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| 1 | Effect of probiotics on pro-inflammatory cytokines and NF-κB activation in ulcerative colitis显示文摘AIM:To demonstrate the therapeutic effect of probiotics in patients with ulcerative colitis(UC),and their effect on inflammatory mediators and nuclear factor(NF)κB activation in these patients.METHODS:Thirty patients with mild to moderate UC were randomly classified into two groups:sulfasalazine group,who received sulfasalazine 2400 mg/d;and probiotic group,who received sulfasalazine 2400 mg/d with probiotic.The patients were investigated before and after 8 wk of treatment with probiotic(Lactobacillus delbruekii and Lactobacillus fermentum).Colonic activity of myeloperoxidase(MPO)was assayed with UV spectrophotometry,the colonic content of interleukin(IL)-6 was determined by enzyme-linked immunosorbent assay(ELISA),fecal calprotectin was determined by ELISA,and expression of NF-κB p65 and tumor necrosis factor (TNF)-αproteins in colonic tissue was identified by immunohistochemistry and reverse transcription polymerase chain reaction,respectively.RESULTS:At the start of the study,colonic mucosal injury and inflammation were demonstrated in UC patients by hematoxylin and eosin staining,and an increase in colonic MPO activity,fecal calprotectin,and expression of colonic TNF-αand NF-κB p65 proteins.The use of probiotic for 8 wk significantly ameliorated the inflammation by decreasing the colonic concentration of IL-6,expression of TNF-αand NF-κB p65,leukocyte recruitment,as demonstrated by a decrease in colonic MPO activity,and the level of fecal calprotectin compared to sulfasalazine group and the control group(P<0.05).CONCLUSION:Oral supplementation with probiotics could be helpful in maintaining remission and preventing relapse of UC. | Sahar K Hegazy Mohamed M El-Bedewy | 2010 | World Journal of Gastroenterology2010，16，33： | 44 |
| 2 | Orbital inflammatory disease:Pictorial review and differential diagnosis显示文摘Orbital inflammatory disease(OID) represents a collec tion of inflammatory conditions affecting the orbit. OID is a diagnosis of exclusion, with the differential diagno sis including infection, systemic inflammatory conditions and neoplasms, among other conditions. Inflammatory conditions in OID include dacryoadenitis, myositis, cel lulitis, optic perineuritis, periscleritis, orbital apicitis, and a focal mass. Sclerosing orbital inflammation is a rare condition with a chronic, indolent course involving dense fibrosis and lymphocytic infiltrate. Previously though to be along the spectrum of OID, it is now considered a distinct pathologic entity. Imaging plays an importan role in elucidating any underlying etiology behind orbita inflammation and is critical for ruling out other condi tions prior to a definitive diagnosis of OID. In this re view, we will explore the common sites of involvemen by OID and discuss differential diagnosis by site and key imaging findings for each condition. | Michael N Pakdaman Ali R Sepahdari Sahar M Elkhamary | 2014 | World Journal of Radiology2014，6，4： | 12 |
| 3 | Incidence and characteristics of HBV reactivation in hematological malignant patients in south Egypt显示文摘AIM:To investigate characteristics of hepatitis B virus(HBV)implicated in HBV reactivation in patients with hematological malignancies receiving immunosuppressive therapy.METHODS:Serum samples were collected from 53 patients with hematological malignancies negative for hepatitis B surface antigen(HBsAg)before the start of and throughout the chemotherapy course.HBV reactivation was diagnosed when the HBsAg status changed from negative to positive after the initiation of chemotherapy and/or when HBV DNA was detected by realtime detection polymerase chain reaction(RTD-PCR).For detecting the serological markers of HBV infection,HBsAg as well as antibodies to the core antigen(antiHBc)and to the surface antigen were measured in the sera by CEIA.Nucleic acids were extracted from sera,and HBV DNA sequences spanning the S gene were amplified by RTD-PCR.The extracted DNA was further subjected to PCR to amplify the complete genome as well as the specific genomic sequences bearing the enhancerⅡ/core promoter/pre-core/core regions(nt1628-2364).Amplicons were sequenced directly.RESULTS:Thirty-five(66%)of the 53 HBsAg-negative patients were found to be negative serologically for antiHBc,and the remaining 18(34%)patients were positive for anti-HBc.Five of the 53(9.4%)patients with hematologic malignancies experienced HBV reactivation.Genotype D1 was detected in all five patients.Four types of mutant strains were detected in the S gene product of HBV strains and were isolated from 3 patients with HBV reactivation:T/S120,L143,and I126.HBV DNA was detected in the pretreatment HBsAg-negative samples in one of the five patients with HBV reactivation.In this patient,sequences encompassing the HBV full genome obtained from sera before the start of chemotherapy and at the time of de novo HBV hepatitis were detected and it showed 100%homology.Furthermore,in the phylogenetic tree,the sequences were clustered together,thereby indicating that this patient developed reactivation from an occult HBV infection.CONCLUSION:Past infection with HBV is a risk factor for HBV reactivation in Egypt.Mandatory anti-HBc screening prior to chemotherapy in patients with hematological malignancies is recommended. | Abeer Elkady Sahar Aboulfotuh Elsayed Mostafa Ali Douaa Sayed Nashwa M Abdel-Aziz Amany M Ali Shuko Murakami Sayuki Iijima Yasuhito Tanaka | 2013 | World Journal of Gastroenterology2013，19，37： | 7 |
| 4 | Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt显示文摘AIM To investigate the prevalence and virological characteristics of occult hepatitis B virus(HBV) infections in patients with hematological malignancies in South Egypt.METHODS Serum samples were collected from 165 patients with hematological malignancies to monitor titers of HBV DNA, hepatitis B surface antigen(HBs Ag), and antibodies to HBV core(anti-HBc) and surface antigens. Serum samples negative for HBs Ag and positive for anti-HBc were subjected to nucleic acid extraction and HBV DNA detection by real-time polymerase chain reaction. DNA sequences spanning the S region were analyzed in cases with occult HBV infection. In vitro comparative study of constructed 1.24-fold wild type and S protein mutant HBV genotype D clones was further performed. RESULTS HBV DNA was detected in 23(42.6%) of 54 patients with hematological malignancies who were HBsA g negative, but anti-HBc positive, suggesting the presence of occult HBV infection. The complete HBV genome was retrieved from 6 occult HBV patients, and P120 T and S143 L were detected in 3 and 2 cases, respectively. Site directed mutagenesis was done to produce 1.24-fold genotype D clones with amino acid mutations T120 and L143. The in vitro analyses revealed that a lower level of extracellular HBsA g was detected by chemiluminescence enzyme immunoassay(CLEIA) with the clone containing T120 mutation, compared with the wild type or the clone with S143 L mutation despite the similar levels of extracellular and intracellular HBs Ag detected by Western blot. Southern blot experiments showed that the levels of intracellular HBV DNA were not different between these clones. CONCLUSION Occult HBV infection is common in patients with hematological malignancies and associated with P120 T and S143 L mutations. 120 T mutation impairs the detection of HBsA g by CLEIA. | Abeer Elkady Sayuki Iijima Sahar Aboulfotuh Elsayed Mostafa Ali Douaa Sayed Nashwa M Abdel-Aziz Amany M Ali Shuko Murakami Masanori Isogawa Yasuhito Tanaka | 2017 | World Journal of Hepatology2017，9，9： | 2 |
| 5 | A Randomized Trial Comparing Colloid Preload to Coload During Spinal Anesthesia for elective cesarean delivery显示文摘 | Sahar M Siddik-Sayyid Viviane G | 2009 | Ohstrtric Anesthrsiology2009，109，4： | 1 |
| 6 | Anti-VEGF therapy (bevacizumab) for sulfurmustard-induced comeal neovascularization associated withdelayed limbal stem cell deficiency in rabbits显示文摘 | KADAE T AMIR A COHEN L COHEN M SAHAR R GUT-MAN H | 2014 | Curr Eye2014，39，5： | 1 |
| 7 | Dietary flavonoids induce MLL translocations in primary human CD34^ + cells 显示文摘 | Sahar Barjesteh van Waalwijk van Doom - Khosrovani Janssen J Maas L M | 2007 | Carcinogenesis2007，28，8： | 1 |
| 8 | Single phase flow pressure drop and heat transfer in rectangular metallic microchannels 显示文摘 | SAHAR A M ZDEMIR M R FAYYADH E M | 2016 | Applied Thermal Engineering2016，93，： | 1 |
| 9 | Structural characteristic of Na《,2》O-P《,2》O《,5》-GeO《,2》 glass systems显示文摘 | SAHAR M R WAHAB A HUSSEIN A | 2007 | J Non Cryst Solids2007，353，1112： | 1 |
| 10 | Vasospasm due to massive subarachnoid haemorrhage - a rat model 显示文摘 | Ram Z Sahar A Hadani M | 1991 | Acta Neurochir( Wien)1991，110，34： | 1 |
| 11 | Flavonoids from Ephedra aphylla显示文摘 | Sahar A M H Heba H B Mahmoud A M N | 1997 | Phytochemistry1997，45，7： | 1 |
| 12 | Properties of SnO2-based ceramics 显示文摘 | Sahar M R | 1995 | Journal of Materials Sctence1995，30，： | 1 |
| 13 | 12-O-acetylphorbol-13-decanoate potently inhibitors cytopathic effects of human immunodeficiency virus typel (HIV-1) with activation of protein kinase 显示文摘 | SAHAR E M MESELHY R M NORIO N | 1999 | Chem Pharm Bull1999，47，9： | 1 |
| 14 | Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum显示文摘 | SAHAR E M MESALHY R M NORIO N | 1998 | Phytochemistry1998，49，6： | 1 |
| 15 | Improvement of familycarers' knowledge, skills and attitudes in caring for older people following the implementation of a Family Carers' Training Program in the community in Indonesia显示文摘 | Sahar J Courtney M Edwards H | 2003 | Int J Nurs Pract2003，9，4： | 1 |
| 16 | Diffusion as a toolof measuring temperature inside a capillary 显示文摘 | Michael U M Sahar J Victor O | 2008 | Analyt Chem2008，8，： | 1 |
| 17 | AngiotensinⅡenhances IL-18 mediated inflammatory gene expression in vascular smooth muscle cells:a novel cross-talk in the pathogenesis of atherosclerosis显示文摘 | Sahar S Dwarakanath R S Reddy M A | 2005 | Circ Res2005，96，10： | 1 |
| 18 | Regulation of monocyte chemoattractant protein-1 by the oxidized lipid, 13-hydroperoxyoctadecadienoic acid, in vascular smooth muscle cells via nuclear factor-kappa B (NF-kappa B) 显示文摘 | Dwarakanath R S Sahar S Reddy M A | 2004 | Journal of Molecular and Cellular Cardiology2004，36，4： | 1 |
| 19 | Silencing of chaperonin 21,that was differentially expressed in inflorescence of seedless and seeded grapes,promoted seed abortion in tobacco and tomato fruits 显示文摘 | Hanania U Velcheva M Or E Flaishman M Sahar N Perl A | 2007 | Transgenic Res2007，16，4： | 1 |
| 20 | Leaf phenolics of Punica Granaturn显示文摘 | Sahar A M Hussein Irmgard Merfort | 1994 | Phytochemistry1994，37，4： | 1 |
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