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| 1 | Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure显示文摘Acute hepatic failure due to hepatitis B virus(HBV)can occur both during primary infection as well as after reactivation of chronic infection.Guidelines recommend considering antiviral therapy in both situations,although evidence supporting this recommendation is weak.Since HBV is not directly cytopathic,the mechanism leading to fulminant hepatitis B is thought to be primarily immunemediated.Therefore,immunosuppression combined with antiviral therapy might be a preferred therapeutic intervention in acute liver failure in hepatitis B.Here wereport our favourable experience in three hepatitis B patients with fulminant hepatic failure who were treated by combining high-dose steroid therapy with standard antiviral treatment,which resulted in a rapid improvement of clinical and liver parameters. | Jan-Hendrik Bockmann Maura Dandri Stefan Lüth Nadine Pannicke Ansgar W Lohse | 2015 | World Journal of Gastroenterology2015，21，7： | 13 |
| 2 | IRG1 induced by heme oxygenase- 1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production显示文摘 | Md Jamal Uddin Yeonsoo Joe Seul-Ki Kim Sun Oh Jeong Stefan W Ryter Hyun-Ock Pae Hun Taeg Chung | 2016 | Cellular & Molecular Immunology2016，13，2： | 10 |
| 3 | 酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。 | 陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB | 2021 | 中华高血压杂志2021，29，2： | 9 |
| 4 | Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender显示文摘AIM: To investigate age-and gender-related differences in non-culprit versus culprit coronary vessels assessed with virtual histology intravascular ultrasound (VH-IVUS). METHODS: In 390 patients referred for coronary angiography to a single center (Luzerner Kantonsspital, Switzerland) between May 2007 and January 2011, 691 proximal vessel segments in left anterior descending, circumflex and/or right coronary arteries were imaged by VH-IVUS. Plaque burden and plaque composition(fibrous, fibro-fatty, necrotic core and dense calcium volumes) were analyzed in 3 age tertiles, according to gender and separated for vessels containing non-culprit or culprit lesions. To classify as vessel containing a culprit lesion, the patient had to present with an acute coronary syndrome, and the VH-IVUS had to be performed in a vessel segment containing the culprit lesion according to conventional coronary angiography. RESULTS: In non-culprit vessels the plaque burden increased significantly with aging (in men from 37% ± 12% in the lowest to 46% ± 10% in the highest age tertile, P < 0.001; in women from 30% ± 9% to 40% ± 11%, P < 0.001); men had higher plaque burden than women at any age (P < 0.001 for each of the 3 age tertiles). In culprit vessels of the lowest age tertile, plaque burden was significantly higher than that in non- culprit vessels (in men 48% ± 6%, P < 0.001 as compared to non-culprit vessels; in women 44% ± 18%, P = 0.004 as compared to non-culprit vessels). Plaque burden of culprit vessels did not significantly change during aging (plaque burden in men of the highest age tertile 51% ± 9%, P = 0.523 as compared to lowest age tertile; in women of the highest age tertile 49% ± 8%, P = 0.449 as compared to lowest age tertile). In men, plaque morphology of culprit vessels became increasingly rupture-prone during aging (increasing percentages of necrotic core and dense calcium), whereas plaque morphology in non-culprit vessels was less rupture-prone and remained constant during aging. In women, necrotic core in non-culprit vessels was very low at young age, but increased during aging resulting in a plaque morphology that was very similar to men. Plaque morphology in culprit vessels of young women and men was similar. CONCLUSION: This study provides evidence that age-and gender-related differences in plaque burden and plaque composition significantly depend on whether the vessel contained a non-culprit or culprit lesion. | Andreas W Schoenenberger Nadja Urbanek Stefan Toggweiler Andreas E Stuck Thérèse J Resink Paul Erne | 2013 | World Journal of Cardiology2013，5，3： | 7 |
| 5 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 6 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | The Lancet . 2005 (9454)2005，，： | 2 |
| 7 | 22-gauge core vs 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses显示文摘AIM To compare the aspiration needle(AN) and core biopsy needle(PC) in endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) of abdominal masses.METHODS Consecutive patients referred for EUS-FNA were included in this prospective single-center trial. Each patient underwent a puncture of the lesion with both standard 22-gauge(G) AN(Echo Tip Ultra; Cook Medical, Bloomington, Indiana, United States) and the novel 22 G PC(Echo Tip Pro Core; Cook Medical, Bloomington, Indiana, United States) in a randomized fashion; histology was attempted in the PC group only. The main study endpoint was the overall diagnostic accuracy, including the contribution of histology to the final diagnosis. Secondary outcome measures included material adequacy, number of needle passes, and complications.RESULTS Fifty six consecutive patients(29 men; mean age 68 years) with pancreatic lesions(n = 38), lymphadenopathy(n = 13), submucosal tumors(n = 4), or others lesions(n = 1) underwent EUS-FNA using both of the needles in a randomized order. AN and PC reached similar overall results for diagnostic accuracy(AN: 88.9 vs PC: 96.1, P = 0.25), specimen adequacy(AN: 96.4% vs PC: 91.1%, P = 0.38), mean number of passes(AN: 1.5 vs PC: 1.7, P = 0.14), mean cellularity score(AN: 1.7 vs PC: 1.1, P = 0.058), and complications(none). A diagnosis on the basis of histology was achieved in the PC group in 36(64.3%) patients, and in 2 of those as the sole modality. In patients with available histology the mean cellularity score was higher for AN(AN: 1.7 vs PC: 1.0, P = 0.034); no other differences were of statistical significance.CONCLUSION Both needles achieved high overall diagnostic yields and similar performance characteristics for cytological diagnosis; histological analysis was only possible in 2/3 of cases with the new needle. | William Sterlacci Athanasios D Sioulas Lothar Veits Pervin G?nüllü Guido Schachschal Stefan Groth Mario Anders Christos K Kontos Theodoros Topalidis Andrea Hinsch Michael Vieth Thomas R?sch Ulrike W Denzer | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 8 | Semiautomated 3D Root Segmentation and Evaluation Based on X-Ray CT Imagery显示文摘Background.Computed X-ray tomography(CTX)is a high-end nondestructive approach for the visual assessment of root architecture in soil.Nevertheless,in order to evaluate high-resolution CTX data of root architectures,manual segmentation of the depicted root systems from large-scale volume data is currently necessary,which is both time consuming and error prone.The duration of such a segmentation is of importance,especially for time-resolved growth analysis,where several instances of a plant need to be segmented and evaluated.Specifically,in our application,the contrast between soil and root data varies due to different growth stages and watering situations at the time of scanning.Additionally,the root system itself is expanding in length and in the diameter of individual roots.Objective.For semiautomated and robust root system segmentation from CTX data,we propose the RootForce approach,which is an extension of Frangi’s“multi-scale vesselness”method and integrates a 3D local variance.It allows a precise delineation of roots with diameters down to severalμm in pots with varying diameters.Additionally,RootForce is not limited to the segmentation of small below-ground organs,but is also able to handle storage roots with a diameter larger than 40 voxels.Results.Using CTX volume data of full-grown bean plants as well as time-resolved(3D+time)growth studies of cassava plants,RootForce produces similar(and much faster)results compared to manual segmentation of the regarded root architectures.Furthermore,RootForce enables the user to obtain traits not possible to be calculated before,such as total root volume(Vroot),total root length(Lroot),root volume over depth,root growth angles(θmin,θmean,andθmax),root surrounding soil density Dsoil,or form fraction F.Discussion.The proposed RootForce tool can provide a higher efficiency for the semiautomatic high-throughput assessment of the root architectures of different types of plants from large-scale CTX.Furthermore,for all datasets within a growth experiment,only a single set of parameters is needed.Thus,the proposed tool can be used for a wide range of growth experiments in the field of plant phenotyping. | Stefan Gerth Joelle Claußen Anja Eggert Norbert Wörlein Michael Waininger Thomas Wittenberg Norman Uhlmann | 2021 | Plant Phenomics2021，3，1： | 2 |
| 9 | Magnetic response of metamaterialst 100 terahertz显示文摘 | Stefan Linden L Christian E Martin W | 2004 | Science2004，306，5700： | 1 |
| 10 | Investigation of aortocoronary artery bypass grafts by muhislice spiral computed tomography with electrocardiographic, gated image reconstruction显示文摘 | Dieter R Stefan U Evelyn W | 2001 | Am J Cardiol2001，88，7： | 1 |
| 11 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | 2005 (9454)2005，，9454： | 1 |
| 12 | SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information 显示文摘 | Marco B Stefan B Andrew W | 2014 | Nucleic Acids Res2014，42，1： | 1 |
| 13 | Magnetic resonance arthrography of the hip in femoroacetabular impingement : Technique and findings 显示文摘 | Stefan W Michael L Reinhold G | 2005 | Oper Tech Orthop2005，15，： | 1 |
| 14 | Time-dependent attenuator for dynamic range reduction of lidar signals显示文摘 | STEFAN L VOLKER W JENS B | 1997 | Appl Opt1997，36，15： | 1 |
| 15 | Abundance and phylogenetic affiliation of iron reducers in activated sludge as as sessed by fluorescence in situ hybridization and microautora diography 显示文摘 | Jeppe L N Stefan J Michael W | 2002 | Appl Environ Microbiol2002，68，9： | 1 |
| 16 | Development of an enzymelinked immunosorbent assay for azadirachtins显示文摘 | STEFAN S INGRID W | 1997 | J Agric Food Chem1997，45，： | 1 |
| 17 | Treatment of colon and lung cancer patients with ex vivo heat shock protein 70 peptide-activa- ted autologous natural killer cells~ a clinical phase I trial显示文摘 | Stefan S Krause W Robert G | 2004 | Clin Cancer Res2004，10，1： | 1 |
| 18 | Investigation of aortocoronary artery by- pass graft by multislice spiral computed tomography with electrocadiographic, gated image reconstruction显示文摘 | Dieter R Stefan U Evelan W | 2001 | Am J Cardiol2001，88，7： | 1 |
| 19 | Investigation of aortocoronary artery bypass grafts by multislice spiral computed tomograhphy with electrocardiographic,gated image reconstruction显示文摘 | Dieter R Stefan U Evelyn W | 2001 | Am J Cardiol2001，88，7： | 1 |
| 20 | Development of an IL-6 inhibitor based on the functional analysis of routine IL-6 Ra显示文摘 | Miesinger M Y Serge H Stefan W | 2009 | Chem and Biol2009，16，7： | 1 |
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