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| 1 | Type 2 diabetes is associated with a worse functional outcome of ischemic stroke显示文摘AIM: To assess whether ischemic stroke severity and outcome is more adverse in patients with type 2 diabetes mellitus(T2DM). METHODS: Consecutive patients hospitalized for acute ischemic stroke between September 2010 and June 2013 were studied prospectively(n = 482; 40.2% males, age 78.8 ± 6.7 years). T2 DM was defined as self-reported T2 DM or antidiabetic treatment. Stroke severity was evaluated with the National Institutes of Health Stroke Scale(NIHSS) score at admission. The outcome was assessed with the modified Rankin scale(m RS) score at discharge and with in-hospital mortality. Adverse outcome was defined as m RS score at discharge ≥ 2 or in-hospital death. The length of hospitalization was also recorded.RESULTS: T2 DM was present in 32.2% of the study population. Patients with T2 DM had a larger waist circumference, higher serum triglyceride and glucose levels and lower serum high-density lipoprotein cholesterol levels as well as higher prevalence of hypertension, coronary heart disease and congestive heart failure than patients without T2 DM. On the other hand, diabetic patients had lower low-density lipoprotein cholesterol levels and reported smaller consumption of alcohol than non-diabetic patients. At admission, the NIHSS score did not differ between patients with and without T2DM(8.7 ± 8.8 and 8.6 ± 9.2, respectively; P = NS). At discharge, the m RS score also did not differ between the two groups(2.7 ± 2.1 and 2.7 ± 2.2 in patients with and without T2 DM, respectively; P = NS). Rates of adverse outcome were also similar in patients with and without T2DM(62.3% and 58.5%, respectively; P = NS). However, when we adjusted for the differences between patients with T2 DM and those without T2 DM in cardiovascular risk factors, T2 DM was independently associated with adverse outcome [relative risk(RR) = 2.39; 95%CI: 1.21-4.72, P = 0.012]. Inhospital mortality rates did not differ between patients with T2 DM and those without T2DM(9.0% and 9.8%, respectively; P = NS). In multivariate analysis adjusting for the difference in cardiovascular risk factors between the two groups, T2 DM was again not associated with in-hospital death. CONCLUSION: T2 DM does not appear to affect ischemic stroke severity but is independently associated with a worse functional outcome at discharge. | Konstantinos Tziomalos Marianna Spanou Stella D Bouziana Maria Papadopoulou Vasilios Giampatzis Stavroula Kostaki Vasiliki Dourliou Maria Tsopozidi Christos Savopoulos Apostolos I Hatzitolios | 2014 | World Journal of Diabetes2014，5，6： | 15 |
| 2 | Antidiarrheal activity of Pterocarpus erinaceus methanol leaf extract in experimentally-induced diarrhea显示文摘Objective:To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo.Methods:The methanol leaf extract of Ptemcarpus erinaceus was evaluated using different doses(100,200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea,charcoal meal transit lime and castor oil-induced enteropooling in different groups of albino Wistar mice.The activity of the extract at different doses were compared to diphenoxylate(3 mg/kg) and atropine sulphate(3 mg/kg) which were used as standard reference drugs and also to the distilled water administered negative control group of mice.Results:The extract at the doses used caused a significant(P< 0.01) reduction in the wet faeces passed by the mice in the castor oil-induced diarrhea,decreased the distance travelled by the charcoal meal by up to 54.8%and also caused a dose dependent and significant(P< 0.001) reduction in the intraluminal fluid accumulation in the castor oil-induced enteropooling. Conclusions:Our results indicate that Pterocarpits erinaceus extract produced significant antidiarrheal activity and the action may attribute to inhibition of gastrointestinal movement and fluid secretion. | Ezeja Maxwell I Ezeigbo Ihechiluru I Madubuike Kelechi G Udeh Nkiru E Ukweni Iheanacho A Akomas Stella C Ifenkwe Daniel C | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 3 |
| 3 | 在不含酒精的脂肪肝疾病和尖锐 ischemic 击严厉和结果之间的协会显示文摘 AIM:To evaluate the association of nonalcoholic fatty liver disease(NAFLD)with acute ischemic stroke severity and in-hospital outcome.METHODS:We prospectively studied all patients who were admitted in our Department with acute ischemic stroke between September 2010 and August 2012(n=415;39.5%males,mean age 78.8±6.6 years).The severity of stroke was assessed with the National Institutes of Health Stroke Scale(NIHSS)score at admission.NALFD was defined as serum alanine aminotransferase and/or aspartate aminotransferase levels above the upper limit of normal in the absence of other causes of elevated aminotransferases levels[chronic hepatitis B or C,drug toxicity,increased alcohol consumption(>21 and>14 drinks per week in men and women,respectively),cholestatic diseases or rhabdomyolysis].The outcome was assessed with the modified Rankin scale(mRS)score at discharge and in-hospital mortality.Adverse outcome was defined as mRS score at discharge≥2.Dependency at discharge was defined as mRS score between 2 to 5.RESULTS:NAFLD was present in 7.7%of the study population.Patients with NAFLD had lower serum high-density lipoprotein cholesterol and higher triglyceride levels than patients without NAFLD(P<0.05 for both comparisons).Demographic data,the prevalence of other cardiovascular risk factors and the prevalence of established CVD did not differ between the two groups.At admission,the NIHSS score did not differ between patients with and without NAFLD(6.3±6.4and 8.8±9.6,respectively;P=NS).At discharge,the mRS score did not differ between the two groups(1.9±2.2 and 2.6±2.2 in patients with and without NAFLD,respectively;P=NS).Rates of dependency at discharge were also similar in patients with and without NAFLD(36.8%and 55.0%,respectively;P=NS)as were the rates of adverse outcome(42.9%and58.6%,respectively;P=NS).In-hospital mortality rates also did not differ between the 2 groups(8.0%and 7.0%in patients with and without NAFLD,respectively;P=NS).CONCLUSION:The presence of NAFLD in patients admitted for acute ischemic stroke does not appear to be associated with more severe stroke or with worse in-hospital outcome. | Konstantinos Tziomalos Vasilios Giampatzis Stella D Bouziana Marianna Spanou Maria Papadopoulou Athinodoros Pavlidis Stavroula Kostaki Andreas Bozikas Christos Savopoulos Apostolos I Hatzitolios | 2013 | World Journal of Hepatology2013，5，11： | 2 |
| 4 | Enalapril prevents fatty liverin nephritic rats显示文摘 | Toblli JE Ferder L Stella I | 2002 | J Nephrol2002，15，4： | 1 |
| 5 | The effect of different antihypertensive drugs on cavernous tissue in experimental chronic renal insufficiency显示文摘 | Toblli JE Stella I Mazza ON | 2006 | Journal of Nephrology2006，19，4： | 1 |
| 6 | Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression显示文摘 | Stella Pelengaris Michael Khan Gerard I Evan | 2002 | Cell2002，，3： | 1 |
| 7 | Enalapril prevents fatty liver in nephrotic rats显示文摘 | TOBLLI J E FERDER L STELLA I | 2002 | J Nephrol2002，15，4： | 1 |
| 8 | Protective effect of the inhibition of the renin-angiotensin system on aging显示文摘 | Basso N Pag lia N Stella I | 2005 | Regul Pept2005，128，： | 1 |
| 9 | Cost-effective- ness of Implantable Cardioverter Defibrillators in Brazil in the Public and Private Sectors显示文摘 | Ribeiro R A Stella S F Zimerman L I | 2010 | Arq Bras Cardiol2010，95，5： | 1 |
| 10 | Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal en- vironment in a mouse model of endometriosis 显示文摘 | Bilotas M Meresman G Stella I | 2010 | Fertil Steril2010，93，： | 1 |
| 11 | Hydroehemistry and nutrients dynamic in the Suqul'a river urban 显示文摘 | Andrea I P Stella M F Gabriela A S | 2011 | Environ Earth Science2011，3，： | 1 |
| 12 | Morphological changes in cavernous tissue in spontaneously hypertensive rats显示文摘 | Toblli JE Stella I Inserra F | | 0，，6： | 1 |
| 13 | Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal en- vironment in a mouse model of endometriosis 显示文摘 | Bilotas M Meresman G Stella I | 2010 | Fertil Steril2010，93，： | 1 |
| 14 | Neurobiological correlates of apathy in Alzheimer's disease and mild cognitive impairment:a critical review显示文摘 | Stella F Radanovic M Aprahamian I | 2014 | J Alzheimers Dis2014，39，： | 1 |
| 15 | Morphological changes in cavernous tissue in spontaneously hypertensive rats显示文摘 | Stella I Inserra F | 2000 | Am J Hypertens2000，13，61： | 1 |
| 16 | The very low mass X-ray binary pulsars:A new class of sources? 显示文摘 | MEREGHEWI'I S STELLA L | 1995 | Ap J1995，422，： | 1 |
| 17 | Mycobacteriophages as versatile tools for genetic manipulation of mycobacteria and development of simple methods for diagnosis of mycobacterial diseases显示文摘 | Stella E J de-la-Iglesia A I Morbidoni H R | | 0，，01： | 1 |
| 18 | Effects of anglo tensin Ⅱ subtype 1 receptor blockade by losartan on tubuloin terstitial lesions caused by hyperoxaluria显示文摘 | TOBLLI J E FERDER L STELLA I | 2002 | Journal of Urology2002，168，41： | 1 |
| 19 | Ischemia-reperfusion: a look from yeast mitochondria显示文摘 | Stella C Burgos I Chapela S | 2011 | Curr Med Chem2011，18，23： | 1 |
| 20 | Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis显示文摘 | Bilotas M Meresman G Stella I | 2010 | Fertil Steril2010，93，8： | 1 |
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