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| 1 | Vascular endothelial growth factor trap-eye(Aflibercept) for the management of diabetic macular edema显示文摘Diabetic retinopathy(DR)is the most common cause of visual loss among working age individuals.Diabetic macular edema(DME)is an important complication of DR that affects around one third of the patients with DR.Several treatments have been approved for DME ranging from blood pressure and glycemic control to photocoagulation and more recently the use of vascular endothelial growth factor(VEGF)antagonists.The index review discusses aflibercept(EYLEA-Regeneron Pharmaceuticals,Inc.,Tarrytown,New York,NY,and Bayer Healthcare Pharmaceuticals,Berlin,Germany)in the context of other VEGF antagonists currently available for the treatment of DME.A systematic search of literature was conducted on PubMed,Scopus,and Google Scholar with no limitation on language or year of publication.Pre-clinical studies of aflibercept have shown a higher affinity of this molecule for vascular endothelial growth factor A(VEGF-A)along with a longer duration of action as compared to other VEGF antagonists.Recent clinical trials have shown visual outcome results for aflibercept to be similarly favorable as compared to other available agents with the added benefit of fewer required injections and less frequent monitoring.Aflibercept presents a potential exciting new addition to the armamentarium of current VEGF antagonists available for the treatment of DME and other retinal vascular diseases.However,further studies are indicated to confirm the role,safety,and efficacy of aflibercept for DME. | Ahmadreza Moradi Yasir Jamal Sepah Mohammad Ali Sadiq Humzah Nasir Salima Kherani Raafay Sophie Diana V Do Quan Dong Nguyen | 2013 | World Journal of Diabetes2013，4，6： | 8 |
| 2 | 药用植物内生菌对作物生长及氧化应激的作用(英文)显示文摘目的:探讨药用植物内生菌的多样性及其在种子生长和氧化应激中的作用。方法:从三种药用植物(Caralluma acutangula、Rhazya stricta和Moringa peregrina)中提取内生菌;基于18S r DNA测序和系统发育分析鉴定分离得到的内生菌株;以正常和矮化突变体水稻品系为对照,比较不同浓度的内生菌培养滤液(CF)对水稻种子的发芽和生长的影响;通过气相色谱-质谱分析CF中的有效活性成分。结论:从药用植物中共获得10种内生菌,包括茎点霉属6株、链格孢属2株、双极霉属1株和枝孢霉属1株。CF表现出剂量依赖性的生长刺激和抑制作用。与对照和其他内生菌相比,100%的茎点霉菌CF显著促进了水稻种子的发芽和生长;双极霉中的吲哚乙酸含量最高,并表现出比其更高的自由基清除和抗脂质过氧化活性;双极霉菌和茎点霉菌的类黄酮和酚类成分较高。综上所述,药用植物中存在内生菌株,其可以用于改善作物生长和减轻氧化应激。 | Abdul Latif KHAN Syed Abdullah GILANI Muhammad WAQAS Khadija AL-HOSNI Salima AL-KHIZIRI Yoon-Ha KIM Liaqat ALI Sang-Mo KANG Sajjad ASAF Raheem SHAHZAD Javid HUSSAIN In-Jung LEE Ahmed AL-HARRASI | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，2： | 6 |
| 3 | Relationship between high sensitivity C-reactive protein and angiographic severity of coronary artery disease显示文摘Background Coronary artery disease(CAD)remains a leading cause of morbidity and mortality.Cytokines play a potential role in atherosclerosis pathogenesis and progression.We investigated the association between high sensitive C-reactive protein(hs CRP)and severity of CAD.Methods CAD patients were stratified according to hs CRP cut-off value into high levels hs CRP group(≥8.4 mg/L)and low levels hs CRP group(<8.4 mg/L).Severity of CAD was assessed according to artery stenosis degree and the number of vessel involved.Statistical analysis was performed using Statistical Package for the Social Sciences(SPSS,version 23.0).Results The mean age was 60.3±11.0 years.The level of hs CRP was increased and ranged from 0.2 to 1020.0 mg/L.Biochemical risk factors and severity of CAD didn’t show significant differences between the two groups.In multivariate linear analysis,cardiac troponin I(c Tn I)and serum amyloid A(SAA)were predictors of hs CRP.As shown in receiver operating characteristic(ROC)curve analysis performed in patients with ST-segment elevation myocardial infarction(STEMI)and compared to myonecrosis biomarkers,hs CRP(area under the curve(AUC):0.905;95%CI:0.844-0.966;P<0.001)could be a powerful predictor marker in evaluating the infarct size after myocardial infarction but not better than c Tn I.Conclusions Hs CRP levels were not associated with the severity of CAD but could be useful in the evaluation of myocardial necrosis in patients with STEMI. | Nadia Bouzidi Mejdi Ben Messaoud Faouzi Maatouk Habib Gamra Salima Ferchichi | 2020 | Journal of Geriatric Cardiology2020，17，5： | 4 |
| 4 | Association of post-traumatic stress disorder and work performance: A survey from an emergency medical service, Karachi, Pakistan显示文摘BACKGROUND: The purpose of the study was to explore the association between posttraumatic stress disorder(PTSD) and work performance of emergency medical services personnel in Karachi, Pakistan.METHODS: Emergency medical service personnel were screened for potential PTSD using Impact of Event Scale-Revised(IES-R). Work performance was assessed on the basis of fi ve variables: number of late arrivals to work, number of days absent, number of days sick, adherence to protocol, and patient satisfaction over a period of 3 months. In order to model outcomes like the number of late arrivals to work, days absent and days late, negative binomial regression was applied, whereas logistic regression was applied for adherence to protocol and linear for patient satisfaction scores.RESULTS: Mean scores of PTSD were 24.0±12.2. No association was found between PTSD and work performance measures: number of late arrivals to work(RRadj 0.99; 0.98–1.00), days absent(RRadj 0.98; 0.96–0.99), days sick(RRadj 0.99; 0.98–1.00), adherence to protocol(ORadj 1.01; 0.99–1.04) and patient satisfaction(β 0.001%–0.03%) after adjusting for years of formal schooling, living status, coping mechanism, social support, working hours, years of experience and anxiety or depression.CONCLUSION: No statistically significant association was found between PTSD and work performance amongst EMS personnel in Karachi, Pakistan. | Salima Kerai Omrana Pasha Uzma Khan Muhammad Islam Nargis Asad Junaid Razzak | 2017 | World Journal of Emergency Medicine2017，8，3： | 3 |
| 5 | Datamining and salinity analysis显示文摘 | EKLUNDPW KIRKBYSD SALIMA | 1998 | Geographical Science1998，12，3： | 2 |
| 6 | Formulation Development and Antitumor Activity of a Filter-Sterilizable Emulsion of Paclitaxel显示文摘 | Panayiotis P. Constantinides Karel J. Lambert Alex K. Tustian Brian Schneider Salima Lalji Wenwen Ma Bryan Wentzel Dean Kessler Dilip Worah Steven C. Quay | 2000 | Pharmaceutical Research2000，，2： | 2 |
| 7 | Gene expression and physiological responses to salinity and water stress of contrasting durum wheat genotypes显示文摘Elucidating the relationships between gene expression and the physiological mechanisms remains a bottleneck in breeding for resistance to salinity and drought. This study related the expression of key target genes with the physiological performance of durum wheat under different combinations of salinity and irrigation. The candidate genes assayed included two encoding for the DREB(dehydration responsive element binding) transcription factors Ta DREB1 A and Ta DREB2 B, another two for the cytosolic and plastidic glutamine synthetase(Ta GS1 and Ta GS2), and one for the specific Na^+/H^+vacuolar antiporter(Ta NHX1). Expression of these genes was related to growth and different trait indicators of nitrogen metabolism(nitrogen content, stable nitrogen isotope composition, and glutamine synthetase and nitrate reductase activities), photosynthetic carbon metabolism(stable carbon isotope composition and different gas exchange traits) and ion accumulation. Significant interaction between genotype and growing conditions occurred for growth, nitrogen content, and the expression of most genes.In general terms, higher expression of Ta GS1, Ta GS2,Ta DREB2 B, and to a lesser extent of Ta NHX1 were associated with a better genotypic performance in growth, nitrogen, and carbon photosynthetic metabolism under salinity and water stress. However, Ta DREB1 A was increased in expression under stress compared with control conditions, with tolerant genotypes exhibiting lower expression than susceptible ones. | Salima Yousfi Antonio J.Marquez Marco Betti Jose Luis Araus Maria Dolores Serret | 2016 | Journal of Integrative Plant Biology2016，58，1： | 2 |
| 8 | An efficient ant algorithm for swarm - based image clustering 显示文摘 | Salima Ouadfel Mohamed Batouche | 2007 | Computer Science2007，3，3： | 1 |
| 9 | Synthesis and characterization copolymers based on styrene and partially fluorinated acrylates 显示文摘 | Salima Saidi Frederic Guittard Claude Guimon | 2006 | European Polymer Joumal2006，，42： | 1 |
| 10 | Synthesis and characterization of copolymers based on styrene and partially fluorinated acrylates 显示文摘 | Salima Saidi Frédéric Guittard Claude Guimon | 2006 | European Polymer Journal2006，42，3： | 1 |
| 11 | Application of Ulva lactuca and Systoceira stricta algae-based activated carbons to hazardous cationic dyes removal from industrial effluents显示文摘 | Salima A Benaouda B Noureddine B | 2013 | Water Research2013，47，10： | 1 |
| 12 | The Determinants of Trade Credit Demand: Survey Evidence and Empirical Analysis 显示文摘 | Salima Paul Nick Wilson | 2007 | Joumal of Accounting2007，，12： | 1 |
| 13 | Unsupervised im-age segmentation using a colony of cooperating ants显示文摘 | Salima Ouadfel Mohamed Batouche | 2002 | BMCV2002，2525，： | 1 |
| 14 | New direct torque neuro-fuzzy control based SVM-three level inverter- fed induction motor 显示文摘 | RIAD T HOCINE B SALIMA M | 2010 | Control Automation and Systems2010，8，5： | 1 |
| 15 | Fluorinated comblike homopolymers:the effect of spacer lengths on surface properties显示文摘 | Salima Saidi Frederic Guittard claude Guimon | 2005 | Journal of Polymer Science : Part A : Polymer Chemistry2005，，43： | 1 |
| 16 | Risk of acute kidney injury in patients who undergo cor-onary angiography and cardiac surgery in close succes-sion显示文摘 | Byungsoo Ko Santiago Garcia Salima Mithani | 2012 | Eur Heart J2012，33，16： | 1 |
| 17 | Gene Therapy of Human Severe Combined Immunodefieieney (SCID)-X1 Disease显示文摘 | Marina C C Salima H B Genevieve de Saint Basile | 2000 | Science2000，288，： | 1 |
| 18 | Dose-Dependent Effect of Statins on the Incidence of Acute Kidney Injury After Cardiac Surgery显示文摘 | Salima Mithani Michael Kuskowski Yelena Slinin Areef Ishani Edward McFalls Selcuk Adabag | 2011 | The Annals of Thoracic Surgery2011，，2： | 1 |
| 19 | Optimization of phenolic compound recovery and antioxidant activity of light and dark dried fig ( Ficus carica L.) varieties显示文摘 | Mostapha Bachir Bey Hayette Louaileche Salima Zemouri | 2013 | Food Science and Biotechnology2013，，6： | 1 |
| 20 | An Efficient Ant Algorithm for Swarm-Based Image Clustering 显示文摘 | Salima Ouadfel Mohamed Batouche | 2007 | Journal of Computer Science2007，3，3： | 1 |
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