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| 1 | Ionizing Radiation Induces HMGB1 Cytoplasmic Translocation and Extracellular Release显示文摘 | Lili Wang Li He Guoqiang Bao Xin He Saijun Fan Haichao Wang | 2016 | 国际放射医学核医学杂志2016，40，2： | 4 |
| 2 | Micronuclei rate and hypoxanthine phosphoribosyl transferase mutation in radon-exposed rats显示文摘在有氡暴露的老鼠的基因变化被微原子核技术和低亚硫酸钠黄质 phosphoribosyl transferase (hprt ) 的察觉学习变化。在外部血淋巴细胞的微原子核和在吸入氡的老鼠的气管支气管的上皮的房间的率比控制的高(P <
0.05 ) 。类似的结果从 hprt 试金被获得,它在暴露氡的老鼠显示出更高的变化频率。我们的结果建议那微原子核率和 hprt 缺乏能与氡暴露为基因变化被用作简历标记。 | Fengmei Cui Saijun Fan Mingjiang Hu Jihua Nie Hongmei Li Jian Tong | 2008 | Progress in Natural Science:Materials International2008，18，10： | 3 |
| 3 | Low Concentrations of\sDiindolylmethane,a Metabolite of Indole-3-Carbinol,Protect against\sOxidative Stress in a BRCA1-Dependent Manner显示文摘 | Saijun Fan Qinghui Meng Tapas Saha | 2009 | Cancer Res2009，69，： | 1 |
| 4 | Indole-3-Carbinol Is a Negative Regulator of Estrogen显示文摘 | Auborn Saijun Fan | 2003 | Nutrtion2003，133，： | 1 |
| 5 | Commensal microbiota in the digestive tract:a review of its roles in carcinogenesis and radiotherapy显示文摘The human microflora is a complex ecosystem composed of diverse microorganisms mainly distributed in the epidermal and mucosal habitats of the entire body,including the mouth,lung,intestines,skin,and vagina.These microbial communities are involved in many essential functions,such as metabolism,immunity,host nutrition,and diseases.Recent studies have focused on the microbiota associated with cancers,particularly the oral and intestinal microbiota.Radiotherapy,the most effective cytotoxic modality available for solid tumors,contributes to the treatment of cancer patients.Mounting evidence supports that the microbiota plays pivotal roles in the efficacy and prognosis of tumor radiotherapy.Here,we review current research on the microbiota and cancer development,and describe knowledge gaps in the study of radiotherapy and the microbiota.Better understanding of the effects of the microbiome in tumorigenesis and radiotherapy will shed light on future novel prevention and treatment strategies based on modulating the microbiome in cancer patients. | Jiali Dong Yuan Li Huiwen Xiao Ming Cui Saijun Fan | 2022 | Cancer Biology & Medicine2022，19，1： | 1 |
| 6 | Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding 显示文摘 | Fan Saijun Yuan Renqi Ma Yongxian | 2001 | Oncogene2001，20，35： | 1 |
| 7 | 显示文摘 | Qinghui Meng Mei Qi Da-Zhi Chen Renqi Yuan Itzhak D. Goldberg Eliot Rosen Karen Auborn Saijun Fan | | 0，，： | 1 |
| 8 | Implanting iodine-125 seeds into rat dorsal root ganglion for neuropathic pain: neuronal microdamage without impacting hind limb motion显示文摘The use of iodine-125(125I) in cancer treatment has been shown to relieve patients' pain. Considering dorsal root ganglia are critical for neural transmission between the peripheral and central nervous systems, we assumed that 125 I could be implanted into rat dorsal root ganglia to provide relief for neuropathic pain. 125 I seeds with different radioactivity(0, 14.8, 29.6 MBq) were implanted separately through L4–5 and L5–6 intervertebral foramen into the vicinity of the L5 dorsal root ganglion. von Frey hair results demonstrated the mechanical pain threshold was elevated after implanting 125 I seeds from the high radioactivity group. Transmission electron microscopy revealed that nuclear membrane shrinkage, nucleolar margination, widespread mitochondrial swelling, partial vacuolization, lysosome increase, and partial endoplasmic reticulum dilation were visible at 1,440 hours in the low radioactivity group and at 336 hours in the high radioactivity group. Abundant nuclear membrane shrinkage, partial fuzzy nuclear membrane and endoplasmic reticulum necrosis were observed at 1,440 hours in the high radioactivity group. No significant difference in combined behavioral scores was detected between preoperation and postoperation in the low and high radioactivity groups. These results suggested that the mechanical pain threshold was elevated after implanting 125 I seeds without influencing motor functions of the hind limb, although cell injury was present. | Ling Jiao Tengda Zhang Huixing Wang Wenyi Zhang Saijun Fan Xiaodong Huo Baosen Zheng Wenting Ma | 2014 | Neural Regeneration Research2014，9，12： | 1 |
| 9 | HPV16 E6/E7 Negatively Affect Radiosensitivity of Lung Cancer Cells显示文摘 | Lu Lu Qinghui Meng Ming Cui Xiaofei Chu Shuyi Zhao Huiwen Xiao Jiali Dong Eliot Marty Rosen Saijun Fan | 2016 | 国际放射医学核医学杂志2016，40，2： | 1 |
| 10 | HMGB1 increases radiosensitivity by interacting with HDAC1显示文摘 | He Xin Meng Qinghui Meng Aimin Liu Qiang Wang Haichao Fan Saijun HeXin MengQinghui MengAimin LiuQiang WangHaichao FanSaijun | 2015 | 中华放射医学与防护杂志2015，35，1： | 0 |
| 11 | HBXIP contributes to radioresistance through NF-κB-mediated expression of XIAP in breast cancer显示文摘Objective:Hepatitis B X-interacting protein(HBXIP)plays an important role in breast tumorigenesis,tumor growth and metastasis,but its functional contribution in radioresistance remains poorly understood.As radiotherapy served as an essential adjuvant treatment,uncovering the role of HBXIP as well as its downstream molecular XIAP in radioresistance could benefit for the development of individual therapy strategy.Methods:Immunohistochemistry of 42 breast cancer tissue samples and Western blot analysis of proteins from MCF-7 and MDA-MB-231 cells exposed to fractioned doses(γ-rays)were used to identify the expression of HBXIP/XIAP in breast cancer.To verify the radioresistance effects and potential mechanism,the cells were treated with designed pCMV and siRNA of targeting genes,and then measured with MTT assay,clonogenic survival assay and flow cytometry.Furthermore,a subcutaneous xenotransplanted tumor model of breast cancer was established in nude mice to validate the radioresistization effect of HBXIP in vivo.Results:HBXIP and XIAP expression levels in breast cancer tissues were positively correlated with chemoradiotherapy resistance of breast cancer.Overexpression of HBXIP could desensitize MCF-7 and MDA-MB-231 cells to irradiation by inhibiting radiation-induced cell apoptosis,and knockdown of HBXIP in these cells had the converse response.Moreover,up-regulation of HBXIP resulted in the increase of XIAP and NF-κB levels in vitro and in vivo,while down-regulation of HBXIP led to the opposite effects.In addition,inhibition of XIAP and NF-κB abrogated the HBXIP overexpression induced radioresistization and increased cell apoptosis(25.8%augment for siRNA XIAP and 28.1%for NF-κB in MDA-MB-231 cells;25.4%augment for siRNA XIAP and 27.2%for NF–κB in MCF-7 cells).Conclusions:HBXIP enhances radioresistance of human breast cancer cells via upregulating XIAP,and targeting the HBXIP–NF–κB-XIAP pathway may be a potentially effective strategy to enhance the efficacy of radiotherapy for human breast cancer. | Xiaofei Chu Wang Zheng Qianping Chen Chen Wang Saijun Fan Chunlin Shao | 2021 | Radiation Medicine and Protection2021，2，2： | 0 |
| 12 | The protective effects of Xuebijing injection on intestinal injuries of mice exposed to irradiation显示文摘Background:Gastrointestinal(GI)injury is one of the most common side effects of radiotherapy.However,there is no ideal therapy method except for symptomatic treatment in the clinic.Xuebijing(XBJ)is a traditional Chinese medicine,used to treat sepsis by injection.In this study,the protective effects of XBJ on radiation-i nduced intestinal injury(RⅢ)and its mechanism were explored.Methods:The effect of XBJ on survival of irradiated C57BL/6 mice was monitored.Histological changes including the number of crypts and the length of villi were evaluated by H&E.The expression of Lgr5^(+)intestinal stem cells(ISCs),Ki67^(+)cells,villin and lysozymes were examined by immunohistochemistry.The expression of cytokines in the intestinal crypt was detected by RT-PCR.DNA damage and apoptosis rates in the small intestine were also evaluated by immunofluorescence.Results:In the present study,XBJ improved the survival rate of the mice after 8.0and 9.0 Gy total body irradiation(TBI).XBJ attenuated structural damage of the small intestine,maintained regenerative ability and promoted proliferation and differentiation of crypt cells,decreased apoptosis rate and reduced DNA damage in the intestine.Elevation of IL-6 and TNF-α was limited,but IL-1,TNF-β and IL-10 levels were increased in XBJ-treated group after irradiation.The expression of Bax and p53 were decreased after XBJ treatment.Conclusions:Taken together,XBJ provides a protective effect on RⅢby inhibiting inflammation and blocking p53-related apoptosis pathway. | Yinping Dong YuanYang Zhang Xinyue Wang Wenxuan Li Junling Zhang Lu Lu Hui Dong Saijun Fan Aimin Meng Deguan Li | 2022 | Animal Models and Experimental Medicine2022，5，6： | 0 |
| 13 | Bacterial communities associated with hydromedusa Gonionemus vertens in diff erent regions in Chinese coastal waters显示文摘Bacteria communities in cnidarian jellyfi sh can be harmful to many important aquaculture species,as they can be key vectors of bacterial pathogens.However,our knowledge of bacterial communities associated with jellyfi sh in culture ponds and their potential roles in the regulation of aquaculture species remains unclear.In this study,sequencing based on the bacterial 16S rRNA gene was used to investigate the composition and variation of the bacterial communities associated with hydromedusa Gonionemus vertens in sea cucumber culture ponds and natural marine environment.The associated bacterial communities of G.vertens from the culture ponds in the Yellow Sea and Bohai Sea had signifi cantly diff erent compositions,when compared with those from ambient seawater environment.Furthermore,bacterial communities associated with G.vertens had similar diversity and composition in culture ponds and natural marine environment in the Yellow Sea.There were 31 unique bacterial biomarkers identifi ed in three locations.The major communities were highly abundant in Kiloniellales,Octadecabacter,Polynucleobacter,and Polaribacter,and are related to the environmental information processing.Pathogen candidates such as Vibrionales and Chlamydiales had notably low relative abundances(<1%).The venom of the jellyfi sh was considered responsible for damage to the aquaculture.This study provides important data to help assess the impact of cnidarians-associated bacterial communities on pond aquaculture and the infl uences on material cycling and energy fl ow in marine ecosystems. | Wenjin HAO Lei WANG Fan LI Tingting SUN Saijun PENG Yongxue LI Jianmin ZHAO Zhijun DONG | 2022 | Journal of Oceanology and Limnology2022，40，4： | 0 |
| 14 | A Novel Approach for Evaluation of Food Functions and Safety Applied in RR GM Soybeans显示文摘[Objective] This study aimed to evaluate the healthy risk of genetically modified (GM) soybeans by using a novel approach for functions and safety of food.[Method] Different from traditional evaluation of substantial equivalence, three great innovations were performed in this study, involving in basic diet, evaluation approaches and principle, as well as the clarification of connotation differences between absolute and relative mass of organs. Hence a novel BDI-GS (Benefit- Damage Index and General Score) evaluation approach was established and applied in comparative evaluation between RR GM and natural soybeans. Healthy male ICR mice during linear growth were selected; experimental mice were fed with 15% RR GM soybeans and 15% natural soybeans blending maize meal diets, and control mice were fed with single maize meal diet for 13 d; the mice were dissected after collecting blood samples and perfectly obtained nine organs or tissues to record their masses and conduct statistical analyses.[Result] Plenty of matching information was obtained through simple design. The growth performance of treated mice was markedly of individual differences, some mice were thwarted due to regular intake of RR soybeans. Meanwhile, the functions and safety of RR soybeans were markedly lowered in overall nutritional and healthy effects than those of natural soybeans expressed in GS values, and presents some declines in nutrition and health of thymus, pancreas and spermary; especially, it can make thymus immune (P<0.05) in markedly lower level than that of natural soybeans.[Conclusion] Therefore, major troubles and risks of RR soybeans intake are of personal risks in different degrees, in addition, it may increase sub-health and related chronic epidemics risks, and herein it will presents certain safety issues. The creation of this novel evaluation system provides a simple and available evaluation approach for functions and potential risks revelation of food effects, and will yield far-reaching influences to safety evaluation and healthy development of GM foods, as well as public health. | Wei LONG Hao WANG Weihong LI Xiu SHEN Jiali BAI Dezhi WANG Xiaoguang WANG Saijun FAN Zewei ZHOU | 2013 | Agricultural Biotechnology2013，2，3： | 0 |
| 15 | RBAP96 Mediates Radiosensitivity of Breast Cancer Cells via Interacting with Retinoblastoma Protein显示文摘 | Junling Zhang Xiaolei Xue Qinghui Meng Lu Lu Ming Cui Saijun Fan | 2016 | 国际放射医学核医学杂志2016，40，5： | 0 |
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