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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | The facial nerve in medial acoustic neuromas 显示文摘 | Strauss C | 2002 | J Neurosurg2002，97，5： | 1 |
| 3 | Mechanical/thermal de- watering-a new process for the utilisation of ligite for power generation显示文摘 | Strauss K Bergins C Wild T | 2006 | Fuel2006，，2： | 1 |
| 4 | Functional and pheno- typic characteristics of CD4 ICD25 high Foxp3+ Treg clones obtained from peripheral blood of patients with cancer显示文摘 | Strauss L Bergrnann C Whiteside TL | 2007 | Int J Cancer2007，，： | 1 |
| 5 | Temporal alterations in cellular Bax:Bcl-2 ratio following traumatic brain injury in the rat显示文摘 | Raghupathi R Strauss KI Zhang C | 2003 | J Neurotrauma2003，20，5： | 1 |
| 6 | A new rank based version of the ant system:A computational study显示文摘 | Bullnheimer B Hartl R F Strauss C | 1999 | Central European Journal for Operations Research and Economics1999，7，1： | 1 |
| 7 | A new rank based version of the ant system: A computational study显示文摘 | Bullnheimer B Hartl R F Strauss C | 1999 | Central European J for Operations Research and Economics1999，7，1： | 1 |
| 8 | Contralateral hearing loss as an effect of venous congestion at the ipsilateral inferior colliculus after microvascular decompression: report of a case 显示文摘 | Strauss C Naraghi R BischoffB | 2000 | J Neurol Neurosurg Psychiatry2000，69，5： | 1 |
| 9 | Surface termination of BaTiO3 (001) single crystals: A combined electron spectroscopic and theoretical study 显示文摘 | Berlich A Strauss H Langheinrich C | 2011 | Surface Science2011，，605： | 1 |
| 10 | Hydroxylated linalool derivatives as percursors of volatile monoterpenes of Muscat grapes显示文摘 | Williams P J Strauss C R Wilson B | 1980 | J Agric Food Chem1980，28，： | 1 |
| 11 | Expression of bFGF, VEGF and c-met and their correlation with microvessel density and progression in prostate carcinoma 显示文摘 | Strohmeyer D Strauss F Rossing C | 2004 | Antieancer Res2004，24，3： | 1 |
| 12 | Computed tomography versus watersolube contrast swallow in the detectionof intra thoracic anastomotic leak complicating esophagogastrectomy (IvorLewis): a prospective study in 97patients 显示文摘 | Strauss C Mal F Pemiceni T | 2011 | Ann Surg2011，251，4： | 1 |
| 13 | A unique subset of CD4+ CD25highFoxp3+ T cells secreting interleu- kin-10 and transforming growthfactor-betal mediates sup- pression in the tumor microenvironment 显示文摘 | Strauss L Bergmann C Szczepanski M | 2007 | Clin Can- cerRes2007，13，151： | 1 |
| 14 | Expression of ICOS on human melanoma-infiltrating CD4+ CD25high Foxp3 + T regulatory cells:implications and impact on tumor-mediated immune suppression显示文摘 | Strauss L Bergmann C Szczepanski M J | 2008 | J Immunol2008，180，5： | 1 |
| 15 | Detection and characterization of hibernation myocardium 显示文摘 | Mari C Strauss WH | 2002 | Nucl Med Commun2002，23，4： | 1 |
| 16 | Expression of bFGF,VEGF and c-met and their correlation with microvessel density and progression in prostate carcinoma显示文摘 | STROHMEYER D STRAUSS F ROSSING C | 2004 | Anti Cancer Res2004，24，3： | 1 |
| 17 | Gibberellins regulatelateral root formation in Populus through interactions with auxinand other hormones 显示文摘 | GOU J Q STRAUSS S H TSAI C J | 2010 | Plant Cell2010，22，3： | 1 |
| 18 | An Improved Ant system Algorithm for the Vehicle Routing Problern显示文摘 | Bullnheimer B Hartl R F Strauss C | 1999 | Annals of Opera- tions Research1999，89，10： | 1 |
| 19 | The influence of resilience on fatigue in cancer patients undergoing radiation therapy (RT) 显示文摘 | Strauss B Brix C Fischer S | 2007 | J Cancer Res Clin Oneol2007，133，8： | 1 |
| 20 | An improved ant system algorithm for the vehicle routing problem显示文摘 | BULLNHEIMER B HARD R F STRAUSS C | 1999 | Annual of Operations Research1999，89，： | 1 |
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