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| 1 | Fundamental mechanisms and phenomena of clathrate hydrate nucleation显示文摘Insights into the mechanism of hydrate nucleation are of great significance for the development of hydrate-based technologies,hydrate relevant flow assurance,and the exploration of in situ natural gas hydrates.Compared with the thermodynamics of hydrate formation,understanding the nucleation mechanism is challenging and has drawn substantial attention in recent decades.In this paper,we attempt to give a comprehensive review of the recent progress of studies of clathrate hydrate nucleation.First,the existing hypotheses on the hydrate nucleation mechanism are introduced and discussed.Then,we summarize recent experimental studies on induction time,a key parameter evaluating the velocity of the nucleation process.Subsequently,the memory effect is particularly discussed,followed by the suggestion of several promising research perspectives. | Jinlong Cui Zhenfeng Sun Xiaohui Wang Bin Yu Shudong Leng Guangjin Chen Changyu Sun | 2019 | Chinese Journal of Chemical Engineering2019，27，9： | 11 |
| 2 | Robust high-resolution beam-forming based on high order cross sensor processing method显示文摘In order to obtain the robust high-resolution beamforming, a high order cross sensor processing(CSP) approach is developed. According to the relation ship between the target bearing and the phase difference of each element receiving signal, this method exploits the property that the same diagonal of covariance matrix with the same phase difference and obtains(2M-1)(N-1)virtual elements(N is the original array number) by executing M order CSP. The extended virtual elements can effectively increase the physical aperture of linear array, reduce the main lobe width of beam-forming, and improve the bearing resolution. The CSP method accumulates the data on the same sub-diagonal of the covariance matrix, which can decrease the impact of background noise on beam-forming. The theoretical analysis and experimental results both show that this method has high resolution in bearing estimation, compared with the MUSIC method, which has better robustness under the lower signal-to-noise ratio(SNR). | Enming Zheng Xinhua Chen Huabing Yu Changyu Sun | 2015 | Journal of Systems Science & Complexity2015，28，5： | 5 |
| 3 | A continuous and high-efficiency process to separate coal bed methane with porous ZIF-8 slurry:Experimental study and mathematical modelling显示文摘Coal bed methane has been considered as an important energy resource.One major difficulty of purifying coal bed methane comes from the similar physical properties of CH_4 and N_2.The ZIF-8/water-glycol slurry was used as a medium to separate coal bed methane by fluidifying the solid adsorbent material.The sorption equilibrium experiment of binary mixture(CH_4/N_2)and slurry was conducted.The selectivity of CH_4 to N_2 is within the range of 2-6,which proved the feasibility of the slurry separation method.The modified Langmuir equation was used to describe the gas-slurry phase equilibrium behavior,and the calculated results were in good agreement with the experimental data.A continuous absorption-adsorption and desorption process on the separation of CH_4/N_2 in slurry is proposed and its mathematical model is also developed.Sensitivity analysis is conducted to determine the operation conditions and the energy performance of the proposed process was also evaluated.Feed gas contains 30 mol%of methane and the methane concentration in product gas is 95.46 mol%with the methane recovery ratio of 90.74%.The total energy consumption for per unit volume of product gas is determined as 1.846 kWh Nm^(-3).Experimental results and process simulation provide basic data for the design and operation of pilot and industrial plant. | Wan Chen Xiaonan Guo Enbao Zou Mengling Luo Mengzijing Chen Mingke Yang Hai Li Chongzhi Jia Chun Deng Changyu Sun Bei Liu Lanying Yang Guangjin Chen | 2020 | Green Energy & Environment2020，5，3： | 5 |
| 4 | Transfer alignment of shipborne inertial-guided weapon systems显示文摘The transfer alignment problem of the shipborne weapon inertial navigation system (INS) is addressed. Specifically, two transfer alignment algorithms subjected to the ship motions induced by the waves are discussed. To consider the limited maneuver level performed by the ship, a new filter algorithm for transfer alignment methods using velocity and angular rate matching is first derived. And then an improved method using integrated velocity and integrated angular rate matching is introduced to reduce the effect of the ship body flexure. The simulation results show the feasibility and validity of the proposed transfer alignment algorithms. | Sun Changyue Deng Zhenglong | 2009 | Journal of Systems Engineering and Electronics2009，20，2： | 4 |
| 5 | Drag reduction and shear resistance properties of ionomer and hydrogen bond systems based on lauryl methacrylate显示文摘Based on molecular dynamics simulation results,a lauryl methacrylate polymer with drag reduction and shear resistance properties was designed,and synthesized by emulsion polymerization using 2-vinyl pyridine and methyl methacrylate as the polar polymerization monomer.After ionization of lauryl methacrylate polymer,an ion-dipole interaction based drag reduction agent (DRA) was obtained.The existence of ion-dipole interaction was proven through characterization of the drag-reducing agent from its infrared (IR) spectrum.The pilot-scale reaction yield of the DRA under optimum conditions was investigated,and the drag reduction and shear resistance properties were measured.The results show that:1) The ion-dipole or hydrogen bonding interaction can form ladder-shaped chains,therefore the synthesized DRA has shear resistance properties;2) The larger the molecular weight (MW) and more concentrated the distribution of MW,the better the drag reduction efficiency and the performance of the ionomer system was superior to that of the hydrogen bonding system;3) With increasing shear frequency,the drag-reduction rates of both the DRAs decreased,and the drag reduction rate of the ionomer system decreased more slowly than of the corresponding hydrogen bonding system.From the point of view of drag reduction rate and shear resistance property,the ionomer system is more promising than the hydrogen bonding | Yu Ping Li Changyu Zhang Changqiao Chen Shiwei Fang Shu Sun Hui | 2011 | Petroleum Science2011，8，3： | 3 |
| 6 | A detecting method for line-spectrum target by fusing output DC jump to fluctuations ratio of sub-band spatial spectrum and beam space显示文摘The low frequency line components of the radiated noise from an underwater target usually have both high spectrum level and sustained stability.This feature could be used to increase the detection performance of conventional broadband energy integration method.The required spectrum level is theoretically discussed when the detection performance of the known line detection is better than that of broadband energy integration method.Under the condition of the target can be detected in line spectrum band,the relationship between the line spectrum level and signal to noise ratio(SNR)is also discussed.This paper proposes a line spectrum target detection method that a matrix using DC jump to fluctuations ratios of sub-band spatial spectrum and beam space output is constructed.This matrix acts as a filter that the line spectrum target with certain frequency and azimuth is passed at most.By fusing with the other sub band results,the conventional detection performance can be improved.At the same time,the applicable condition and detection performance are analyzed in the paper.The simulation and the sea trial data processing results show that the algorithm can effectively extract weak goal line spectrum target under the condition of multi-interference.The algorithm doesn't need multi-frame statistics and the detection performance is closer to the optimal line spectrum method. | DAI Wenshu CHEN Xinhua SUN Changyu YU Huabing | 2015 | Chinese Journal of Acoustics2015，34，3： | 3 |
| 7 | Evaluating the Capabilities of Soil Enthalpy, Soil Moisture and Soil Temperature in Predicting Seasonal Precipitation显示文摘Soil enthalpy(H) contains the combined effects of both soil moisture(w) and soil temperature(T) in the land surface hydrothermal process. In this study, the sensitivities of H to w and T are investigated using the multi-linear regression method.Results indicate that T generally makes positive contributions to H, while w exhibits different(positive or negative) impacts due to soil ice effects. For example, w negatively contributes to H if soil contains more ice; however, after soil ice melts,w exerts positive contributions. In particular, due to lower w interannual variabilities in the deep soil layer(i.e., the fifth layer), H is more sensitive to T than to w. Moreover, to compare the potential capabilities of H, w and T in precipitation(P) prediction, the Huanghe–Huaihe Basin(HHB) and Southeast China(SEC), with similar sensitivities of H to w and T,are selected. Analyses show that, despite similar spatial distributions of H–P and T –P correlation coefficients, the former values are always higher than the latter ones. Furthermore, H provides the most effective signals for P prediction over HHB and SEC, i.e., a significant leading correlation between May H and early summer(June) P. In summary, H, which integrates the effects of T and w as an independent variable, has greater capabilities in monitoring land surface heating and improving seasonal P prediction relative to individual land surface factors(e.g., T and w). | Changyu ZHAO Haishan CHEN Shanlei SUN | 2018 | Advances in Atmospheric Sciences2018，35，4： | 3 |
| 8 | Histopathological Study of Trabeculum after Excimer Laser Trabeculectomy ab Interno显示文摘Purpose: To study the clinical manifestations and histopathologic changes of trabeculum after excimer laser trabeculectomy ab interno (ELT), and to investigate the mechanisms of ELT in reducing intraocular pressure.
Methods : ELT was performed on ten rabbit eves and postoperative responses were documented. Comeoscleral tissue samples were harvested consecutively each week until the 5th postoperative week and these samples were examined under light and electrical microscopy.
Results: Mild stimulation signs were present postoperatix'ely in nine of ten eyes, but no serious complications were experienced. Obvious inflammation was observed in one rabbit eye as a result of iris damage during the surgical manipulations. Local kactures on the trabecular meshwork and openings into Schlemm' s canal were detected in all tissue samples under light microscope. Mitochondria were found to be turgescent and dilated like vacuoles and endoplasmic reticula were found to be dilated under electrical microscope in the early postoperative period. Later, all trabecular cells returned normal and no fihroblast cells were ever detected.
Conclusions: Permanent openings through trabecular meshwork into the inner wall of Schlemm's canal can be created with ELT. The outflow resistance of aqueous humor can be reduced with these openings and intraocular pressure can be controlled thereafter. Eye Science 2001; 17:11 ~ 15. | Shengsong Huang,Minbin Yu,Guangqiang Feng,Ping Zhang,Changyu QiuZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060 , China | 2001 | Eye Science2001，17，1： | 3 |
| 9 | Line spectrum detection algorithm based on the phase feature of target radiated noise显示文摘In order to improve the performance of line spectrum detection,according to the feature that the underwater target radiated noise containing stable line spectrum,the differences of the phase difference between line spectrum and background noise,a weighted line spectrum detection algorithm based on the phase variance is proposed in frequency domain.After phase difference alignment,the phase variance of line spectrum and the phase of background noise,respectively,are small and big in frequency domain,this method utilizes the weighted statistical algorithm to cumulate the frequency spectrum based on the phase variance,which can restrain the background noise disturbance,and enhance the signal to noise ratio(SNR).The theory analysis and experimental results both verify that the proposed method can well enhance the energy of line spectrum,restrain the energy of background noise,and have better detection performance under lower SNR. | Enming Zheng Huabing Yu Xinhua Chen Changyu Sun | 2016 | Journal of Systems Engineering and Electronics2016，27，1： | 3 |
| 10 | Large-eddy simulation of the compressible flow past a tabbed cylinder显示文摘The compressible flow past a tabbed cylinder has been studied numerically using large-eddy simulation for a free-stream Mach number M∞=0.75 and a Reynolds number based on the diameter Re=2×105. Because of the passive control of the flow past a tabbed cylinder, the mean drag coefficient of tabbed cylinder is less than that of a corresponding circular cylinder with a drag reduction up to 33%. The fluctuating lift coefficient is greatly suppressed to be nearly zero. Drag reduction due to the shearing process prevails over that due to the compressing process in this flow. Through investigating the mechanisms relevant to passive control of the tab, it is found that suppression of the shear layer instability can lead to a higher-base-pressure distribution, which can reasonably be associated with drag reduction and suppression of the lift fluctuations. The analysis of convective Mach number and self-sustained oscillations phenomenon inside the shear layers indicates that both the compressible effect and high-frequency forcing result in suppression of the shear layer instability of tabbed cylinder. | XU ChangYue ZHAO LiQing SUN JianHong | 2012 | Chinese Science Bulletin2012，57，24： | 3 |
| 11 | Experimental investigation of methane hydrate decomposition by depressurizing in porous media with 3-Dimension device显示文摘In order to simulate the behavior of gas hydrate formation and decomposition,a 3-Dimension experimental device was built,consisting of a high-pressure reactor with an inner diameter of 300 mm,effective height of 100 mm,and operation pressure of 16 MPa.Eight thermal resistances were mounted in the porous media at different depthes and radiuses to detect the temperature distribution during the hydrate formation/decomposition.To collect the pressure,temperature,and flux of gas production data,the Monitor and Control Generated System(MCGS) was used.Using this device,the formation and decomposition behavior of methane hydrate in the 20 ~ 40 mesh natural sand with salinity of 3.35 wt% was examined.It was found that the front of formation or decomposition of hydrate can be judged by the temperature distribution.The amount of hydrate formation can also be evaluated by the temperature change.During the hydrate decomposition process,the temperature curves indicated that the hydrate in the top and bottom of reactor dissociated earlier than in the inner.The hydrate decomposition front gradually moved from porous media surface to inner and kept a shape of column form,with different moving speed at different surface position.The proper decomposition pressure was also determined. | Kehua Su Changyu Sun Xin Yang Guangjin Chen Shuanshi Fan | 2010 | Journal of Natural Gas Chemistry2010，19，3： | 3 |
| 12 | Clinical significance of miRNA-106a in non-small cell lung cancer patients who received cisplatin combined with gemcitabine chemotherapy显示文摘Objective:Research has demonstrated that microRNA(miR)-106a is related to cisplatin resistance.We investigated the expression of miR-106a in the serum of patients with non-small cell lung cancer(NSCLC)and their sensitivity to chemotherapy by cisplatin combined with gemcitabine.Methods:Eighty-five NSCLC patients,who completed four cycles of gemcitabine and cisplatin chemotherapy,volunteered for this study and their serum samples were collected.Serum samples from 60 healthy subjects were used as controls.Real-time quantitative polymerase chain reaction(real-time q PCR)was used to quantify the level of miR-106a in the serum.Demographic and survival data of these patients were collected for the analysis.Results:The expression of miR-106a in the serum of NSCLC patients was significantly higher than that of healthy subjects(P<0.001).The expression of miR-106a was not correlated with patients'gender,age,tumor size,lymphatic metastasis,and pathological types;but was correlated with patients'tumor staging(P=0.003).After chemotherapy,serum miR-106a expression decreased in patients.The decrease in miR-106a expression in the chemotherapy-sensitive group was much higher than that in the chemotherapy-resistant group.Survival analysis shows that NSCLC patients with high expression of miR-106a have a poorer prognosis.The overall survival of NSCLC patients in the chemotherapy-sensitive group was significantly higher than that in the chemotherapy-resistant group.Conclusions:High expression of miR-106a may be involved in the development of NSCLC.Mi R-106a has significance in the prognosis of NSCLC.The level of miR-106a in the serum can be a useful parameter in screening for drug resistance during cisplatin-based chemotherapy. | Ye Tian Changyu Sun Limeng Zhang Yuan Pan | 2018 | Cancer Biology & Medicine2018，15，2： | 3 |
| 13 | The interference characteristics of platform and towed body noise in shallow water for active/passive towed array sonar显示文摘拖引的站台噪音的干扰特征源于推进器并且拖引身体因为活跃 / 被动的拖引的数组被分析。在浅水环境,反映的直接波浪和底部 / 海表面飘动,这被显示出将严重影响声纳系统的性能。为以各种各样的参数计算干扰的到达( DOA )的方向的公式例如数组深度,一些拖引电缆线,是干扰噪音的 derived.The 效果因为声纳系统的察觉性能是系统模拟的 described.The 结果为减少这些种干扰的效果提供方法。 | LI Qihu LI Shuqiu SUN Changyu YU Huabing | 2007 | Chinese Journal of Acoustics2007，26，3： | 3 |
| 14 | Angiogenesis in hepatocellular carcinoma:mechanisms and anti-angiogenic therapies显示文摘Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-associated death worldwide.Angiogenesis,the process of formation of new blood vessels,is required for cancer cells to obtain nutrients and oxygen.HCC is a typical hypervascular solid tumor with an aberrant vascular network and angiogenesis that contribute to its growth,progression,invasion,and metastasis.Current anti-angiogenic therapies target mainly tyrosine kinases,vascular endothelial growth factor receptor(VEGFR),and plateletderived growth factor receptor(PDGFR),and are considered effective strategies for HCC,particularly advanced HCC.However,because the survival benefits conferred by these anti-angiogenic therapies are modest,new anti-angiogenic targets must be identified.Several recent studies have determined the underlying molecular mechanisms,including pro-angiogenic factors secreted by HCC cells,the tumor microenvironment,and cancer stem cells.In this review,we summarize the roles of pro-angiogenic factors;the involvement of endothelial cells,hepatic stellate cells,tumor-associated macrophages,and tumor-associated neutrophils present in the tumor microenvironment;and the regulatory influence of cancer stem cells on angiogenesis in HCC.Furthermore,we discuss some of the clinically approved anti-angiogenic therapies and potential novel therapeutic targets for angiogenesis in HCC.A better understanding of the mechanisms underlying angiogenesis may lead to the development of more optimized anti-angiogenic treatment modalities for HCC. | Changyu Yao Shilun Wu Jian Kong Yiwen Sun Yannan Bai Ruhang Zhu Zhuxin Li Wenbing Sun Lemin Zheng | 2023 | Cancer Biology & Medicine2023，20，1： | 3 |
| 15 | 3D Carbon Frameworks for Ultrafast Charge/Discharge Rate Supercapacitors with High Energy‑Power Density显示文摘Carbon-based electric double layer capacitors(EDLCs)hold tremendous potentials due to their high-power performance and excellent cycle stability.However,the practical use of EDLCs is limited by the low energy density in aqueous electrolyte and sluggish diffusion kinetics in organic or/and ionic liquids electrolyte.Herein,3D carbon frameworks(3DCFs)constructed by interconnected nanocages(10-20 nm)with an ultrathin wall of ca.2 nm have been fabricated,which possess high specific surface area,hierarchical porosity and good conductive network.After deoxidization,the deoxidized 3DCF(3DCFDO)exhibits a record low IR drop of 0.064 V at 100 A g^−1 and ultrafast charge/discharge rate up to 10 V s^−1.The related device can be charged up to 77.4%of its maximum capacitance in 0.65 s at 100 A g^−1 in 6 M KOH.It has been found that the 3DCF-DO has a great affinity to EMIMBF4,resulting in a high specific capacitance of 174 F g^−1 at 1 A g^−1,and a high energy density of 34 Wh kg^−1 at an ultrahigh power density of 150 kW kg^−1 at 4 V after a fast charge in 1.11 s.This work provides a facile fabrication of novel 3D carbon frameworks for supercapacitors with ultrafast charge/discharge rate and high energy-power density. | Changyu Leng Zongbin Zhao Yinzhou Song Lulu Sun Zhuangjun Fan Yongzhen Yang Xuguang Liu Xuzhen Wang Jieshan Qiu | 2021 | Nano-Micro Letters2021，13，1： | 2 |
| 16 | The Management of Secondary Glaucoma in Nanophthalmic Patients显示文摘Purpose: To investigate the clinical characteristcs, management of secondary glaucoma in nanophthalmos, and the prevention of its complications.Methods: Retrospectively, 9 cases (17 eyes) with nanophthalmic glaucoma were studied.Results: The axial length of the eyes ranged (14.36 ~ 19.33) mm; All of the cases combined with hyperopia ranged (+7.00~+16.00)D. All 17 eyes had the manifestation like angle-closure glaucoma.The glaucoma was controlled in 9 of 17 eyes at the early stage, which underwent laser iridotomy (4 of 9 eyes also underwent laser iridoplasty). 1 eye underwent ciliary photocoagulation because its visual acuity was lost and the patient complained of pain. The other 7 eyes underwent filtration surgery and 3 of them had permanent loss of vision caused by disastrous complications after the surgery.Conclusions: Management of secondary glaucoma in nanophthalmos is complicated. The laser iris surgery is safe and effective in glaucoma at the early stage. Vortex vein decompression, sclerotectomy or anterior sclerotomy may be performed to reduce disastrous complications. | Shengsong Huang, Minbin Yu, Changyu Qiu, Tiancai YeZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China | 2002 | 眼科学报2002，18，3： | 2 |
| 17 | Numerical investigation of bumps and oscillation in the cylindrical membrane inflation显示文摘 | WANG Conglei SUN Jianhong XU Changyue | 2014 | Applied Mechanics and Materials2014，，： | 1 |
| 18 | An inward and outward natural gas hydrates growth shell model considering intrinsic kinetics,mass and heat transfer显示文摘 | SHI Bohui GONG Jing SUN Changyu | 2011 | Chemical Engineering Journal2011，171，3： | 1 |
| 19 | Interfacial properties of methane/aqueous VC-713 solution under hydrate formation conditions显示文摘 | Peng Baozi Sun Changyu | 2009 | Journal of Interface2009，，336： | 1 |
| 20 | Flow characteristics and rheological properties of natural gas hydrate slurry in the presence of anti-agg显示文摘 | Yah Kele Sun Changyu Chen Jun | 2014 | Chem Eng Sci2014，106，： | 1 |
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