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| 1 | Anti-microbial principles of selected remedial plants from Southern India显示文摘Objective:To examine the anti-bacterial activity of leaf extracts of Morus alba L.(Moraceae)and Piper betel L.(Piperaceae),and seed extracts of Bombax ceiba L.(Borabacaceae).Methods:We have partially purified plant extracts by solvent extraction method,and evaluated the effect of individual fractions on bacterial growth using Escherichia coli(E.coli),Pseudomonas aeruginosa(P.aeruginosa) and Staphylococcus aureus(S.aureus) bacterial strains.Results:Compared with Morus and Bombax fractions,Piper fractions showed significant growth inhibition on all the three types of bacteria studied.The EtOAc-hexane fractions of Piper leaves exhibited significant antibacterial activity with minimum inhibitory concentrations(MIC) of 50 μg/mL culture against both gram-positive and gram-negative bacteria.The EtOAc-fractions Ⅰ,Ⅱ,and Ⅳ inhibited bacterial colony formation on soft agar in addition to growth inhibition.A combination treatment of piper fractions with ampicillin resulted in significant growth inhibition in E.coli and P.aeruginosa,and combination with anticancer drug geldanamycin(2 μg/mL) showed selective growth inhibition against P.aeruginosa and S.aureus.Three major compounds,i.e.,eugenol,3-hexene-ol and stigmasterol,were primarily identified from Piper betel leaf extractions.Among the individual compounds,eugenol treatment showed improved growth inhibition compared with stigmasterol and 3-hexene-ol.Conclusions:We are reporting potential anti-bacterial compounds from Piper betel against both gram-positive and gram-negative bacteria either alone or in combination with drug treatment. | Tirupathi Rao G Suresh Babu K J Ujwal Kumar Sujana P A Veerabhadr Raoa Sreedhar AS | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 5 |
| 2 | Inhibition of Hsp90: a new strategy for inhibiting protein kinases显示文摘 | Sreedhar AS Soti C Csemrely P | 2004 | Biochim Biophys Acta2004，1697，12： | 1 |
| 3 | Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy - A comprehensive review 显示文摘 | Sreedhar AS Csermely P | 2004 | Pharmacol Ther2004，101，3： | 1 |
| 4 | Inhibition of Hsp90: a new strategy for inhibiting protein kinases 显示文摘 | Sreedhar AS Soti C Csermely P | 2004 | Biochim Biophys Acta2004，1697，： | 1 |
| 5 | lack of Heat Shock Response Triggers Programmed Cell death in a Rat Histiocytic Cell Line显示文摘 | Sreedhar AS Paedhasaradhi BV Begum Z | 1999 | FEBS Lett1999，456，2： | 1 |
| 6 | Molecular characteri- zation and expression analysis of hsp60 gene homologue of sheep blowfly, Lucilia cuprina显示文摘 | Kumar SM Janardban RP Sreedhar AS | 2015 | J Therm Biol2015，52，： | 1 |
| 7 | Heat shock proteins in the regulation of apoptosis:new strategies in tumor therapy:a comprehensive review显示文摘 | Sreedhar AS Csermely P | | 0，，03： | 1 |
| 8 | Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review显示文摘 | Sreedhar AS Csermely P | 2004 | Pharmacol Ther2004，101，3： | 1 |
| 9 | Inhibition of Hsp90:a new strategy for inhibiting protein kinases显示文摘 | Sreedhar AS Soti C Csermely P | 2004 | Biochim Biophys Acta2004，1697，12： | 1 |
| 10 | Hsp90 isoforms: Functions, expression and clinical importance 显示文摘 | Sreedhar AS Kalmar E Csermely P | 2004 | FEBS Lett2004，562，13： | 1 |
| 11 | A cross talk between cellular signaling and cellular redox state during heat - induced apoptosis in a rat histiocytoma显示文摘 | Sreedhar AS Pardhasaradhi BV Khar A | 2002 | Free Radical Biology and Medicine2002，32，3： | 1 |
| 12 | Agallochins J-L,new isopimarane diterpenoids from Excoecaria agallocha L显示文摘 | Rao VL Sreedhar K | 2003 | Nat Prod Res2003，17，： | 1 |
| 13 | Heat induced espression of CD95 and its correlation with activation of apoptosis upon heat shock in rat histiocytic tumor cells显示文摘 | Sreedhar AS Pardhasaradhi BV Khar A | 2000 | FEBS Lett2000，472，23： | 1 |
| 14 | HSIO0 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma 显示文摘 | Taiyab A Sreedhar AS Rao Ch M | 2009 | Biochem Pharmacol2009，78，2： | 1 |
| 15 | Hsp90 isoforms:functions, expression and clinical importance显示文摘 | Sreedhar AS Kalmar E Csermely P | 2004 | FEBS Lett2004，562，13： | 1 |
| 16 | Heat shock proteins in the regulation of apoptosis:new strategies in tumor therapy显示文摘 | Sreedhar AS Cserrnely P | 2004 | Pharmacol Ther2004，101，3： | 1 |
| 17 | Inhibition of Hsp90: a new strategy for inhibiting protein kinases 显示文摘 | SREEDHAR AS SOTI C CSERMELY P | 2004 | Biochim Biophys Acta2004，1697，12： | 1 |
| 18 | Heat shock proteins in the regulation of apoptosis:new strategies in tumor therapy a comprehensive review 显示文摘 | Sreedhar AS Csermely P | 2004 | Pharmacol Ther2004，101，3： | 1 |
| 19 | Hsp90 isoforms: functions, expression and clinical importance 显示文摘 | Sreedhar AS Kalmar E Gsermely P | 2004 | FEBS Lett2004，562，13： | 1 |
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