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	题名	作者	年代	出处	被引量
1	Expression of Interleukin-26 is upregulated in inflammatory bowel disease显示文摘AIM To investigate interleukin(IL)-26 expression in the inflamed mucosa of patients with inflammatory bowel disease(IBD) and the function of IL-26. METHODS Human colonic subepithelial myofibroblasts(SEMFs) were isolated from colon tissue surgically resected. The expression of IL-26 protein and its receptor complex was analyzed by immunohistochemistry. The gene expression induced by IL-26 was evaluated by realtime polymerase chain reaction. Intracellular signaling pathways were evaluated by immunoblotting and specific small interfering(si) RNA transfection. RESULTS The m RNA and protein expression of IL-26 were significantly enhanced in the inflamed mucosa of patients with IBD. IL-26 receptor complex was expressed in colonic SEMFs in vivo and in vitro. IL-26 stimulated the m RNA expression of IL-6 and IL-8 in colonic SEMFs. The inhibitors of mitogen-activated protein kinases and phosphoinositide 3-kinase, and si RNAs for signal transducers and activator of transcription 1/3, nuclear factor-kappa B and activator protein-1 significantly reduced the m RNA expression of IL-6 and IL-8 induced by IL-26.CONCLUSION These results suggest that IL-26 plays a role in the pathophysiology of IBD through induction of inflammatory mediators.	Makoto Fujii Atsushi Nishida Hirotsugu Imaeda Masashi Ohno Kyohei Nishino Shigeki Sakai Osamu Inatomi Shigeki Bamba Masahiro Kawahara Tomoharu Shimizu Akira Andoh	2017	World Journal of Gastroenterology2017，23，30：	8
2	Development of electronically controlled brake system for hybrid vehicle 显示文摘	Eiji Nakamura Masayuki Soga Akira Sakai	2002	SAE Paper2002，，：	1
3	Experiments on concrete filled and reinforced tubular K-joints of truss girder 显示文摘	Yoshinaga Sakai Tetsuya Hosaka Akira Isoe	2004	Journal of Constructional Steel Research2004，60，：	1
4	Fabrication technology of SiGe hetero-structures and their properties显示文摘		2005	Surface Science Report2005，59，：	1
5	Functional analysis of an α-helical antimicrobial peptide derived from a novel mouse defensin-like gene显示文摘	Akira Kawaguchi Tadaki Suzuki Takashi Kimura Naoki Sakai Tokiyoshi Ayabe Hirofumi Sawa Hideki Hasegawa	2010	Biochemical and Biophysical Research Communications2010，，4：	1
6	Prototype of SC Inverter显示文摘	Kozo Osamura Akira Sakai Taketsune Nakamura	2011	IEEE Transactions on Ap- plied Superconductivity2011，21，3：	1
7	Development of electronically controlled brake system for hybrid vehicie 显示文摘	Eiji Nakamura Masayuki Soga Akira Sakai	2002	SAE Paper2002，，：	1
8	日本化学外加剂发展的新趋势(上)	Etsuo Sakai Atsumu Ishida Akira Ohta 罗小红	2007	商品混凝土2007，0，2：	1
9	Ammonia Inhibits Proliferation and Cell Cycle Progression at S-Phase in Human Gastric Cells显示文摘	Takayoshi Matsui Yoshizumi Matsukawa Toshiyuki Sakai Keiya Nakamura Akira Aoike Keiichi Kawai	1997	Digestive Diseases and Sciences1997，，7：	1
10	Studies of surface wettability conversion on TiO2 single-crystal surfaces显示文摘	Rong Wang Nobuyuki Sakai Akira Fujishima	1999	The Journal of Physical Chemistry B1999，103，12：	1
11	Dispersion Mechanisms of Comb-type Superplasricizers Containing Grafted Poly (Ethylene Oxide) Chains显示文摘	Etsuo Sakai Akira Kawakami MasakiDaimon	2001	Macromol Syrup2001，175，3：	1
12	Evaluation of hydrogen absorption behaviour during acid-etching for surface modification of commercial pure Ti,Ti-6A1-4V and Ni-Ti superelastic alloys显示文摘	Akira Nagaoka Kenichi Yokoyama Junichi Sakai		0，，04：	1
13	Lack of Myocardial Perfusion Immediately After Successful Thrombolysis: A Predictor of Poor Recovery of Left Ventricular Function in Anterior Myocardial Infarction显示文摘	Hiroshi Ito Toshio Tomooka Noriko Sakai Hisahiro Yu Yorihiko Higashino Kenshi Fujii Tohru Masuyama Akira Kitabatake Takazo Minamino	1992	Circulation1992，，：	1
14	Molecular structure and dispersion-adsorption mechanisms of comb-type superplasticizers used in Japan显示文摘	Etsuo Sakai Kazuo Yamada Akira Ohta	2003	Journal of Advanced Concrete Technology2003，1，1：	1
15	Objective Evaluation Method of On-center Handling Characteristics 显示文摘	AKIRA Higuchi HIDEKI Sakai	2001	SAE Paper2001，，：	1
16	New trends in the development of chemical admixtures in Japan显示文摘	ETSUO Sakai ATSUMU lshida AKIRA Ohta	2006	J Adv Concr Technol2006，4，2：	1
17	Transmission Electron Microscopy of Defects in GaN Films Formed by Epitaxial Lateral Overgrowth显示文摘	Akira Sakai Haruo Sunakawa Akira Usui	1998	Applied Physics Letter1998，73，4：	1
18	日本化学外加剂发展的新趋势(下)	Etsuo Sakai Atsumu Ishida Akira Ohta 罗小红	2007	商品混凝土2007，0，3：	1
19	The present status of the Hirschberg Library 显示文摘	Akira Nakajima Shizu Sakai	1992	Documenta Ophthalmologi- ca1992，，81：	1
20	Molecular structure and dispersionadsorption mechanisms of combtype superp lasticizers used in Japan显示文摘	Kazuo Yamada Akira Ohta	2003	Journal of Advanced Concrete Technology2003，1，1：	1

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