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| 1 | nsights into molecular therapy of glioma: current .-hallenges and next generation blueprint显示文摘Glioma 说明人的大脑肿瘤的多数。与占优势的治疗政体,病人有差的幸存率。尽管有在主流的 glioma 治疗的当前的开发,为 glioma 的痊愈看起来从活动范围。glioma 和获得的电阻的渗透性的性质 substancially 限制治疗学的选择。glioma 和 proteogenomic 描述的复杂 pathobiology 的更好的说明可能最后为更复杂、有效的联合政体的设计打开新奇大街。这能被个别地定制进步 neuroimaging 技术完成,终止有 激活prodrug 基因的 DNA 合成, silencing gliomagenesis 基因(基因治疗),指向的 miRNA oncogenic 活动( miRNA-mRNA 相互作用),有干细胞治疗的联合 Hedgehog-Gli/Akt 禁止者,作为抗原采用肿瘤 lysates 由细胞毒素的 T 淋巴细胞(树枝状的房间种痘)为肿瘤特定的癌症干细胞的有效弄空采购原料,妄想的反的采纳转移因此,现在的评论捕获与分子的机制象外科,放射和化疗的限制一样在 glial tumorigenesis 包含了联系的最近的趋势。在这篇文章,我们极其也讨论下一代为 glioma 的成功的治疗的分子的治疗学的策略和他们的机制。 | Y RAJESH Ipsita PAL Payel BANIK Sandipan CHAKRABORTY Sachin A BORKAR Goutam DEY Ahona MUKHERJEE Mahitosh MANDAL | 2017 | Acta Pharmacologica Sinica2017，38，5： | 16 |
| 2 | Direct characterization of a nonlinear photonic circuit’s wave function with laser light显示文摘Integrated photonics is a leading platform for quantum technologies including nonclassical state generation1–4,demonstration of quantum computational complexity5 and secure quantum communications6.As photonic circuits grow in complexity,full quantum tomography becomes impractical,and therefore an efficient method for their characterization7,8 is essential.Here we propose and demonstrate a fast,reliable method for reconstructing the two-photon state produced by an arbitrary quadratically nonlinear optical circuit.By establishing a rigorous correspondence between the generated quantum state and classical sum-frequency generation measurements from laser light,we overcome the limitations of previous approaches for lossy multimode devices9,10.We applied this protocol to a multi-channel nonlinear waveguide network and measured a 99.28±0.31%fidelity between classical and quantum characterization.This technique enables fast and precise evaluation of nonlinear quantum photonic networks,a crucial step towards complex,largescale,device production. | Francesco Lenzini Alexander N Poddubny James Titchener Paul Fisher Andreas Boes Sachin Kasture Ben Haylock Matteo Villa Arnan Mitchell Alexander S Solntsev Andrey A Sukhorukov Mirko Lobino | 2018 | Light(Science & Applications)2018，7，1： | 2 |
| 3 | In vitro antioxidant and antimicrobial activity cycloart-23-ene-3β,25-diol(B2) isolated from Pongamia pinnata(L.Pierre)显示文摘Objective:To evaluate the in-vitro antioxidant and antimicrobial activity of cvcloart-23- ene-3β,25-diol(called as B2) isolated from stem bark of Pongamia pinnata.Methods:In vitro antioxidant activity of B2 was determined by methods for determination of Dl’PH radical scavenging,reducing power,superoxide anion radical scavenging,hydroxyl radical scavenging, hydrogen peroxide scavenging,metal chelating and nitric oxide radical scavenging at the doses of 20.40.60.80 and 100μg/mL,respectively.3 -tocopherol with same concentration was used as a standard antioxidant.In vitro antimicrobial activity of B2 was determined by cup plate method in different concentration range of 10-100μg/mL.Results:The results indicated that dose dependent%reduction against DPPH radical,reducing power,superoxide anion radical scavenging,hydroxyl radical scavenging,metal chelating,hydrogen peroxide scavenging and nitric oxide radical scavenging by B2 andβ-tocopherol.Conclusions:It is concluded that cycloart 23-ene-3β,25 diol(B2) showed dose dependent antioxidant activity.B2 showed more DPPH radical scavenging,reducing power,superoxide scavenging,hydroxyl radical scavenging, metal chelating scavenging,hydrogen peroxide radical scavenging and nitric oxide radical scavenging activity thanβ-tocopherol and in case of antimicrobial activity B2 exhibited broad-spectrum activ ity against bacteria and strong activity against yeast type of fungi. | Sachin L Badole Anand A Zanwar Abhijeet N Khopade Subhash L Bodhankar | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 2 |
| 4 | Underhood thermal simulation of a small passenger vehicle with rear engine compartment to evaluate and enhance radiator performance显示文摘 | Vivek K Sachin A S | 2010 | SAE International2010，，： | 1 |
| 5 | Polynitroaniline as brightener for zinc - nickel alloy plating from noncyanide sulphate bath 显示文摘 | Sachin H P Achary G Naik Y A | 2007 | Bull Mater Sci2007，30，2： | 1 |
| 6 | Reduction in post-prandial hyperglycemic excursion through o-glucosidase inhibition by 显示文摘 | ASHOK K T RAVINDRA M K SACHIN B A | 2008 | Bioorg Med Chem Lett2008，18，14： | 1 |
| 7 | Effect of prior corrosion on short crack behavior in 2024-T3 aluminum alloy 显示文摘 | Kimberii J A Sachin R S Paul N C | 2008 | Corrosion Science2008，50，9： | 1 |
| 8 | Deoximation using Dess-Martin periodinane: regeneration of ketones from ketoximes 显示文摘 | Sachin S C Krishnacharya G A | 1998 | Tetrahedron Lett1998，39，20： | 1 |
| 9 | A mile, chemoselective, oxidative method for deoximation using Dess-Martin periodinane 显示文摘 | Sachin S C Krishnacharya G A | 1999 | Synthesis1999，，5： | 1 |
| 10 | Does local endometrialinjury in the nontransfer cycle improve the IVF-ET outcome in the subsequentcycle in patients with previous unsuccessful IVF? A randomized controlled pilotstudy显示文摘 | Sachin A Narvekar Neelima Gupta Nivedita Shetty | | 0，，01： | 1 |
| 11 | Optimization of microwave, ultra-sonic and supercritical carbon dioxide assisted extraction techniques for curcumin from Curcuma longa显示文摘 | Wakte P S Sachin B S Patil A A | 2011 | Separation and Purification Technology2011，79，： | 1 |
| 12 | Optimization of microwave, ultra-sonic and supercritical carbon dioxide assisted extraction techniques for curcumin from Curcuma longa显示文摘 | Wakte P S Sachin B S Patil A A | 2011 | Separation and Purification Technology2011，79，： | 1 |
| 13 | The role of surface acidity in adsorption of aromatic sulfur heterocycles from fuels显示文摘 | Sachin N A H M S H Bruce J T | 2013 | Fuel2013，105，56： | 1 |
| 14 | Effect of molecular weight heterogeneity on drug encapsulation efficiency of gelatin nano-particles显示文摘 | Saxena A Sachin K Bohidar HB | 2005 | Colloids Surf B Biointerfaces2005，45，1： | 1 |
| 15 | Facile Conversion of Acyldiithiocarbazinate Salts to 1,3,4-Oxadiazole Derivatives Under Microwave Irradiation 显示文摘 | Sachin J Karnik A V | 2002 | Synth Commun2002，32，1： | 1 |
| 16 | Satellite derived trends in NO 2 over the major global hotspot regions during the past decade and their inter-comparison显示文摘 | Sachin D. Ghude R.J. Van der A G. Beig S. Fadnavis S.D. Polade | 2009 | Environmental Pollution2009，，6： | 1 |
| 17 | Rapid and egicient synthesis of symmetrical alkyl disulfides under phase transfer conditions显示文摘 | Sachin U S Mandan C Josph A | 2007 | Tetrahedron Letters2007，48，： | 1 |
| 18 | Supplier Development: Improving Supplier performance through Knowledge Transfer显示文摘 | Sachin B Vincent A M | 2007 | Journal of Operations Management2007，，25： | 1 |
| 19 | Cited2Modulates Hypoxia-In-ducible Factor-Dependent Expression of Vascular Endothelial Growth Factor in Nucleus Pulposus Cells of the Rat Intervertebral Disc显示文摘 | Amit A Sachin G Makarand VR | 2008 | Arthritis rheumatism2008，58，12： | 1 |
| 20 | A ratiometric fluorescent On-Off Zn2+chemosensor on a tripropargylamine pyrene azide click adduct 显示文摘 | Sachin A Ingale Frank Seela | 2012 | J Org Chem2012，77，： | 1 |
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