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| 1 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 2 | Association of Helicobacter pylori infection with systemic inflammation in preeclampsia显示文摘 | Yusuf üstün Yaprak Engin-üstün Esra ?zkaplan Bari? Otlu Mehmet Sait Tekereko?lu | 2010 | Journal of Maternal-Fetal and Neonatal Medicine2010，，4： | 2 |
| 3 | The human sacrum and safe ap- proaches for screw placement显示文摘 | Candan A Sait N Amac K et aI | 2009 | Journal of Clinical Neuroscience2009，16，： | 1 |
| 4 | A simulated evolution approach to task matcging and scheduling in heterogeneous computing environments显示文摘 | Barada H Sait S M Baig N | 2002 | Engineering Applications of Artificial Intelligence2002，15，9： | 1 |
| 5 | Anatomical and computed tomographic analysis of C1 vertebra显示文摘 | Sait N Handan C Feridun A | 2003 | Clinical Neurology and Neurosurgery2003，105，： | 1 |
| 6 | Anatomical and computed tomographic analysis of CI vertebra显示文摘 | Sait N Handan C Feridun A | 2003 | Clinical Neurology and Neurosurgery2003，105，： | 1 |
| 7 | Ten years experience in the management of borderline ovarian tumors at Tom Baker Cancer Centre显示文摘 | Anfinan N Sait K Ghatage P | 2011 | Arch Gynecol Obstet2011，284，3： | 1 |
| 8 | The transsphenoidal removal of nonfunctioning pituitary adenoma with suprasellar extentionally staged operation显示文摘 | SAIT K KUWAYAMA N SUGITA K | 1996 | Neurosurgery1996，36，： | 1 |
| 9 | Anatomical and computed tomographic analysis of CI vertebra显示文摘 | Sait N Handan C Feridun A | 2003 | Clinical Neurology and Neurosurgery2003，105，： | 1 |
| 10 | Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridization显示文摘 | HARVEY S R SAIT S N XU Y | 1999 | Am J Pathol1999，155，： | 1 |
| 11 | Ten years experience in the management of borderline ovarian tumors at Tom Baker Cancer Centre显示文摘 | Anfinan N Sait K Ghatage P | 2011 | Arch Gynecol Obstet2011，284，73： | 1 |
| 12 | Pyrolysis and combustion kinetics of date palm biomass using thermogravimetric analysis 显示文摘 | SAIT H H HUSSAIN A SALEMA A A ANI F N | 2012 | Bioresour Technol2012，118，： | 1 |
| 13 | 显示文摘 | Saite H Ebisawa M Sakaguchi N | 1995 | Allergy Immunol1995，107，13： | 1 |
| 14 | Error analysis and motion determination of a flight simulator显示文摘 | Sait N Y Lbrahim O Chinqiz H | 2004 | Aircraft Engineering and Aexospaee Technology2004，，2： | 1 |
| 15 | The transphenoidal removalof nonfunctioning pituitary adenoma with suprasellar extentionally staged operation 显示文摘 | Sait K Kuwayama N Sugita K | 1996 | Neurosurgery1996，36，： | 1 |
| 16 | Structure and chromosomal localization of the human salivary mucin gene,MUC7显示文摘 | Bobek L A Liu J Sait S N | 1996 | Genomics1996，31，3： | 1 |
| 17 | Cervical facet dislocation:techniques for ventral reduction and stabilization 显示文摘 | Bernardo JO Edward CB Sait N | 2000 | Neurosurgey2000，92，1： | 1 |
| 18 | Immunosuppressive effect of cholera toxin B on allergic conjunctivitis model in guinea pig 显示文摘 | Sait K Shoji J Inada N | 2001 | JAN J Ophthamol2001，45，： | 1 |
| 19 | Contractile resp- onses to reactive oxygen species in the canine basilar artery in vitro: selective inhibitory effect of MCI2186, a new hydroxyl radical scavenger 显示文摘 | Tosaka M Hashiba Y Saite N | 2002 | Acta Neurochir (Wien)2002，144，12： | 1 |
| 20 | Ten years experience in the management of borderline ovarian tumors at Tom Baker Cancer Centre显示文摘 | Anfinan N Sait K Ghatage P | 2011 | Arch Gynecol Obstet2011，284，3： | 1 |
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