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| 1 | Role of circulating microRNAs in liver diseases显示文摘MicroRNAs(miRNAs) are small RNAs regulate gene expression by inhibiting the turnover of their target mRNAs. In the last years, it became apparent that miRNAs are released into the circulation and circulating miRNAs emerged as a new class of biomarkers for various diseases. In this review we summarize available data on the role of circulating miRNAs in the context of acute and chronic liver diseases including hepatocellular and cholangiocellular carcinoma. Data from animal models are compared to human data and current challenges in the field of miRNAs research are discussed. | Sven H Loosen Florian Schueller Christian Trautwein Sanchari Roy Christoph Roderburg | 2017 | World Journal of Hepatology2017，9，12： | 7 |
| 2 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 3 | Right Portal Vein Ligation Combined With In Situ Splitting Induces Rapid Left Lateral Liver Lobe Hypertrophy Enabling 2-Staged Extended Right Hepatic Resection in Small-for-Size Settings显示文摘 | Andreas A. Schnitzbauer Sven A. Lang Holger Goessmann Silvio Nadalin Janine Baumgart Stefan A. Farkas Stefan Fichtner-Feigl Thomas Lorf Armin Goralcyk Rüdiger H?rbelt Alexander Kroemer Martin Loss Petra Rümmele Marcus N. Scherer Winfried Padberg Alfred K? | 2012 | Annals of Surgery2012，，3： | 2 |
| 4 | Emission from quantum-dot high-β microcavities: transition from spontaneous emission to lasing and the effects of superradiant emitter coupling显示文摘Measured and calculated results are presented for the emission properties of a new class of emitters operating in the cavity quantum electrodynamics regime.The structures are based on high-finesse GaAs/AlAs micropillar cavities,each with an active medium consisting of a layer of InGaAs quantum dots(QDs)and the distinguishing feature of having a substantial fraction of spontaneous emission channeled into one cavity mode(highβ-factor).This paper demonstrates that the usual criterion for lasing with a conventional(lowβ-factor)cavity,that is,a sharp non-linearity in the input–output curve accompanied by noticeable linewidth narrowing,has to be reinforced by the equal-time second-order photon autocorrelation function to confirm lasing.The paper also shows that the equal-time second-order photon autocorrelation function is useful for recognizing superradiance,a manifestation of the correlations possible in high-βmicrocavities operating with QDs.In terms of consolidating the collected data and identifying the physics underlying laser action,both theory and experiment suggest a sole dependence on intracavity photon number.Evidence for this assertion comes from all our measured and calculated data on emission coherence and fluctuation,for devices ranging from light-emitting diodes(LEDs)and cavity-enhanced LEDs to lasers,lying on the same two curves:one for linewidth narrowing versus intracavity photon number and the other for g(2)(0)versus intracavity photon number. | Sören Kreinberg Weng W Chow Janik Wolters Christian Schneider Christopher Gies Frank Jahnke Sven Höfling Martin Kamp Stephan Reitzenstein 无 | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 5 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 6 | MALAT1 — a paradigm for long noncoding RNA function in cancer显示文摘 | Tony Gutschner Monika H?mmerle Sven Diederichs | 2013 | Journal of Molecular Medicine2013，，7： | 2 |
| 7 | The role of market orientation and entrepreneurial orientation for new production development performance in manufacturing firms显示文摘 | JOHAN F SVEN A H | 2007 | Technology Analysis&Strategic Management2007，，11： | 1 |
| 8 | New developments in the diagnosis of bloodstream infections显示文摘 | Remco P H Peters Michiel A van Agtmael Sven A Danner | 2004 | Infectious Diseases2004，4，12： | 1 |
| 9 | Early results of a single-blinded, randomized, controlled, Internet-based multicenter trial comparing Prolene and Vypro?II mesh in Lichtenstein hernioplasty显示文摘 | Sven Bringman Timo-Jaakko Heikkinen Staffan Wollert Johanna ?sterberg Sam Smedberg H?kan Granlund Stig Ramel G?ran Fell?nder Bo Anderberg | 2004 | Hernia2004，，2： | 1 |
| 10 | Mercury emission control in coal-fired plants: The role of wet scrubbers显示文摘 | Mercedes D S Sven U Klaus R G H | 2007 | Fuel Processing Technology2007，88，3： | 1 |
| 11 | C~ompact, High Efficiency, Passively Q-switched Nd: YAG MOPA for Spaceborne Laser-altimetry 显示文摘 | SVEN H RAFAEL H JOERG N | 2006 | Solid State Lasers2006，6100，： | 1 |
| 12 | Intrasseous ultrasound in the placement of pedicle screws in the lumbar spine显示文摘 | Sven R Kantelhardt MD Christoph H | 2009 | Spine2009，4，40： | 1 |
| 13 | Effectiveness and side effects of closed and open suctioning: an experimental evaluation显示文摘 | Sophie Lindgren Birgitta Almgren Marieann H?gman Sven Lethvall Erik Houltz Stefan Lundin Ola Stenqvist | 2004 | Intensive Care Medicine2004，，8： | 1 |
| 14 | Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin显示文摘 | Volkhard Jenning Anja Gysler Monika Sch?fer-Korting Sven H Gohla | 2000 | European Journal of Pharmaceutics and Biopharmaceutics2000，，3： | 1 |
| 15 | Service screening with mammography of women aged 70–74 years in Sweden显示文摘 | H?kan Jonsson Sven T?rnberg Lennarth Nystr?m Per Lenner | 2003 | Cancer Detection and Prevention2003，，5： | 1 |
| 16 | Apoptosis induced by ischemia and reperfusion in experimental lung transplantation显示文摘 | Uz S Ariana G Sven H | 2000 | Ann Thorac Surg2000，69，5： | 1 |
| 17 | Shallow drilling of seafloor hydrothermal systems using the BGS rockdrill 显示文摘 | Sven P Peter M H Thomas K | 2005 | Marine Georesources and Geotechnology2005，，23： | 1 |
| 18 | Ecosystem services in urban areas显示文摘 | PER B SVEN H | 1999 | Ecological economics1999，29，2： | 1 |
| 19 | Malignancy and stroke显示文摘 | Sven H Philippe L | 2005 | Seminars in Cerebrovascular Diseases and Stroke2005，5，1： | 1 |
| 20 | Nerve growth factor and its precursor differentially regulate hair cycle progression in mice 显示文摘 | Eva M J Sven H Greta G | 2006 | J Histoehem Cytochem2006，54，3： | 1 |
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