XiaoFei Li YaJun Liu HaiDong Han | 2017 | Research in Cold and Arid Regions2017，9，2： | 4 |
| 2 | m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration显示文摘线粒体的功能无所不在地取决于表示并且在内部膜的进化保存 m-AAA 朊酶。这些 ATP 依赖的 peptidases 形式 hexameric 建筑群相应子单元积聚了。AFG3L2 子单元 homo-oligomeric isoenzymes 集合进或与 SPG7 (paraplegin ) 子单元进 hetero-oligomeric 解朊的建筑群。在 AFG3L2 的变化与 Purkinje 房间的损失描绘的主导的 spinocerebellar 混乱(SCA28 ) 被联系,而在 SPG7 的变化与 cortico 针的道的马达神经原引起世袭痉挛截瘫(HSP7 ) 的一种后退的形式主要被影响。多种的功能被分到 m-AAA 朊酶,它在线粒体充当质量控制和规章的酶。m-AAA 朊酶的损失影响 mitochondrial 蛋白质合成和呼吸并且在线粒体的 axonal 运输导致 mitochondrial 破碎和缺乏。而且 m-AAA 朊酶调整 mitochondrial 钙 uniporter (MCU ) 的集会复杂。在 AFG3L2 缺乏的线粒体的 MCU 子单元 EMRE 的损害降级为导致钙的房间死亡导致 deregulated MCU 建筑群,增加的 mitochondrial 钙举起和神经原的增加的危险的形成。进 Purkinje 房间的 cytosol 的钙流入的减小在一个 AFG3L2 缺乏的老鼠模型救混乱。在这评论,我们为 neurodegeneration 讨论在 m-AAA 朊酶和 mitochondrial 钙动态平衡和它的关联之间的关系并且描述在 Purkinje 房间明确地缺乏 MCU 的一个新奇老鼠模型。我们为在线粒体集成他们的多种的功能解释联系 neurodegenerative 混乱的致病的 m-AAA 朊酶上的一个新奇看法的结果誓言。 | Maria Patron, Hans-Georg Sprenger, Thomas Langer Maria Patron, Hans-Georg Sprenger, Thomas Langer | 2018 | Cell Research2018，28，3： | 3 |
| 3 | Protein tolerance to standard and high protein meals in patients with liver cirrhosis显示文摘AIM To investigate the plasma amino acid response and tolerance to normal or high protein meals in patients with cirrhosis.METHODS The plasma amino acid response to a 20 g mixed protein meal was compared in 8 biopsy-proven compensated cirrhotic patients and 6 healthy subjects.In addition the response to a high protein meal(1 g/kg body weight) was studied in 6 decompensated biopsy-proven cirrhotics in order to evaluate their protein tolerance and the likelihood of developing hepatic encephalopathy(HE) following a porto-caval shunt procedure.To test for covert HE,the 'number connection test'(NCT) was done on all patients,and an electroencephalogram was recorded in patients considered to be at Child-Pugh C stage.RESULTS The changes in plasma amino acids after a 20 g protein meal were similar in healthy subjects and in cirrhotics except for a significantly greater increase(P < 0.05) in isoleucine,leucine and tyrosine concentrations in the cirrhotics.The baseline branched chain amino acids/aromatic amino acids(BCAA/AAA) ratio was higher in the healthy persons and remained stable-but it decreased significantly after the meal in the cirrhotic group.After the high protein meal there was a marked increase in the levels of most amino acids,but only small changes occurred in the levels of taurine,citrulline,cysteine andhistidine.The BCAA/AAA ratio was significantly higher 180 and 240 min after the meal.Slightly elevated basal plasma ammonia levels showed no particular pattern.Overt HE was not observed in any patients.CONCLUSION Patients with stable liver disease tolerate natural mixed meals with a standard protein content.The response to a high protein meal in decompensated cirrhotics suggests accumulation of some amino acids but it did not precipitate HE.These results support current nutritional guidelines that recommend a protein intake of 1.2-1.5 g/kg body weight/day for patients with cirrhosis. | Octavio Campollo Dirk Sprengers Gitte Dam Hendrik Vilstrup Neil McIntyre | 2017 | World Journal of Hepatology2017，9，14： | 3 |
| 4 | Analysis of intrahepatic HBV-specific cytotoxic T-cells during and after acute HBV infection in humans显示文摘 | Dave Sprengers Renate G. van der Molen Johannes G. Kusters Robert A. De Man Hubert G.M. Niesters Solko W. Schalm Harry L.A. Janssen | 2006 | Journal of Hepatology2006，，2： | 2 |
| 5 | Stem cell therapy in PAD显示文摘 | Sprengers RW Moll FL Verhaar MC | 2010 | Eur J Vasc Endovasc Surg2010，39，1： | 1 |
| 6 | Ontogensis of embryonic porine ventral mesencephalon in the perspective of its potential use s xenograft in Parkinson's disease显示文摘 | Molenaar GJ Hogenesch RI Sprengers ME at al | 1997 | J Comp Neurol1997，382，1： | 1 |
| 7 | Longterm recurrent subarachnoid hemorrhage after adequate coiling versus clipping of ruptured intracranial aneurysms 显示文摘 | Schaafsma JD Sprengers ME van Rooij W J | 2009 | Strok2009，40，： | 1 |
| 8 | Comparison of melting in three and two dimensions:Microscopy of colloidal spheres显示文摘 | MURRAY C A SPRENGER W O WENK R A | 1990 | Phys Rev B1990，42，1： | 1 |
| 9 | Efficacy and safety of moxifloxacin vs clarithromycin for the treatment of community-acquired pneumonia (Abstract)显示文摘 | Hoffken G Meyeer HP Sprenger K | 1999 | J Antimicrob Chemother1999，44，： | 1 |
| 10 | On the formulation of geometrically nonlinear 3D-Rebar-elements using the enhanced assumed strain method显示文摘 | Sprenger W Wagner W | 1999 | Engineering structures1999，21，3： | 1 |
| 11 | Strength and deformation of steel fibre reinforced concrete at very low temperature显示文摘 | Rostasy F S Sprenger K H | 2000 | International Journal of Cement Composites and Light weight Concrete2000，53，： | 1 |
| 12 | Quality of life in pa- tients with no-option critical limb ischemia underlines the need for new effective treatment显示文摘 | Sprengers R W Teraa M Moll F L | 2010 | J Vasc Surg2010，52，4： | 1 |
| 13 | Analysis of intrahepatic HBV-specific cytotoxic T-cells during and after acute HBV infection in humans显示文摘 | Sprengers D van der Molen RG | 2006 | J Hepatol2006，45，2： | 1 |
| 14 | Insulin-like growth factor binding protein-rdated protein 1 (IGFBP-rPI) is a potential tumor suppressor protein for prostate cancer 显示文摘 | Sprenger C C Damon S E | 1999 | Cancer Res1999，59，10： | 1 |
| 15 | Enhanced release of cytokines,interleukin-2 receptors,and neopterin after long-distance running显示文摘 | Jacobs C | 1992 | Clinical Immunology and Immunopathology1992，53，： | 1 |
| 16 | Midterm clinical and magnetic resonance imaging follow-up of large and giant carotid artery aneurysms after therapeutic carotid artery occlusion显示文摘 | De Gast AN Sprengers ME van Rooij WJ | 2007 | Neurosurgery2007，60，6： | 1 |
| 17 | Early detection of renal damage caused by fumaric acid ester therapy by determination of urinary 32-mieroglobulin 显示文摘 | HRING N SPRENGER MHR H MINDLE M et 8-l | 2011 | British Journal of Dermatology2011，164，3： | 1 |
| 18 | Purification, cloning, and functional expression of sucrose : fructan 6-fruetosyltransferase, a key enzyme of fructan synthesis in barley 显示文摘 | SPRENGER S BORTLIK K BRANDT A | 1995 | Proceedings of the National Academy of Sciences USA1995，92，11： | 1 |
| 19 | Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo显示文摘 | Devi GR Sprenger CO Plymate SR | 2002 | Prostate2002，51，2： | 1 |
| 20 | 3D rotational angiography:The new gold standard in the detection of additional intracranial aneurysms显示文摘 | van Rooij WJ Sprengers ME de Gast AN | 2008 | AJNR Am J Neuroradiol2008，29，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员