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| 1 | The role of leptin/adiponectin ratio in metabolic syndrome and diabetes显示文摘 | Patricio López-Jaramillo Diego Gómez-Arbeláez Jose López-López Cristina López-López Javier Martínez-Ortega Andrea Gómez-Rodríguez Stefany Triana-Cubillos | 2014 | Hormone Molecular Biology and Clinical Investigation2014，，1： | 4 |
| 2 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 3 | Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress 显示文摘 | Park DS Morris E J Stefanis L | 1998 | J Neurosci1998，18，3： | 1 |
| 4 | The contrasting role of ICE family proteases and interleukin-lB in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxidedismutas down- regulation显示文摘 | Troy CM Stefanis L Prochantz A | 1996 | Proc Natl Acad Sci USA1996，93，： | 1 |
| 5 | A diverse family of phenylalanine ammonia lyase genes expressed in pine 显示文摘 | Butland Stefanie L Chow L Monical Ellis B E | 1998 | Plant Molecular Biology1998，37，： | 1 |
| 6 | Caspase-dependent and -independent neuronal death: two distinct pathways to neuronal injury显示文摘 | Stefanis L | 2005 | Neuroscientist2005，11，1： | 1 |
| 7 | The effectiveness of trastuzumab (Herceptin) combined with chemotherapy for gastric carcinoma with overexpression of the c-erbB-2 protein显示文摘 | Rebischung C Barnoud R Stefani L | 2005 | Gastric Cancer2005，8，4： | 1 |
| 8 | Caspase inhibition: a potential therapeutic strategy in neurological diseases显示文摘 | Rideout HJ Stefanis L | 2001 | Histol Histopathol2001，16，3： | 1 |
| 9 | Alpha-synuclein and protein degradation systems:a reciprocal relationship显示文摘 | Xilouri M Brekk O R Stefanis L | 2013 | Mol Neurobiol2013，47，2： | 1 |
| 10 | Impaired degradation of mutant alpha-synuclein by chaperonemediated autophagy显示文摘 | Cuervo AM Stefanis L Fredenburg R | | 0，，5688： | 1 |
| 11 | A diverse family of phenylalanine ammonia-lyase genes expressed in pine trees and cell cultures显示文摘 | Stefanie L B Monica L C Brian E E | 1998 | Plant Molecular Biology1998，37，1： | 1 |
| 12 | The effectiveness of trastuzumab (Herceptin) combined with chemotherapy for gastric carcinoma with overexpression of the c-erbB-2 protein 显示文摘 | Rebisc hung C Barnoud R Stefani L | 2005 | Gastric Cancer2005，8，4： | 1 |
| 13 | Acute effects of physiological increments of brain natriuretic peptede in humans显示文摘 | Stefani L Lazzeri C | 1995 | Hypertension1995，26，： | 1 |
| 14 | Impaired degradation of mutant a-synuclein bychaperone-mediated autophagy显示文摘 | Cuervo AM Stefanis L Fredenburg R | 2004 | Science2004，305，5688： | 1 |
| 15 | Caspase-dependent and Independent Death of Camptothecin-treated Embryonic Cortical Neurons显示文摘 | STEFANIS L PARK DS FRIEDMAN WJ | 1999 | J Neurosci(SO020-7454)1999，19，15： | 1 |
| 16 | The effective- ness of trastuzumab (Herceptin) combined with chemotherapy for gastric carcinoma with overexpression of the C-erbB-2 protein 显示文摘 | Rebischung C Barnoud R Stefani L | 2005 | Gastric Cancer2005，8，4： | 1 |
| 17 | Complexex of copper (Ⅰ) with triphenylphosphine 显示文摘 | Costa G Reisenhofer E Stefani L | 1965 | J Inorg Nucl Chem1965，27，： | 1 |
| 18 | Inherent toxicity of aggregates implies a co mmon mechanism for protein misfolding diseases显示文摘 | Bucciantini M Giannoni E Chiti F Baroni F Formigli L Zurdo J Taddei N Ramponi G Dobson C M Stefani M | 2002 | Nature2002，416，： | 1 |
| 19 | Peer, self and tutor assessment: Relative reliabilities显示文摘 | Stefani L A J | 1994 | Studies in Higher Education1994，19，1： | 1 |
| 20 | Cloning and expression of a cDNA coding for the anticoagulant hirudin from the bloodsucking leech Hirudo medicinalis显示文摘 | Degryse E Stefani L, | 1986 | Proc Natl Acad Sci USA1986，83，： | 1 |
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