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| 1 | Activity and bioavailability of tepotinib for leptomeningeal metastasis of NSCLC with MET exon 14 skipping mutation显示文摘Tepotinib is a key drug for cancer patients with mesenchymal-epithelial transition receptor tyrosine kinase proto-oncogene(MET)exon 14 skipping mutation.However,its bioavailability in the cerebrospinal fluid(CSF)in humans has not been fully elucidated.Moreover,information about the efficacy of tepotinib in patients with leptomeningeal metastasis is limited.Here,we present the case of a 56-year-old man who was diagnosed with lung adenocarcinoma with MET exon 14 skipping mutation.He was urgently hospitalized due to leptomeningeal metastasis.We administered tepotinib 500 mg/day as the second-line therapy and observed improvement in leptomeningeal metastasis and performance status.The tepotinib concentrations reached 1,648 ng/mL in the plasma and 30.6 ng/mL in the CSF,with a penetration rate(CSF/plasma)of 1.83%.These demonstrate tepotinib could achieve a high rate of central nervous system transition and could be effective against leptomeningeal metastasis. | Hisashi Tanaka Kageaki Taima Tomonori Makiguchi Junichi Nakagawa Takenori Niioka Sadatomo Tasaka | 2021 | Cancer Communications2021，41，1： | 4 |
| 2 | Hepatic portal venous gas after endoscopy in a patient with anastomotic obstruction显示文摘A 72-year-old male underwent a laparoscopic low anterior resection for advanced rectal cancer.A diverting loop ileostomy was constructed due to an anastomotic leak five days postoperatively.Nine months later,colonoscopy performed through the stoma showed complete anastomotic obstruction.The mucosa of the proximal sigmoid colon was atrophic and whitish.Ten days after the colonoscopy,the patient presented in shock with abdominal pain.Abdominal computed tomography scan showed hepatic portal venous gas(HPVG) and a dilated left colon.HPVG induced by obstructive colitis was diagnosed and a transverse colostomy performed emergently.His subsequent hospital course was unremarkable.Rectal anastomosis with diverting ileostomy is often performed in patients with low rectal cancers.In patients with anastomotic obstruction or severe stenosis,colonoscopy through diverting stoma should be avoided.Emergent operation to decompress the obstructed proximal colon is necessary in patients with a blind intestinal loop accompanied by HPVG. | Ai Sadatomo Koji Koinuma Rihito Kanamaru Yasuyuki Miyakura Hisanaga Horie Alan T Lefor Yoshikazu Yasuda | 2015 | World Journal of Gastrointestinal Surgery2015，7，2： | 2 |
| 3 | New approach for the treatment of medulloblastoma by transfection with glial fibrillary acidic protein gene显示文摘 | Sadatomo T Yoshida J Wakabayashi T | 1996 | Surg Oncol1996，5，2： | 1 |
| 4 | Transformation of human glioma cell lines with p16 gene inhibits cell proliferation 显示文摘 | HAMA S SADATOMO T YOSHIOKA H | 1997 | Anticancer Res1997，17，3： | 1 |
| 5 | Growth inhibition of human glioma cells by transfextion-induced p21 and its effects on telomerase activity显示文摘 | Harada K Kurisu K Sadatomo T | 2000 | Neurooncology2000，47，1： | 1 |
| 6 | Evaluation of relation among aneurismal neck, parent artery, and daughter arteries in middle cerebral artery aneurysms, by three-dimensional digital subtraction angiography 显示文摘 | SADATOMO T YUKI K MIGITA K | 2005 | Neurosurg Rev2005，28，3： | 1 |
| 7 | Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung显示文摘 | Mariko Kotani Toru Kotani Akitoshi Ishizaka Seitaro Fujishima Hidefumi Koh Sadatomo Tasaka Makoto Sawafuji Eiji Ikeda Kiyoshi Moriyama Yoshifumi Kotake Hiroshi Morisaki Naoki Aikawa Akira Ohashi Kouji Matsushima Yuh-Chin T. Huang Junzo Takeda | 2004 | Critical Care Medicine2004，，2： | 1 |
| 8 | Morphological differences between ruptured and unruptured cases in middle cerebral arteryaneurysms显示文摘 | Sadatomo T Yuki K Migita K | | 0，，03： | 1 |
| 9 | Pharmacology of Acute Lung Injury显示文摘 | Sadatomo Tasaka Naoki Hasegawa Akitoshi Ishizaka | 2002 | Pulmonary Pharmacology & Therapeutics2002，，2： | 1 |
| 10 | Morphological differ-ences between ruptured and unruptured cases in middle cere-bral artery aneurysms 显示文摘 | Sadatomo T Yuki K Migita K | 2008 | Neurosurgery2008，62，： | 1 |
| 11 | Pharmacology of acute lung injury显示文摘 | Sadatomo T Naki H Akitoshi I | 2002 | Pulmon Pharmacol Ther2002，15，： | 1 |
| 12 | New approach for the treatment of med alloblastoma by transferction with glial fibrillary acicic protein gene 显示文摘 | Sadatomo T Yoshida J Wakabayashi T | 1996 | Surg Oncol1996，5，2： | 1 |
| 13 | Transformation of human glioma cell lines with the p16 gene inhibits cell proliferation显示文摘 | ama S Sadatomo T Yoshioka H | 1997 | Anticancer Res1997，17，3： | 1 |
| 14 | Morphological differences between ruptured and unruptured cases in middle cerebral ar- tery aneurysms 显示文摘 | Sadatomo T Yuki K Migita K | 2008 | Neurosargery2008，62，3： | 1 |
| 15 | A case of metachronous gastrointestinal perforation of a patient with metastatic rectal cancer during treatment with bevacizumab-based chemotherapy 显示文摘 | Sadatomo A Koinuma K Miki A | 2013 | Gan to Kagaku Ryoho2013，40，7： | 1 |
| 16 | Morphological differences be- tween ruptured and unruptured cases in middle cerebral artery aneurysms 显示文摘 | Sadatomo T Yuki K Migita K | 2008 | Neurosurgery2008，1，3： | 1 |
| 17 | Evaluation of relation among aneurysmal neck,parent artery,and daughter arteries in middle cerebral artery aneurysms,by three-dimensional digital subtraction angiography显示文摘 | Sadatomo T Yuki K Migita K | 2005 | Neurosurg Rev2005，28，3： | 1 |
| 18 | Morphological diffe- rences between ruptured and unruptured cases in middle cerebral artery aneurysms 显示文摘 | Sadatomo T Yuki K Migita K | 2008 | Neurosurge''2008，62，3： | 1 |
| 19 | Morphological differences between ruptured and unruptured cases in middle cerebral artery aneurysms显示文摘 | Sadatomo T Yuki K Migita K | | 0，，3： | 1 |
| 20 | Growth inhibition of human glioma cells by transfection-induced P21 and its effects on telomerase activity显示文摘 | Harada K Kurisu K Sadatomo T | 2000 | J Neurooncol2000，47，1： | 1 |
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