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| 1 | Does needle calibre affect pain and complication rates in patients undergoing transperineal prostate biopsy? A prospective, randomized trial显示文摘Transperineal 前列腺活体检视是能被用来从前列腺获得组织学的样品的一个过程。两个都改进活体检视核心样品和前列腺癌症察觉的质量,我们当前正在执行比较用 18 G 针获得到用 16 G 针获得的那些的前列腺活体检视样品的未来的、使随机化的试用。这初步的研究的目的是在两个组评估疼痛和复杂并发症率以便估计与一根更大的口径针执行前列腺活体检视是否是一个可行过程。经历 transperineal 前列腺活体检视的 187 个病人有希望地被评估并且把组划分了成二。第一个组(94 个病人,组织 A ) 用 16 G 针和第二个组收到了 transperineal 前列腺活体检视(93 个病人,组织 B ) 与 18 G 针经历了 transperineal 前列腺活体检视。麻醉在所有题目在 prostatic 顶与单个会阴的注射被获得。视觉类似物规模(管) 和面部表情规模(FES ) 被用来在每个组在过程的多重步期间估计疼痛。因为它能潜在地影响病人们经历了的疼痛和复杂并发症,一张详细问询表被用来关于药使用获得信息。在过程以后的二个星期,早、迟了的复杂并发症被评估。统计分析用非参量的测试被执行。前列腺特定的抗原(PSA ) 和药使用在在二个组之间的基线是类似的。疼痛没在 18- 和 16 个 G 针组之间显著地在前列腺活体检视,与 VAS 和 FES 仪器一起被测量,期间不同,并且没有重要差别处于在这些组之间的早或迟了的复杂并发症率被发现。有 16 G 针的 Transperineal 前列腺活体检视以疼痛和复杂并发症率是一个可行过程。有更大的耐心的人口的进一步的研究被要求估计这个过程是否能改进前列腺癌症察觉率。 | Saredi Giovanni Maria Chiara Sighinolfi Fidanza Francesco De Stefani Stefano Micali Salvatore Maurizio Paterlini Roberto D'Amico Bianchi Giampaolo | 2009 | Asian Journal of Andrology2009，11，6： | 6 |
| 2 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Natural course of functional dyspepsia after Helicobacter pylori eradication:a seven-year survey显示文摘 | Di Mario F Stefani N BòN D | 2005 | Dig Dis Sci2005，50，12： | 1 |
| 5 | Angiotensin Ⅱ induces apoptosis of human endothelial 显示文摘 | Stefanie D Volker R Ulrike W | 1997 | Cells Circulation Research1997，81，： | 1 |
| 6 | VDAC1 selectively trans-fers apoptotic Ca2+ signals to mitochondria 显示文摘 | De Stefani D Bononi A Romagnoli A | 2012 | Cell Death Differ2012，19，2： | 1 |
| 7 | Metabolic flux analysis in mammalian cell culture 显示文摘 | Lake E Q Stefanie D Jens 0 K | 2010 | Metab Eng2010，12，： | 1 |
| 8 | The microRNA-17-92 cluster:still a miRacle?显示文摘 | Angelika B Stefanie D | 2009 | Cell Cycle2009，8，23： | 1 |
| 9 | Use of NIT (near infrared transmission) spectroscopy for semolina analysis显示文摘 | STEFANIS E D SGRULLETTA D | 1996 | Tecnica-Molitoria1996，47，9： | 1 |
| 10 | The let-7microRNA represses cell prolif-eration pathways in human cells显示文摘 | Johnson CD Esquela-Kerscher A Stefani G Byrom M Kelnar K Ovcharenko D | 2007 | Cancer Res2007，67，16： | 1 |
| 11 | Use of NIT(near infrared transmission) spectroscopy for semolina analysis显示文摘 | de Stefanis E Sgrullelta D | 1996 | Tecnicamolitoria1996，47，9： | 1 |
| 12 | DTC drives for wide speed range applications using a robust flux-weakening algorithm 显示文摘 | CASADEI D SERRA G STEFANI A | 2007 | IEEE Trans on Industrial Electronics2007，54，5： | 1 |
| 13 | Primary breast lymphoma显示文摘 | Vianello F Sgarabotto D Stefani PM | 1998 | Forum Genova1998，8，2： | 1 |
| 14 | Noise component in muzzle voltage traces显示文摘 | Melton D Stefani F | 2005 | IEEE Transactions on Magnetics2005，41，1： | 1 |
| 15 | Structural and functiona link between the mitochondrial network and the endoplasmic reticulum显示文摘 | Giorgi C De Stefani D Bononi A | 2009 | Int J Biochem Cell Biol2009，41，10： | 1 |
| 16 | Linezolid resistance in staphylococci 显示文摘 | Stefani S Bongiomo D Mongelli G | 2010 | Pharmaceuticals2010，3，7： | 1 |
| 17 | Tryptophan N-glucoside in fruits and fruit juices显示文摘 | Stefanie D Jochen B Markus H | | 0，，10： | 1 |
| 18 | Use of NIT (near infrared transmission) spectroscopy for semolina analysis显示文摘 | Stefanis E De Sgrulletta D | 1996 | Tecnicamolitoria1996，47，9： | 1 |
| 19 | In vitro and in vivo conditional sensitization of hepatoeellular carcinoma cells to TNF- induced apoptosis by Taxol 显示文摘 | Minem VG De Stefanis D Costelli P | 2015 | Cell Cycle2015，14，7： | 1 |
| 20 | Opioids decrease high-voltage activated calcium currents in acutely dissociated neostriatal neurons 显示文摘 | Stefani A Surmeier D J Bernardi G | 1994 | Brain Res1994，642，12： | 1 |
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