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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Grafting of methymethacrylate onto cellulose nitrate initiated by benzoyl peroxide 显示文摘 | Sudhakar D Srinivasan K S V Joseph K T | 1981 | Polymer1981，22，4： | 1 |
| 3 | Bamboo livelihood development planning, monitoring and analysis through GIS and remote sensing显示文摘 | BHARADWAJ S P SIVA S SUDHAKAR M | 2003 | Journal of Bamboo and Rattan2003，2，4： | 1 |
| 4 | Two-and three-dimen- sional speckle tracking echocardiography:clinical applications and future directions 显示文摘 | Biswas M Sudhakar S Nanda NC | 2013 | Echocardiography2013，30，1： | 1 |
| 5 | Hydroxylation of Phenol over TS-2,a Titanium Silicate Molecular Sieve显示文摘 | SUDHAKAR REDDY J SIVASANKER S RATNASAMY P | 1992 | Journal of Molecular Catalysis1992，71，3： | 1 |
| 6 | Vapour phase aniline alkylation activity and selectivity over H -ZSM -5 显示文摘 | Narayanan S DurgakumariV Sudhakar A R | 1994 | Appl Catal A1994，111，2： | 1 |
| 7 | In-silico designing of a potent analogue against HIV-1 Nef protein and protease by predicting its interaction network with host cell proteins 显示文摘 | Pal S Mishra M Sudhakar DR | 2013 | J Pharm Bioallied Sci2013，5，1： | 1 |
| 8 | Two-and three-dimensional speckle tracking echocardiography: clinical applications and future directions 显示文摘 | Biswas M Sudhakar S Nanda NC | 2013 | Echocardiography2013，30，1： | 1 |
| 9 | Two-and three-dimensional speckle tracking echocardiography:clinical applications and future directions显示文摘 | Biswas M Sudhakar S Nanda NC | 2013 | Echocardiography2013，30，1： | 1 |
| 10 | Phenolic and steroidal constituents of the lichen Usnea longissima显示文摘 | Mallavadhani U V A V S Sudhakar Anita Mahapatra | 2004 | Biochemical Systematics and Ecology2004，32，： | 1 |
| 11 | Effect of Water Stress on Photosynthesis in Two Mulberry Genotypes with Different droujght Tolerance显示文摘 | Ramanjulu S Sreenivasulu N Sudhakar C | 1998 | Photosynthetiea1998，35，27： | 1 |
| 12 | Influence of argon di lution on the growth of amorphous to ultra nanocrystalline silicon filmsusing VHF PECVD process 显示文摘 | Gope J Kumar S Sudhakar S et aI | 2013 | J Alloys Compd2013，577，： | 1 |
| 13 | Molecular analy- sis of cataract families in India: new mutations in the CRYBB2 and GJA3 genes and rare polymorphisms 显示文摘 | Santhiya S T Kumar G S Sudhakar P | 2010 | Mol Vis2010，16，： | 1 |
| 14 | Simultaneous robot/world and tool/flange calibration by solving homogeneous transformation equations of the form AX=YB显示文摘 | Hanqi Z Roth Z S Sudhakar R | 1994 | IEEE Transactions on Robotics and Automation1994，10，4： | 1 |
| 15 | Role of single photon emis- sion computed tomography in epilepsy显示文摘 | Jayalakshmi S Sudhakar P Panigrahi M | 2011 | Int J Mol Imaging2011，2011，80： | 1 |
| 16 | Modelling of an Agricultural Watershed using Remote Sensing and a Geographic Information System显示文摘 | PANDEY V K PANDA S N SUDHAKAR S | 2005 | Biosystems Engineering2005，90，3： | 1 |
| 17 | Coherency calculations in the presence of structural dip 显示文摘 | Marfurt J J Sudhakar V Gersztenkom A Crawford K D Nissen S E | 1999 | Geophysics1999，64，1： | 1 |
| 18 | Role of p73 in regulating human caspase-1 gene transcription induced by Interferon-γ and Cisplatin显示文摘 | Jain N Gupta S Sudhakar CH | 2005 | J Biol Chem2005，280，36： | 1 |
| 19 | Localization of impacted permanent maxillary canine using single panoramic radiograph 显示文摘 | Sudhakar S Patil K Mahima V G | 2009 | IndianJ Dent Res2009，20，3： | 1 |
| 20 | Effects of shrink film wrapping and storage temperature on the shelf life and quality of pomegranate fruits cv. Ganesh显示文摘 | S Nanda D.V Sudhakar Rao Shantha Krishnamurthy | 2001 | Postharvest Biology and Technology2001，，1： | 1 |
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