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| 1 | 乳汁免疫和猪流行性腹泻病毒病疫苗:历史和现状(译文)显示文摘由于肠道病毒感染导致仔猪在发病率、死亡率和生产能力丧失方面的影响,每年给养猪者带来数百万美元的损失。2013—2014年间,猪流行性腹泻病毒(PEDV)病的暴发给美国养猪业带来了9亿~18亿美元的经济损失。被动乳汁免疫被认为是保护新生哺乳仔猪免受PED等肠道疾病危害的最有希望和有效的方法。通过乳汁免疫被动保护哺乳仔猪的效果依赖于病原特异性IgA浆细胞转运至乳腺的数量和乳汁中分泌型IgA的积累程度,这种免疫途径被定义为'肠-乳腺-sIgA轴'。由于胎盘的不可穿透性,新生仔猪处于无免疫球蛋白的状态,对很多的传染性病原体极易感。它们仅依靠来源于母源的初乳和乳汁抗体获得被动保护。先前开发的关于猪传染性胃肠炎病毒(TGEV)病的活疫苗和灭活疫苗,提供了对母源性免疫和仔猪被动保护机制的理解。在这篇文章中,综述了猪传染性胃肠炎病毒诱导乳汁免疫的研究进展,并指出对当前养猪业正努力控制的猪流行性腹泻病毒感染和相关疫苗的研究方向。同时研究和鉴别出影响乳汁免疫和'肠-乳腺-sIgA轴'的各种因素,有助于改善妊娠母猪预防猪流行性腹泻病毒感染以及改进其它肠道病原用疫苗方案,从而达到提升整个猪群的免疫力、猪群健康和企业生产力的目的。 | Langel Stephanie N Paim Francine Chimelo Lager Kelly M Vlasova Anastasia N Saif Linda J 吕茂杰 | 2017 | 养猪2017，，1： | 3 |
| 2 | Rotavirus as a cause of diarrhea in pigs 显示文摘 | Bohl E H Kohler E M Saif L J | 1978 | J Am Vet Med Assoc1978，172，： | 1 |
| 3 | IGF system in cancer: from bench to clinic 显示文摘 | Chaves J Saif MW | 2011 | Anticancer Drags2011，22，3： | 1 |
| 4 | Rotavirus-like,cali-civirus-like,and 23-nm virus-like particles associated with diar-rhea in young pigs显示文摘 | SAIF L J BOHL E H THEIL K W | 1980 | J Clin Microbiol1980，12，1： | 1 |
| 5 | Coronavirus immunogens显示文摘 | SAIF L J | 1993 | Vet nicrobiol1993，37，34： | 1 |
| 6 | Molecular differentation of transmissible gastroenteritis virus and porcine respiratory coronavirus strains显示文摘 | Kwon H M Saif J | 1995 | Adv Exp Med Biol1995，380，： | 1 |
| 7 | Prevention of human rotavirus- induced diarrhea in gnotobiotic piglets using bovine antibody显示文摘 | SAIF L J CORDLE C T | 1992 | J Infect Dis1992，165，： | 1 |
| 8 | The gnotobiotic piglet as a model for studies of disease pathogenesis and immunity to hu-man rotaviruses显示文摘 | Saif L J Ward L A Yuan I | 1996 | Arch Virol Suppl1996，121，： | 1 |
| 9 | Field isolates of transmissible gastroenteritis virus differ at the molecular level from the Miller and Purdue virulent and attenuated strains and from porcine respiratory coronaviruses显示文摘 | Saif L J Jackwood D J | 1998 | J Vet Med Sci1998，60，5： | 1 |
| 10 | Molecular Characterization of Novel G5 Bovine Rotavirus Strains显示文摘 | Park S H Saif L J Jeong C | 2006 | J Clin Microbiol2006，44，11： | 1 |
| 11 | Field isolates of transmissible gastroenteritis virus differ at the molecular level from the Miller and Purdue virulent and attenuated strains and from porcine respiratory coronaviruses显示文摘 | Kwon H M Saif L J Jackwood D J | 1998 | Journal of Veterinary Medical Science1998，60，5： | 1 |
| 12 | Cell culture propagation of a coro- navirus isolated from cows with winter dysentery显示文摘 | D A Benfield L J Saif | 1990 | J Clin microbio1990，28，6： | 1 |
| 13 | Rotavirus-like,calicivirus-like,and 23-nm virus-like particles associated with diarrhea in young pigs显示文摘 | Saif L J Bohl E H Theil K W | 1980 | Journal of Clinical Microbiology1980，12，1： | 1 |
| 14 | Glenar Acousto- Optic imaging spectropolarimelry for remote sensing显示文摘 | GLENAR D A HILLMAN J J SAIF B | | App Opt 199 10，33，31： | 1 |
| 15 | Active and passive inmune re- sponses to yransmissible gastroenteritis virus(TGEV) in swine inoculated with recombinant baculovirus-expressed TGEV spike glycoprotein vaccines 显示文摘 | Shoup D I Jackwood J Saif L J | 1997 | Am J Vet Res1997，58，3： | 1 |
| 16 | Pedogenic influence on base saturation and calcium/magnesium ratios in soils of Southeastern Ohio 显示文摘 | SAIF H T SMECK N E BIGHAM J M | 1997 | Soil Science Society of America Journal1997，61，： | 1 |
| 17 | Transmissible gastroenteritis In Diseases of Swine显示文摘 | Saif L J Wesley R D | 1992 | Iowa State University Press Ames IA1992，5，： | 1 |
| 18 | Biomarkers for early detection and screening in pancreatic cancer 显示文摘 | Hoimes C J Moyer M T Saif M W | 2009 | JOP2009，10，4： | 1 |
| 19 | Pedogenic influence on base saturation and calcium/magnesium ratios in soils of Southeastern Ohio显示文摘 | Saif H T Smeck N E Bigham J M | 1997 | Soil Science Society of America Journal1997，61，2： | 1 |
| 20 | Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group(RCWG)显示文摘 | Matthijnssens J Ciarlet M McDonald S M Attoui H Banyai K Brister J R Buesa J Esona M D Estes M K Gentsch J R Iturriza-Gomara M Johne R Kirkwood C D Martella V Mertens P P Nakagomi O Parre ? o V Rahman M Ruggeri F M Saif L J Santos N Steyer A Taniguchi K Patton J T Desselherger U Van Ranst M | 2011 | Arch Virol2011，156，8： | 1 |
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