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| 1 | Development of BCPDA-Eu^3+-BAS Labeled Hepatitis B Surface Antibodies显示文摘 | TAN Wenjia SUN Zhixia XUAN Lili LI Junling XIE Wenbing HE Chengyan PAN Lihua | 2018 | Chemical Research in Chinese Universities2018，34，1： | 4 |
| 2 | Application Research Status and Development Prospect of Microbial Flocculant显示文摘Microbial flocculant( MBF) is a kind of novel flocculant,which is widely used for the food industry,highly concentrated organic waste water treatment and the urban water supply technology. Due to its characteristics of superior flocculation effect,without secondary pollution to the environment and being easily degraded,MBF has been emerging as a hotspot of water treatment research in recent years. In this paper,the latest progress of the preparation of MBFs and the flocculating mechanism were presented. The practical application research of MBFs for water treatment was reviewed. Finally,suggestions and development prospect of research on MBFs were discussed. | Zhou Xiaotie Han Zhao Sun Shiqun Zheng Zhixia Hai Zibin | 2015 | Meteorological and Environmental Research2015，6，10： | 3 |
| 3 | Noblemetal-free photocatalysts Mo S2-graphene/Cd S mixed nanoparticles/nanorods morphology with high visible light efficiency for H2evolution显示文摘 | Liu Miaomiao Li Fengyan Sun Zhixia | 2014 | Chemical Communications2014，50，11： | 1 |
| 4 | Trace metal sin traditional chinese medicine:a preliminary study using ICP-MS metal determination and Sa speciation显示文摘 | Wang xiaoru Zhang Zhixia Sun Dahai | 1999 | Atomic Spectroscopy1999，20，3： | 1 |
| 5 | Analysis and leaching characteristics of mercury and arsenic in Chinese medicinal material显示文摘 | Sun Daihai Zhuang Zhixia | 2002 | Analytica Chimica Acta2002，453，2： | 1 |
| 6 | Preparation of 20 (S)-protopanaxadiol PLGA Nanoparticles显示文摘[Objectives]To prepare 20(S)-protopanaxadiol PLGA nanoparticles(20(S)-PPD-PLGA-NPs).[Methods]20(S)-PPD-PLGA-NPs were prepared by emulsion solvent evaporation method,and the optimal formulation was screened by Box-Behnken experiment with particle size and drug loading as the indicators through single factor experiment,and the drug release in vitro was carried out.[Results]The average diameter of the nanoparticles was(119.60±2.29)nm and the polydispersity index was(0.12±0.02),the size was uniform.The encapsulation efficiency and drug loading of protopanaxadiol were(87.99±1.29)%and(14.86±0.25)%,respectively.[Conclusions]The 20(S)-PPD-PLGA-NPs were successfully prepared by emulsion solvent evaporation method,and the 20(S)-PPD-PLGA-NPs had good stability,to lay a foundation for the study of 20(S)-PPD-PLGA-NPs in vitro and in vivo. | Tao PAN Baifang GONG Zhixia WANG Hanyu SUN Xuanle YIN | 2024 | Medicinal Plant2024，15，1： | 0 |
| 7 | Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults,especially in obese individuals:a prospective cohort study显示文摘Background:Mushrooms are a good source of many nutrients which are potentially beneficial for chronic diseases.We speculated that due to its abundant nutrients edible mushrooms might have a beneficial effect on the prevention of subclinical thyroid dysfunction(SCTD).Therefore,we designed a large-scale cohort study to examine whether mushrooms consumption is a protective factor for SCTD in adults.Methods:This prospective cohort study investigated 6631 participants(mean age:(45.0±10.2)years;55.1%men).Edible mushrooms consumption was measured at baseline using a validated food frequency questionnaire.SCTD was defined as abnormal serum thyroid-stimulating hormone levels and normal free thyroxine.Cox proportional hazards regression models were used to examine the association of edible mushrooms consumption with incident SCTD.Results:During follow-up period,a total of 262 new cases of SCTD were identified,the incidence rate of subclinical hypothyroidism was 8.9/1000 person-years and subclinical hyperthyroidism was 7.2/1000 person-years.After adjusting potential confounding factors,the multivariable hazard ratios(95%confidence intervals)for subclinical hypothyroidism were 1.00(reference)for almost never,0.53(0.29,0.97)for 1-3 times/week and 0.30(0.10,0.87)for≥4 times/week(P for trend=0.02).It also showed edible mushrooms consumption was inversely associated with subclinical hypothyroidism in obese individuals but not non-obese individuals,the final hazard ratios(95%confidence intervals)were 0.14(0.03,0.73)(P for trend<0.01).Conclusions:This population-based prospective cohort study has firstly demonstrated that higher edible mushrooms consumption was significantly associated with lower incidence of subclinical hypothyroidism among general adult population,especially in obese individuals. | Juanjuan Zhang Sabina Rayamajhi Amrish Thapa Ge Meng Qing Zhang Li Liu Hongmei Wu Yeqing Gu Shunming Zhang Tingjing Zhang Xuena Wang Zhixia Cao Jun Dong Xiaoxi Zheng Xu Zhang Xinrong Dong Xing Wang Shaomei Sun Ming Zhou Qiyu Jia Kun Song Kaijun Niu | 2023 | Food Science and Human Wellness2023，12，1： | 0 |
| 8 | Multi-Dimensional Composite Frame as Bifunctional Catalytic Medium for Ultra-Fast Charging Lithium-Sulfur Battery显示文摘The shuttle effect of soluble lithium polysulfides(LiPSs)between electrodes and slow reaction kinetics lead to extreme inefficiency and poor high current cycling stability,which limits the commercial application of Li-S batteries.Herein,the multi-dimensional composite frame has been proposed as the modified separator(MCCoS/PP)of Li-S battery,which is composed of CoS_(2) nanoparticles on alkali-treated MXene nanosheets and carbon nanotubes.Both experiments and theoretical calculations show that bifunctional catalytic activity can be achieved on the MCCoS/PP separator.It can not only promote the liquid-solid conversion in the reduction process,but also accelerate the decomposition of insoluble Li_(2)S in the oxidation process.In addition,LiPSs shuttle effect has been inhibited without a decrease in lithium-ion transference numbers.Simultaneously,the MCCoS/PP separator with good LiPSs adsorption capability arouses redistribution and fixing of active substances,which is also beneficial to the rate performance and cycling stability.The Li-S batteries with the MCCoS/PP separator have a specific capacity of 368.6 mAh g^(−1) at 20C,and the capacity decay per cycle is only 0.033%in 1000 cycles at 7C.Also,high area capacity(6.34 mAh cm^(−2))with a high sulfur loading(7.7 mg cm^(−2))and a low electrolyte/sulfur ratio(7.5μL mg^(−1))is achieved. | Shuhao Tian Qi Zeng Guo Liu Juanjuan Huang Xiao Sun Di Wang Hongcen Yang Zhe Liu Xichao Mo Zhixia Wang Kun Tao Shanglong Peng | 2022 | Nano-Micro Letters2022，14，12： | 0 |
| 9 | In Vitro Nanobody Library Construction by Using Gene Designated-Region Pan-Editing Technology显示文摘Camelid single-domain antibody fragments(nanobodies)are an emerging force in therapeutic biopharmaceuticals and clinical diagnostic reagents in recent years.Nearly all nanobodies available to date have been obtained by animal immunization,a bottleneck restricting the large-scale application of nanobodies.In this study,we developed three kinds of gene designatedregion pan-editing(GDP)technologies to introduce multiple mutations in complementarity-determining regions(CDRs)of nanobodies in vitro.Including the integration of G-quadruplex fragments in CDRs,which induces the spontaneous multiple mutations in CDRs;however,these mutant sequences are highly similar,resulting in a lack of sequences diversity in the CDRs.We also used CDR-targeting traditional gRNA-guided base-editors,which effectively diversify the CDRs.And most importantly,we developed the self-assembling gRNAs,which are generated by reprogrammed tracrRNA hijacking of endogenous mRNAs as crRNAs.Using base-editors guided by self-assembling gRNAs,we can realize the iteratively diversify the CDRs.And we believe the last GDP technology is highly promising in immunization-free nanobody library construction,and the full development of this novel nanobody discovery platform can realize the synthetic evolution of nanobodies in vitro. | Zhiyuan Niu Zhixia Luo Pengyang Sun Linwei Ning Xinru Jin Guanxu Chen Changjiang Guo Lingtong Zhi Wei Chang Wuling Zhu | 2022 | BioDesign Research2022，，1： | 0 |
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