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| 1 | Clinical application of concentrated bone marrow aspirate in orthopaedics:A systematic review显示文摘AIM To examine the evidence behind the use of concentrated bone marrow aspirate(c BMA) in cartilage, bone, and tendon repair; establish proof of concept for the use of cB MA in these biologic environments; and provide the level and quality of evidence substantiating the use of cB MA in the clinical setting.METHODS We conducted a systematic review according to PRISMA guidelines. EMBASE, MEDLINE, and Web of Knowledge databases were screened for the use of cB MA in the repair of cartilage, bone, and tendon repair. We extracted data on tissue type, cB MA preparation, cB MA concentration, study methods, outcomes, and level of evidence and reported the results in tables and text.RESULTS A total of 36 studies met inclusion/exclusion criteria and were included in this review. Thirty-one of 36(86%) studies reported the method of centrifugation and preparation of cB MA with 15(42%) studies reporting either a cell concentration or an increase from baseline. Variation of c BMA application was seen amongst the studies evaluated. Twenty-one of 36(58%) were level of evidence Ⅳ, 12/36(33%) were level of evidence Ⅲ, and 3/36(8%) were level of evidence Ⅱ. Studies evaluated full thickness chondral lesions(7 studies), osteochondral lesions(10 studies), osteoarthritis(5 studies), nonunion or fracture(9 studies), or tendon injuries(5 studies). Significant clinical improvement with the presence of hyaline-like values and lower incidence of fibrocartilage on T2 mapping was found in patients receiving cB MA in the treatment of cartilaginous lesions. Bone consolidation and time to bone union was improved in patients receiving cB MA. Enhanced healingrates, improved quality of the repair surface on ultrasound and magnetic resonance imaging, and a decreased risk of re-rupture was demonstrated in patients receiving cB MA as an adjunctive treatment in tendon repair. CONCLUSION The current literature demonstrates the potential benefits of utilizing c BMA for the repair of cartilaginous lesions, bony defects, and tendon injuries in the clinical setting. This study also demonstrates discrepancies between the literature with regards to various methods of centrifugation, variable cell count concentrations, and lack of standardized outcome measures. Future studies should attempt to examine the integral factors necessary for tissue regeneration and renewal including stem cells, growth factors and a biologic scaffold. | Arianna L Gianakos Li Sun Jay N Patel Donald M Adams Frank A Liporace | 2017 | World Journal of Orthopedics2017，8，6： | 5 |
| 2 | Oxygen and Nitrogen Effects on MC Carbide in K465 Nickel-Base Superalloy显示文摘Effects of oxygen and nitrogen on MC carbide in nickel-base superalloy K465 were investigated, because neither of the two gas elements was found to decide MC carbide morphology monotonically. The morphology of MC carbide under alloy solidified in conventional investment casting condition was observed to transform from script-type to block-type with the total oxygen and nitrogen content (gas content) in samples rising up from 1.2×10-6 mol/g to 2.6×10-6 mol/g. The area fraction and composition of the MC carbide also varied with increase of gas content. However, the morphology of MC carbide kept to be script-type even when gas content was up to 3.4×10-6 mol/g in samples solidified with a much higher cooling rate. These results indicate that effects of gas content on formation of MC carbide can be observed in specimens solidified with low cooling rate, but such changes in MC carbide cannot be found when the cooling rate is high. | Wang L N Zheng Q Sun X F Guan H R Hu Z Q | 2009 | 稀有金属材料与工程2009，38，A03： | 4 |
| 3 | Nephropathy in dietary hyperoxaluria:A potentially preventable acute or chronic kidney disease显示文摘Hyperoxaluria can cause not only nephrolithiasis and nephrocalcinosis,but also renal parenchymal disease histologically characterized by deposition of calcium oxalate crystals throughout the renal parenchyma,profound tubular damage and interstitial inflammation and fibrosis.Hyperoxaluric nephropathy presents clinically as acute or chronic renal failure that may progress to endstage renal disease(ESRD).This sequence of events,well recognized in the past in primary and enteric hyperoxalurias,has also been documented in a few cases of dietary hyperoxaluria.Estimates of oxalate intake in patients with chronic dietary hyperoxaluria who developed chronic kidney disease or ESRD were comparable to the reported average oxalate content of the diets of certain populations worldwide,thus raising the question whether dietary hyperoxaluria is a primary cause of ESRD in these regions.Studies addressing this question have the potential of improving population health and should be undertaken,alongside ongoing studies which are yielding fresh insights into the mechanisms of intestinal absorption and renal excretion of oxalate,and into the mechanisms of development of oxalate-induced renal parenchymal disease.Novel preventive and therapeutic strategies for treating all types of hyperoxaluria are expected to develop from these studies. | Robert H Glew Yijuan Sun Bruce L Horowitz Konstantin N Konstantinov Marc Barry Joanna R Fair Larry Massie Antonios H Tzamaloukas | 2014 | World Journal of Nephrology2014，3，4： | 3 |
| 4 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 5 | PRAK is essential for ras-induced senescence and tumor suppression 显示文摘 | Sun P Yoshizuka N New L | 2007 | Cell2007，128，2： | 1 |
| 6 | Standardizing catch and effort data of the Taiwanese distant-water longline fishery in the western and central Pacific Ocean for bigeye tuna, Thunnus obesus显示文摘 | Su N J Yeh S Z Sun C L Punt A E Chen Y Wang S P | | Fisheries Research0，90，13： | 1 |
| 7 | New parallel randomized algorithms for the traveling salesman problem显示文摘 | Shi L Olafsson S Sun N | 1999 | Computers & Operations Research1999，26，： | 1 |
| 8 | AB5-type hydrogen storage alloy used as anodic materials in borohydride fuel cell显示文摘 | Wang L B Ma C N Sun Y M | 2005 | J Alloy Compd2005，391，： | 1 |
| 9 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 10 | Iridoid glucosides and a C13-norisoprenoid from Lamiophlomis rotata and their effects on NF-κB activation显示文摘 | Zhang F Wu Z J Sun L N | 2012 | Bioorg Med Chem Lett2012，22，13： | 1 |
| 11 | The effects of beta-tricalcium phosphate 3D scaffold in-situ cryopreservation on the migration rate and osteogenie ability of mesenchymal stem cells 显示文摘 | Yang L Sun H Y Qi N M | 2012 | Biotechnology and Bioprocess Engineering2012，17，1： | 1 |
| 12 | Manganese superoxide dismutase (MnSOD) polymorphism, alcohol, cigarette smoking and risk of oesophageal cancer显示文摘 | SUN L KONIG I R HOMANN N | 2009 | Alcohol Alcohol2009，44，4： | 1 |
| 13 | Endothelial cell pseudopods and angiogenesis of breast cancer tumors显示文摘 | CAMERON I L SHORT N SUN L Z | 2005 | Cancer Cell Int2005，5，1： | 1 |
| 14 | Synthesis and biological evaluations of 3-substituted indolin-2-ones:a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases显示文摘 | Sun L Tran N Tang F | 1998 | J Med Chem1998，41，14： | 1 |
| 15 | Redictive model and experimental result for a two-adsorption heat pump显示文摘 | DOUSS N MEUINER F E SUN L M | 1988 | Industrial & Engineering Chemistry Research1988，27，2： | 1 |
| 16 | Expression and functional signifi- cance of Twistl in hepatocellular carcinoma: its role in vasculogenic mimicry 显示文摘 | Sun T Zhao N Zhao X L | 2010 | Hepatology2010，51，2： | 1 |
| 17 | Comparative study of anion polyacrylamide (APAM) adsorption-related fouling o a PVDF UF membrane and a modified PVDF UF membrane 显示文摘 | YiXS Shi W X Yu S L Sun N Jin L M Wang S Zhang B Ma C Sun L P | 2012 | Desalination2012，286，： | 1 |
| 18 | What is more important for enhancing nu- trient bioavailability with biochar application into a sandy soil:Direct or indirect mechanism?显示文摘 | Xu G Wei L L Sun J N | 2013 | Ecological Engineering2013，52，： | 1 |
| 19 | Nirl promotes in- vasion of breast cancer cells by binding to chemokine( C-C mo- tif) ligand 18 through the PI3K/AM/GSK3/Snall signalling pathway显示文摘 | Zhang B Yin C Li H Shi L Liu N Sun Y | 2013 | Eur J Cancer2013，49，18： | 1 |
| 20 | Structure and photocatalytic property of Mo doped TiO2 nanoparti- cles显示文摘 | WANG S BAI L N SUN H M etal | 2013 | Powder Technology2013，244，： | 1 |
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