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| 1 | Macrophages are the primary effector cells in IL-7-induced arthritis显示文摘Synovial macrophages are crucial in the development of joint inflammation and bone damage;however, the pathways that controlmacrophage remodeling in inflammatory M1 cells or bone-eroding osteoclasts are not fully understood. We determined thatelevated IL-7R/CD127 expression is the hallmark of rheumatoid arthritis (RA) M1 macrophages and that these cells are highlyresponsive to interleukin-7 (IL-7)-driven osteoclastogenesis. We established that lipopolysaccharide (LPS), interferon-γ (IFNγ), andtumor necrosis factor-α (TNFα), the classic M1 macrophage mediators, enhance IL-7R expression in RA and murine macrophages.The local expression of IL-7 provokes arthritis, predominantly through escalating the number of F480^(+)iNOS^(+) cells rather than CD3^(+)T cells. Ectopic LPS injection stabilizes IL-7-induced arthritis by increasing myeloid IL-7R expression, in part via IFNγ induction.Hence, in RAG−/− mice, IL-7-mediated arthritis is suppressed because of the reduction in myeloid IL-7R expression due to the lackof IFNγ. Moreover, the amelioration of IL-7-induced arthritis by anti-TNF therapy is due to a decrease in the number of cells in theunique F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) subset, with no impact on the F480^(+)Arginase^(+) cell or CD3^(+) T cell frequency. Consistent with thepreclinical findings, the findings of a phase 4 study performed with RA patients following 6 months of anti-TNF therapy revealedthat IL-7R expression was reduced without affecting the levels of IL-7. This study shifts the paradigm by discovering that IL-7-induced arthritis is dependent on F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) cell function, which activates TH-1 cells to amplify myeloid IL-7Rexpression and disease severity. | Seung-jae Kim Huan J.Chang Michael VVolin Sadiq Umar Katrien Van Raemdonck Aimee Chevalier Karol Palasiewicz John W.Christman Suncica Volkov Shiva Arami Mehrdad Maz Anjali Mehta Ryan K.Zomorrodi David A.Fox Nadera Sweiss Shiva Shahrara | 2020 | Cellular & Molecular Immunology2020，17，7： | 4 |
| 2 | Evaluation of five medicinal plants used in diarrhoea treatment in Nigeria显示文摘 | Abdulkarim Agunu Sadiq Yusuf Gabriel Onyiloyi Andrew Abdulkadir Umar Zezi Ezzeldin Mukhtar Abdurahman | 2005 | Journal of Ethnopharmacology2005，，1： | 2 |
| 3 | IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion显示文摘Flares of joint inflammation and resistance to currently available biologic therapeutics in rheumatoid arthritis(RA)patients could reflect activation of innate immune mechanisms.Herein,we show that a TLR7 GU-rich endogenous ligand,miR-Let7b,potentiates synovitis by amplifying RA monocyte and fibroblast(FLS)trafficking.miR-Let7b ligation to TLR7 in macrophages(MΦs)and FLSs expanded the synovial inflammatory response.Moreover,secretion of M1 monokines triggered by miR-Let7b enhanced Th1/Th17 cell differentiation.We showed that IRAK4 inhibitor(i)therapy attenuated RA disease activity by blocking TLR7-induced M1 MΦor FLS activation,as well as monokine-modulated Th1/Th17 cell polarization.IRAK4i therapy also disrupted RA osteoclastogenesis,which was amplified by miR-Let7b ligation to joint myeloid TLR7.Hence,the effectiveness of IRAK4i was compared with that of a TNF inhibitor(i)or anti-IL-6R treatment in collagen-induced arthritis(CIA)and miR-Let7b-mediated arthritis.We found that TNF or IL-6R blocking therapies mitigated CIA by reducing the infiltration of joint F480+iNOS+MΦs,the expression of certain monokines,and Th1 cell differentiation.Unexpectedly,these biologic therapies were unable to alleviate miR-Let7b-induced arthritis.The superior efficacy of IRAK4i over anti-TNF or anti-IL-6R therapy in miR-Let7b-induced arthritis or CIA was due to the ability of IRAK4i therapy to restrain the migration of joint F480+iNOS+MΦs,vimentin+fibroblasts,and CD3+T cells,in addition to negating the expression of a wide range of monokines,including IL-12,MIP2,and IRF5 and Th1/Th17 lymphokines.In conclusion,IRAK4i therapy may provide a promising strategy for RA therapy by disconnecting critical links between inflammatory joint cells. | Sadiq Umar Karol Palasiewicz Katrien Van Raemdonck Michael V.Volin Bianca Romay MAsif Amin Ryan K.Zomorrodi Shiva Arami Mark Gonzalez Vikram Rao Brian Zanotti David A.Fox Nadera Sweiss Shiva Shahrara | 2021 | Cellular & Molecular Immunology2021，18，9： | 1 |
| 4 | Hippocampal neurodegeneration in experimental autoimmune encephalomyelitis (EAE): potential role of inflammation activated myeloperoxidase显示文摘 | Mir Sajad Jamil Zargan Raman Chawla Sadiq Umar Mir Sadaqat Haider A. Khan | 2009 | Molecular and Cellular Biochemistry (-)2009，，1： | 1 |
| 5 | Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats显示文摘 | Sadiq Umar Jamil Zargan Khalid Umar Sayeed Ahmad Chandra Kant Katiyar Haider A. Khan | 2012 | Chemico-Biological Interactions2012，，1： | 1 |
| 6 | Synthesis, characterization, antiamoebic activity and cytotoxicity of novel series of pyrazoline derivatives bearing quinoline tail显示文摘 | Aisal Hayat Attar Salahuddin Sadiq Umar | 2010 | European Journal of Medicinal Chemistry2010，45，10： | 1 |
| 7 | β-Islet cell regeneration potential of Mirabilis jalapa in hyperglycemic rats显示文摘Objective:To investigate the role of Mirabilis jalapa root extracts in restoration of glucose homeostasis in alloxan-induced hyperglycemic Wistar albino rats.Methods:Experimental hyperglycemic rats were treated daily with 200 and 400 mg/kg of Mirabilis jalapa extracts after initial fasting for 6 h.Two-hour postprandial glucose and changes in body weight were monitored during treatment.After 14 d,the rats were sacrificed and blood was collected for biochemical assessment of serum glucose and insulin levels,lipid profile,and oxidative stress markers.Histopathological examinations of harvested pancreas were also carried out.Results:Mirabilis jalapa root extracts at 200 and 400 mg/kg increased the body weight of hyperglycemic rats.Postprandial glucose levels of the extract-treated hyperglycemic groups progressively declined during treatment compared with the untreated hyperglycemic control group(P<0.05).The lipid profile indices of the untreated negative control group were significantly elevated(P<0.05),which were reversed by treatment with Mirabilis jalapa extracts.The remarkable increases in antioxidant enzyme activities and a significant decrease in malondialdehyde levels were observed in the hyperglycemic group treated with Mirabilis jalapa extracts.Mirabilis jalapa extracts also significantly increased serum insulin levels(P<0.05).In addition,histopathological examinations of the pancreas revealed a significant cell population within the islet nests of the extract-treated hyperglycemic groups.Conclusions:Mirabilis jalapa extract can restore glucose homeostasis and show hypoglycemic and hypolipidemic effects in hyperglycemic rats.Further studies are needed to verify the active components of the plant and the underlying mechanism of action in the future. | Masud Eneji Sadiq Chibuzo Egwuenu Rabiu Saidu Umar Wasagu Usman Zayyanu Umar Bello Usman | 2022 | Asian Pacific Journal of Tropical Biomedicine2022，12，8： | 0 |
| 8 | The Occurence of Gastrointestinal Helminths in Slaughtered Cattle in Azare, North-East Nigeria显示文摘A Cross-sectional Study was carried out to determine the prevalence of gastrointestinal(G.I.)helminths parasites in slaughtered cattle at Azare abattoir,Katagum Local Government Area,Bauchi State,North-Eastern Nigeria.One hundred and twenty faecal samples were examined using the floatation and sedimentation method.Out of the total samples tested,G.I.helminths infections were detected in 62 samples tested,giving an overall prevalence of 51.6%.Class nematodes are the most diverse class(56.5%),followed by trematodes(35.5%),while cestodes are the least prevalent(8.1%).There was a statistically significant difference in G.I.helminths’prevalence among different classes(p<0.05).Concerning sex and age,there was no statistically significant difference in the prevalence rate of G.I.helminths infection affecting the cattle(p>0.05).The Red Bororo breeds had the highest prevalence of 75%,while the least was recorded in White Fulani and Sokoto Gudali,40%each.There was a statistically significant difference in G.I helminth infection’s prevalence rate to breed(p<0.05).This study revealed that Fasciola spp.(15%)is the most prevalent G.I.helminths parasites detected,followed by Oesophagostomum spp(11.7%);Haemonchus spp.(9.2%);Strongyloides spp.(8.3%),Schistosoma spp.(3.3%);and Moniezia spp.(1.67%).Our findings from the present study revealed a high prevalence of G.I.helminths species affecting cattle in Azare,North-East Nigeria.Therefore,there is a great need for proper advocacy on appropriate management,regular deworming practices,and improved cattle hygiene to boost animal production.This will help in curbing significant loss to Nigeria’s economy and the world in general. | Musa Umar Bashir Mohammed Abubakar Haladu Ali Gagman Abubakar Sadiq Yusuf | 2021 | Journal of Zoological Research2021，3，1： | 0 |
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