|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 比较3.0T膝关节成像中各向同性三维快速自旋回波成像与标准二维成像的影像质量及诊断价值显示文摘本研究的目的是比较新开发的脂肪抑制中间加权(IM-w)3D快速自旋回波(FSE)序列与标准2D IM-w FSE序列评价膝关节异常表现的影像质量及诊断价值。50例病人行3.0TMRI检查。影像由3名放射科医师独立评估。2DFSE序列的影像质量评定明显高于3D(P〈0.05)。3D序列对软骨病变的敏感度略高。但特异度较低。2D序列显示低对比的结构效果较好,而高对比的结构在3D序列显示更好。2D序列的可信度评分高于3D序列,但差异无统计学意义。 | O. Ristow L. Steinbach G. Sabo R. Krug M. Huber I. Rauscher 刘艳杰(译) 李威(校) | 2009 | 国际医学放射学杂志2009，32，4： | 8 |
| 2 | Inhibition of epidermal growth factor receptor signaling protects human malignant glioma cells from hypoxia - induced cell death显示文摘Epidermal growth factor receptor(EGFR)signaling has become an importanttarget for drug development becauseEGFR signaling enhances tumor cell proliferation,migration,and invasion and inhibits apoptosis.However,theresults of clinical trials using EGFR inhibitors in patients with solid tumors have been disappointing.Here,wereport a protective effect of the EGFR inhibitors AG1478 and PD153035 against cell death induced by acute hy-poxia,which contrasts with their proapoptotic effects under normoxia.Under hypoxic conditions,both agents re- | Steinbach JP Klumpp A Wolburg H Weller M | 2004 | 中国神经肿瘤杂志2004，2，1： | 4 |
| 3 | Development of ^(18)F-labeled radiotracers for neuroreceptor imaging with positron emission tomography显示文摘Positron emission tomography(PET)is an in vivo molecular imaging tool which is widely used in nuclear medicine for early diagnosis and treatment follow-up of many brain diseases.PET uses biomolecules as probes which are labeled with radionuclides of short half-lives,synthesized prior to the imaging studies.These probes are called radiotracers.Fluorine-18 is a radionuclide routinely used in the radiolabeling of neuroreceptor ligands for PET because of its favorable half-life of 109.8 min.The delivery of such radiotracers into the brain provides images of transport,metabolic,and neurotransmission processes on the molecular level.After a short introduction into the principles of PET,this review mainly focuses on the strategy of radiotracer development bridging from basic science to biomedical application.Successful radiotracer design as described here provides molecular probes which not only are useful for imaging of human brain diseases,but also allow molecular neuroreceptor imaging studies in various small-animal models of disease,including geneticallyengineered animals.Furthermore,they provide a powerful tool for in vivo pharmacology during the process of pre-clinical drug development to identify new drug targets,to investigate pathophysiology,to discover potential drug candidates,and to evaluate the pharmacokinetics and pharmacodynamics of drugs in vivo. | Peter Brust Jrg van den Hoff Jrg Steinbach | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 4 | Modeling Human Blockers in Millimeter Wave Radio Links显示文摘In this paper, we investigate the loss caused by multiple humans blocking millimeter wave frequencies. We model human blockers as absorbing screens of infinite height with two knife-edges. We take a physical optics approach to computing the diffraction around the absorbing screens. This approach differs to the geometric optics approach described in much of the literature. The blocking model is validated by measuring the gain from multiple-human blocking configurations on an indoor link. The blocking gains predicted using Piazzi's numerical integration method (a physical optics method) agree well with measurements taken from approximately 2.7 dB to -50 dB. Thereofre, this model is suitable for real human blockers. The mean prediction error for the method is approximately -1.2 dB, and the standard deviation is approximately 5 dB. | Jonathan S. Lu Daniel Steinbach Patrick Cabrol Philip Pietraski | 2012 | ZTE Communications2012，10，4： | 3 |
| 5 | Partial anterior cruciate ligament tears treated with intraligamentary plasma rich in growth factors显示文摘AIM:To evaluate the effect of the application of plasma rich in growth factors(PRGF)-Endoret to the remaining intact bundle in partial anterior cruciate ligament(ACL)tears.METHODS:A retrospective review of the rate of return to play in football players treated with the application of PRGF-Endoret in the remaining intact bundle in partial ACL injuries that underwent surgery for knee instability.Patients with knee instability requiring revision surgery for remnant ACL were selected.PRGF was applied in the wider part of posterolateral bundle and the time it took patients to return to their full sporting activities at the same level before the injury was evaluated.RESULTS:A total of 19 patients were reviewed.Three had a Tegner activity level of 10 and the remaining 16level 9.The time between the injury and the time of surgery was 5.78 wk(SD 1.57).In total,81.75%(16/19)returned to the same pre-injury level of sport activity(Tegner 9-10).17 males and 2 females were treated.The rate of associated injury was 68.42%meniscal lesions and 26.31%cartilage lesions.The KT-1000 values were normalized in all operated cases.One patient was not able to return to sport due to the extent of their cartilage lesions.The 15 patients with Tegner activity level 9 returned to play at an average of 16.20 wk(SD1.44)while the 3 patients with Tegner activity level 10did so in 12.33 wk(SD 1.11).CONCLUSION:With one remaining intact bundle the application of PRGF-Endoret in instability cases due to partial ACL tear showed high return to sport rates at pre-injury level in professional football players. | Roberto Seijas Oscar Ares Xavier Cuscó Pedro lvarez Gilbert Steinbacher Ramón Cugat | 2014 | World Journal of Orthopedics2014，5，3： | 3 |
| 6 | Microstructure analyses and phase-field simulation of partially divorced eutectic solidification in hypoeutectic Mg-Al Alloys显示文摘In this study the partially divorced eutectic microstructure ofα-Mg andβ-Mg17Al12was investigated by electron backscatter diffraction,transmission electron microscopy,and phase-field modeling in hypoeutectic Mg-Al alloys.The orientation relationships between the individual eutecticαgrains,eutecticβphase,and primaryαgrains were investigated.While the amount of eutectic morphology is primarily determined by the Al content,the in-depth microstructure analyses and the phase-field simulation suggest non-interactive nucleation and growth of eutecticαphase in theβphase grown on the interdendritic primaryαdendrites.Also,phase-field simulations showed a preferred nucleation sequence where theβphase nucleates first and subsequently triggers the nucleation of eutecticαphase at the movingβphase solidification front,which supports the microstructural analysis results. | Joo-Hee Kang Jiwon Park Kyung Song Chang-Seok Oh Oleg Shchyglo Ingo Steinbach | 2022 | Journal of Magnesium and Alloys2022，10，6： | 2 |
| 7 | Novel ^(99m)Tc labeled σ r eceptor ligand as a potential tumorimaging agent显示文摘A novel 99mTc labeled complex, [N-[2-((2-oxo-2-(4-(3-phenylpropyl)piperazin-1-yl)ethyl) (2-mercaptoethyl)amino)acetyl]-2-aminoethanethiolato]Technetium(V) oxide (PPPE-MAMA′-99mTcO) ([99mTc]-2) has been designed and prepared based on the integrated approach. The corresponding rhenium complex (PPPE-MAMA′-ReO)(Re-2) has been prepared and characterized. In vitro competi-tion binding assays show moderate affinity of Re-2 towards σ1 and σ2 receptors with Ki values of 8.67 ± 0.07 and 5.71 ± 1.88 μmol, respectively. Planar images obtained at 0.5 h, 4 h, 20 h after i.v. in-jection indicate the accumulation of [99mTc]-2 in MCF-7 human breast tumor bearing mice at 20 h. Furthermore, the accumulation of [99mTc]-2 has been inhibited at 20 h after co-injection of [99mTc]-2 plus haloperidol (1 mg/kg). Biodistribution studies of [99mTc]-2 display an in vivo tumor uptake of 0.14% ± 0.01% ID/g at 24 h post i.v. injection with a tumor/muscle ratio of 6.02 ± 0.87. The above results suggest that [99mTc]-2, derived from a previously published lead compound, retains certain tumor uptake and affinity for σ receptors. [99mTc]-2 may be used as a basis for further structural modifications to develop tumor imaging agents with high affinity for σ receptors. | FAN Caiyun1, JIA Hongmei1, Deuther-Conrad Winnie2, Brust Peter2, Steinbach J?rg2 & LIU Boli1 1. Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, Department of Chemistry, Beijing Normal University, Beijing 100875, China 2. Institute of Interdisciplinary Isotope Research, Permoserstr. 15, 04318 Leipzig, Germany Correspondence should be addressed to Liu Boli | 2006 | Science China Chemistry2006，49，2： | 2 |
| 8 | 查看详情显示文摘 | K B MacAdam A Steinbach C Wieman | | 0，，： | 2 |
| 9 | Specificity of cardiac troponins Ⅰ and T in renal disease显示文摘 | Willging S Keller F Steinbach G | 1998 | Clin Chem Lab Med1998，36，： | 1 |
| 10 | Differential inhibition of renal cancer cell invasion mediated by fibronectin ,collagen IV and laminin显示文摘 | Gross S Steinbach F | 2000 | Cancer Lett2000，155，2： | 1 |
| 11 | Fluorescence cystoscopy following intravesical instillation of 5-aminolevulinic acid:a new procedure with high sensitivity for detection of hardly visible urothelial neoplasias显示文摘 | Kriegmair M Stepp H Steinbach P | 1995 | Urol Int1995，55，4： | 1 |
| 12 | The effect of celecoxib,a cyclooxygenase-2 inhibitor,in familial adenomatous polyposis显示文摘 | Steinbach G Lynch P M Philips R | 2000 | N Engl J Med2000，342，26： | 1 |
| 13 | A phase field con- cept for multiphase systems显示文摘 | Steinbach I Pezzolla F Nestler B | 1996 | Physica D1996，94，3： | 1 |
| 14 | Muhiphase-Field Approach for Muhicomponent Alloys with Extrapolation Scheme for Numerical Application显示文摘 | Eiken J Botger B Steinbach I | 2006 | Physical Reviewe E2006，，06： | 1 |
| 15 | The effect of rotating magnetic fields on the microstructure of directionally solidified Al-Si-Mg alloys显示文摘 | Steinbach S Ratke L | 2005 | Materials Science and Engineering A2005，，： | 1 |
| 16 | Scavenger receptors are associated with cellular interactions of S100A12 in vitro and in vivo 显示文摘 | Hoppmann S Steinbach J Pietzseh J | 2010 | Int J Biochem Cell Biol2010，42，5： | 1 |
| 17 | Basic previous term hydrol- ysis next term 2- fluoro-1,3,4,6-tetra-O-acetyl-image-glu- cose in the preparation of 2-显示文摘 | Fuchtner F Steinbach J Mading P | 1996 | Appl Radiat Isot1996，47，： | 1 |
| 18 | The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis 显示文摘 | Rau B Steinbach G Gansauge F | 1997 | Gut1997，41，： | 1 |
| 19 | The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis 显示文摘 | Steinbach G Lynch PM Phillips RK | 2000 | N Engl J Med2000，342，26： | 1 |
| 20 | Thermal assessment of clinker coolers显示文摘 | GARDEIK H O Wiesbaden ROSEMANN H STEINBACH V | 1987 | ZKG-international1987，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员