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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Cell-to-cell interactions in bone 显示文摘 | Stains J P Civitelli R | 2005 | Bioehem Biophys Res Commun2005，328，： | 1 |
| 3 | Characterization of a pollen-expressed gene encoding a putative pectin esterase of Petunia inflata显示文摘 | Mu J H Stains J P Kao T | 1994 | Plant Mol Siol1994，，3： | 1 |
| 4 | Beta-catenin and BM P-synergize to promote osteoblast differentiation and new hone formation 显示文摘 | MbMadele G Sheikh S Stains J P | 2005 | J Cell Biol Chem2005，94，2： | 1 |
| 5 | Early replication in pulmonary B cells after infection with Marek’s disease herpesvirus by the respiratory route 显示文摘 | Baaten B J Staines K A Smith L P | 2009 | Viral Immunol2009，22，6： | 1 |
| 6 | Characterization of a pollenexpressed gene encoding a putative pectin esterase of petunia inflate显示文摘 | MU J H STAINS J P KAO T | | Plant Mol Biol0，25，3： | 1 |
| 7 | Ensembl Genomes: an integrative resource for genome-scale data from non- vertebrate species显示文摘 | Kersey P J Staines D M Lawson D | 2012 | Nucleic Acids Research2012，40，1： | 1 |
| 8 | Beta-catenin and BMP2 synergize to promote osteoblast differentiation and new bone formation显示文摘 | Mbalaviele G Sheikh S Stains J P | 2005 | J Cell Biochem2005，94，2： | 1 |
| 9 | Heterogeneous nuclear ribonucleoprotein K represses transcription from a cytosine/thymidine-rich element in the osteocalcin promoter 显示文摘 | Stains J P Lecanda F Towler D A Civitelli R | 2005 | Biochem J2005，385，2： | 1 |
| 10 | Prognosis of cerebral vein and dural sinus thrombosis results of the international study cerebral vein and dural sinus thrombosis (ISCVT) 显示文摘 | Ferro J M Canhao P Stain J | 2004 | Stroke2004，35，3： | 1 |
| 11 | Cell to-cell interactions in bone 显示文摘 | STAINS J P CIVITELLI R | 2005 | Biochem Biophys Res Commun2005，328，3： | 1 |
| 12 | Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation显示文摘 | MBALAVIELE G SHEIKH S STAINS J P | 2005 | J Cell Biochem2005，94，2： | 1 |
| 13 | Gap junction in skeletal develop ment and function显示文摘 | STAINS J P CIVITELLI R | 2005 | BBA2005，1719，12： | 1 |
| 14 | Beta-catenin and BMP- 2 synergize to promote osteoblast differentiation and new bone forma- tion显示文摘 | Mbalaviele G Sheikh S Stains J P | 2005 | J Cell Biochem2005，94，2： | 1 |
| 15 | Gap junctional regulation of signal transduction in bone cells显示文摘 | Buo A M Stains J P | 2014 | FEBS Lett2014，588，8： | 1 |
| 16 | Information obtained by liver biopsy in 100 tuberculous patients显示文摘 | Morere P Nouvet G Stain J P | 1975 | Sem Hop1975，51，3134： | 1 |
| 17 | Gap junctions regulate extracellular signal- regulated kinase signaling to affect gene transcription 显示文摘 | Stains J P Civitelli R | 2005 | Mol Biol Cell2005，16，： | 1 |
| 18 | On dry friction modelling and simulation in kinematically excited oscillatory systems 显示文摘 | Stain G J Zahoransky R Mucka P | 2008 | Journal of Sound and Vibration2008，311，： | 1 |
| 19 | Heart rate variability:measurement and clinical utility显示文摘 | KLEIGER R E STAIN P K BIGGER J T J R | 2005 | Ann Noninvasive Etectrocardiogr2005，10，1： | 1 |
| 20 | Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation显示文摘 | Mbalaviele G Sheikh S Stains J P | 2005 | J Cell Biochem2005，94，2： | 1 |
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