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9篇 您的检索式:作者名="Safwat AS"
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1Molecular detection of monocyte chemotactic protein-1 polymorphism in spontaneous bacterial peritonitis patients显示文摘AIM: To investigate the association of the functional monocyte chemotactic protein-1(MCP-1) promoter polymorphism(A-2518G) with spontaneous bacterial peritonitis(SBP).METHODS: Fifty patients with post-hepatitis C liver cirrhosis and ascites were categorized into two groups; group Ⅰ included 25 patients with SBP and group Ⅱ included 25 patients free from SBP. In addition, a group of 20 healthy volunteers were included. We assessed the MCP-1 gene polymorphism and gene expression as well as interleukin(IL)-10 levels in both blood and ascitic fluid. RESULTS: A significant MCP-1 gene polymorphism was detected in groups Ⅰ and Ⅱ(P = 0.001 and 0.02 respectively). Group Ⅰ was associated with a significantly higher frequency of AG genotype [control 8(40%) vs SBP 19(76.0%), P < 0.001], and group Ⅱ was associated with a significantly higher frequency of GG genotype when compared to healthy volunteers [control 1(5%) vs cirrhotic 16(64%), P < 0.001]. Accordingly, the frequency of G allele was significantly higher in both groups(Ⅰ and Ⅱ) [control 10(25%) vs SBP 27(54%), P < 0.001 and vs cirrhotic 37(74.0%), P < 0.001, respectively]. The total blood and ascetic fluid levels of IL-10 and MCP-1 gene expression were significantly higher in group Ⅰ than in group Ⅱ. Group Ⅰ showed significant reductions in the levels of MCP-1 gene expression and IL-10 in the whole blood and ascetic fluid after therapy. CONCLUSION: MCP-1 GG genotype and G allele may predispose HCV infected patients to a more progressive disease course, while AG genotype may increase the susceptibility to SBP. Patients carrying these genotypes should be under supervision to prevent or restrict further complications.Maysa Kamal Salama Dina Sabry Mohamed AS Al-Ghussein Rasha Ahmed Sayed AbdAllah Fatma Mohamed Taha Wael Fathy Miriam Safwat Wadie Mona Nabih Amr Abul-Fotouh Tarneem Darwish 2014World Journal of Gastroenterology2014,20,33:7
2Pheochromocy toma in children and adolescents: a clinical spectrum显示文摘Bissada NK Safwat AS Seyam RM 2008J Pediatr Surg2008,43,3:1
3The clinical spectrum of phaeochromocytoma: analysis of 115 pa tients显示文摘Safwat AS Bissada NK Seyam RM 2008BJU Int2008,101,12:1
4Ureteroscopic holmium laser lithotripsy in patients with renal impairment显示文摘Safwat AS Bissada NK Kumar U 0,,01:1
5Experience with ureteroscopic holmium laser lithotripsy in children显示文摘Safwat AS Bissada NK Kumar U 2008Pediatr Surg Int2008,24,5:1
6Ureteroscopic holmium laser lithotripsy in patients with renal impairment 显示文摘Safwat AS Bissada NK Kumar U 2008Int Uroi Nephrol2008,40,1:1
7Pheochromocytoma of the urinary bladder显示文摘Safwat AS Bissada NK 2007Can J Urol2007,14,6:1
8Which type of ure- throplasty in failed hypospadias repair? An 8-year follow up 显示文摘Safwat AS Elderwy A Hammouda HM 2013J Pediatr Urol2013,9,6:1
9IYrculanem]s suprapubie stone extraction for posterior urethral stones in children: efficacy and sat?ty显示文摘Safwat AS Hameed DA Elgammal MA 2013Urology2013,82,:1
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