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| 1 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 2 | Loss of the tissue- specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma 显示文摘 | Sturm I Stephan C Gillissen B | 2006 | Cell Death Differ2006，13，4： | 1 |
| 3 | Schottky barrier heights of Pt and Ir silicides formed on Si/SiGe measured by internal photoemission显示文摘 | JIMENEZ J R XIAO X STURM J C | 1994 | J Appl Phys1994，75，10： | 1 |
| 4 | Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins显示文摘 | Ho M C Sturm M B Almo S C | 2009 | Proc Natl Acad Sci U S A2009，106，20： | 1 |
| 5 | NMR signal assignment of 22-deoxocucurbitacin D and cucurbitacin D from Ecballium elaterium L (Cucurbitaceae) 显示文摘 | Seger C Sturm S Haslinger E | 2005 | Monatsh Chen2005，136，9： | 1 |
| 6 | Silicide/Si1-xGex Schottky barrier long-wavelength infrareddetectors显示文摘 | XIAO X STURM J C PARIHAR S R | 1992 | Electron Device Meeting Technical Digest1992，，1316： | 1 |
| 7 | Local tuning of organic light emitting diode color by dye droplet application显示文摘 | HEBNER T R STURM J C | 1998 | Applied Physics Letters1998，73，13： | 1 |
| 8 | External coupling efficiency in planar organic light-emitting devices显示文摘 | Lu M H Sturm J C | 2001 | Appl Phys Lett2001，78，： | 1 |
| 9 | CMY- 20, a novel AmpC-type β-1actamase from South African clinical Escherichia coli isolates 显示文摘 | Mocktar C Govinden U Sturm AW | 2008 | Diagn Microbiol Infect Dis2008，60，4： | 1 |
| 10 | Chemical,physical and microbial properties and microbial diversity in manufactured soils produced from co-composting green waste and biosolids显示文摘 | BELYAEVA O N HAYNES R J STURM E C | 2012 | Waste management2012，32，12： | 1 |
| 11 | Analytical aspects of plant metabolite profilingplatforms:Current standings and future aims显示文摘 | SEGER C STURM S | 2007 | Proteome Research2007，，6： | 1 |
| 12 | Grade-base Si/Si1-xGex/Si heterojunction bipolar transistors grown by rapid thermal chemical vapor deposition with near-ideal electrical characteristics 显示文摘 | | 1991 | IEEE Electron Device Lett1991，12，6： | 1 |
| 13 | Voltammetric oxidation of hantzsch 1,4-dihydropyridines in protic media:substituent effect on positions 3,4,5 of the heterocyclic ring显示文摘 | Arguello J Nunez-Vergara L J Sturm J C | 2004 | Electrochimica Acta2004，49，： | 1 |
| 14 | Casting process simulation--from the idea 30 years ago to reality today 显示文摘 | Hansen P N Flender E Sturm J C | 2009 | International Foundry Research2009，61，4： | 1 |
| 15 | Surface modification of indium tin oxide by plasma treatment:an effective method to improve the effciency,brightness,and reliability of organic light emitting devices显示文摘 | Wu C C Wu C I Sturm J C | 1997 | Appl Phys Lett1997，70，11： | 1 |
| 16 | Waveform design and signalprocessing aspects for fusion of wireless communications andradar sensing 显示文摘 | Sturm C and Wiesbeck W | 2011 | Proceedings of the IEEE2011，99，7： | 1 |
| 17 | In vivo mo- lecular imaging of Barrett' s esophagus with confocal la- ser endomicroscopy显示文摘 | Sturm M B Piraka C Elmunzer B J | 2013 | Gastroenterology2013，145，1： | 1 |
| 18 | On-chip natural assembly of silicon photonic bandgap crystals显示文摘 | Vlasov Y A 130 X Z Sturm J C | 2001 | Nature2001，414，： | 1 |
| 19 | Intraamniotic ethacridine PGE1 in second trimester termination of pregnancy显示文摘 | Berg C Ludwig M Sturm N et lactate instillation versus vaginal al | 2006 | Eur J Obstet Gynecol Reprod Biol2006，126，2： | 1 |
| 20 | Fusions of Description Logics and Abstract Description Systems显示文摘 | Baader F Lutz C Sturm H | 2003 | Journal of Artificial Intelligence Research2003，16，2： | 1 |
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