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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Improving RBF networks performance in regression tasks by means of a supervised fuzzy clustering显示文摘 | Staiano A Tagliaferri R Pedrycz W | 2006 | Neurocomputing2006，69，： | 1 |
| 3 | A practical guide for the diagnosis o{ primary Enteric nervous system disorders显示文摘 | Sch~ippi MG Staiano A Milla PJ | 2013 | J Pediatr Gastroenterol Nutr2013，57，5： | 1 |
| 4 | Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent path way显示文摘 | Hanif R Pattas A Feng Y Koutsos MI Qiao L Staiano Coico L | 1996 | Biochem Pharmacol1996，52，： | 1 |
| 5 | Fiber (Glucomannan) is beneficial in the treatment of childhood constipation 显示文摘 | Vera L B Erasmo M Staiano A | 2004 | Pediatrics2004，113，3： | 1 |
| 6 | Endothelin-B receptor mutation in patients with isolated Hirschsprung disease from a non-inbred population 显示文摘 | Auricchio A Casari G Staiano A | 1996 | Hum Mol G enet1996，5，3： | 1 |
| 7 | Competitive Versus Cooperative Exergame Play for African American Adolescentsj Executive Func- tion Skills: Short-Term Effects in a Long-Term Training Interven- tion 显示文摘 | Staiano A Abraham A Calvert S | 2012 | Developmental Psychology2012，，2： | 1 |
| 8 | Similarities in cycli vomiting syndrome across age group 显示文摘 | Prakash C Staiano A Rothbaum RJ | 2001 | Am J Gastroenterol2001，96，3： | 1 |
| 9 | Fiber(Glucomannan) is beneficial in the treatment of childhood comtipation显示文摘 | Vera LB Erasmo M Staiano A | 2004 | Pediatrics2004，113，3： | 1 |
| 10 | :Improving RBF Networks Performance in Regres-sionTasks by Means of a Supervised Fuzzy Clustering显示文摘 | STAIANO A TAGLIAFERRI R PEDRYCZ W | 2006 | Neurocomputing2006，，69： | 1 |
| 11 | Fiber (glucomannan) is beneficial in the treatment of childhood constipation显示文摘 | Loening-Baucke V Miele E Staiano A | 2004 | Pediatrics2004，113，31： | 1 |
| 12 | Improving RBF networks performance in regression tasks by means of a supervised fuzzy clustering 显示文摘 | Staiano A Tagliaferri R Pedrycz W | 2006 | Neurocomputing2006，69，1315： | 1 |
| 13 | Pediatric anorectal disorders 显示文摘 | Masi P Miele E Staiano A | 2008 | Gastro-enterol Clin North Am2008，37，3： | 1 |
| 14 | Pediatric anorectal disorders 显示文摘 | Masi P Mieli E Staiano A | 2008 | Gastroenterol Clin North Am2008，37，3： | 1 |
| 15 | BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCXl and NCX2:Possible relationship with mitochondrial membrane potential显示文摘 | Secondo A Staiano RI Scorziello A | 2007 | Cell Calcium2007，42，6： | 1 |
| 16 | Pediatric anorectal disorders 显示文摘 | Masi P Mieli E Staiano A | 2008 | Gastro-enterol Clin North Am2008，37，3： | 1 |
| 17 | Persistence of abnormal gastrointestinal motility after operation for Hirschsprung'sdisease显示文摘 | Tozzi A Staiano A | 2000 | Am J Gastroenterol2000，95，： | 1 |
| 18 | Improving RBF networks performance in regression tasks by means of a supervised fuzzy clustering显示文摘 | Staiano A Tagliaferri R Pedrycz W | 2006 | Neurocomputing2006，69，1315： | 1 |
| 19 | Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects 显示文摘 | Detoraki A Staiano RI Granata F | 2009 | J Allergy Clin Immunol2009，123，5： | 1 |
| 20 | Childhood functional gastrointestinal disorders: child/adolescent 显示文摘 | Rasquin A Di Lorenzo C Forbes D Guiraldes E Hyams JS Staiano A | 2006 | Gastroenterology2006，130，5： | 1 |
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