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| 1 | Mitochondrial dysfunctions in neurodegenerative diseases:role in disease pathogenesis,strategies for analysis and therapeutic prospects显示文摘Fundamental organelles that occur in every cell type with the exception of mammal erythrocytes,the mitochondria are required for multiple pivotal processes that include the production of biological energy,the biosynthesis of reactive oxygen species,the control of calcium homeostasis,and the triggering of cell death.The disruption of anyone of these processes has been shown to impact strongly the function of all cells,but especially of neurons.In this review,we discuss the role of the mitochondria impairment in the development of the neurodegenerative diseases Amyotrophic Lateral Sclerosis,Parkinson's disease and Alzheimer's disease.We highlight how mitochondria disruption revolves around the processes that underlie the mitochondria's life cycle:fusion,fission,production of reactive oxygen species and energy failure.Both genetic and sporadic forms of neurodegenerative diseases are unavoidably accompanied with and often caused by the dysfunction in one or more of the key mitochondrial processes.Therefore,in order to get in depth insights into their health status in neurodegenerative diseases,we need to focus into innovative strategies aimed at characterizing the various mitochondrial processes.Current techniques include Mitostress,Mitotracker,transmission electron microscopy,oxidative stress assays along with expression measurement of the proteins that maintain the mitochondrial health.We will also discuss a panel of approaches aimed at mitigating the mitochondrial dysfunction.These include canonical drugs,natural compounds,supplements,lifestyle interventions and innovative approaches as mitochondria transplantation and gene therapy.In conclusion,because mitochondria are fundamental organelles necessary for virtually all the cell functions and are severely impaired in neurodegenerative diseases,it is critical to develop novel methods to measure the mitochondrial state,and novel therapeutic strategies aimed at improving their health. | Federica Rey Sara Ottolenghi Gian Vincenzo Zuccotti Michele Samaja Stephana Carelli | 2022 | Neural Regeneration Research2022，17，4： | 3 |
| 2 | Oxidative injury in reoxygenated and reperfused hearts 显示文摘 | Samaja M Motterlini R Santoro F | 1994 | Free Radic Bio Med1994，16，2： | 1 |
| 3 | Effects of apelin on the cardiovascular system显示文摘 | Folino A Montarolo PG Samaja M | 2015 | Heart Fail Rev2015，20，4： | 1 |
| 4 | Effects of apelin on the car- diovascular system显示文摘 | Folino A Montarolo PG Samaja M | 2015 | Heart Fail Rev2015，20，4： | 1 |
| 5 | GFP-FABD2 fusion construct allows in vivo visualization of the dynamic actin cytoskeleton in all cells of Arabidopsis seedlings显示文摘 | Voigt B Antonius C J T Jozef Samaja | 2005 | Eur J Cell Biol2005，84，： | 1 |
| 6 | Chronic hypoxia : a model for cyanotic congenital heart defects 显示文摘 | Como AF Milano G Samaja M | 2002 | J Thorac Cardiovasc Surg2002，124，1： | 1 |
| 7 | Long-Term Use of Sildenafil in the Therapeutic Management of Heart Failure显示文摘 | Marco Guazzi Michele Samaja Ross Arena Marco Vicenzi Maurizio D. Guazzi | 2007 | Journal of the American College of Cardiology2007，，： | 1 |
| 8 | Red cell function at ex- treme altitude on Mount Everest显示文摘 | Winslow RM Samaja M West JB | 1984 | J Appl Physiol Re- spir Environ Exerc Physiol1984，56，1： | 1 |
| 9 | Point:Counterpoint Comments显示文摘 | Michele Samaja Marco Guazzi | 2007 | Appl Physiol2007，，102： | 1 |
| 10 | Acid-base balance at exercise in normoxia and in chronic hypoxia Revisiting the lactate paradox显示文摘 | Cerretelli P Samaja M | 2003 | Eur J Appl Physiol2003，，90： | 1 |
| 11 | Chronic hypoxia:a model for cyanotic congenital heart defects 显示文摘 | Como AF Milano G Samaja M | 2002 | Thorae Cardiovasc Surg2002，124，1： | 1 |
| 12 | Chronic hypoxia:a model for cyanotic congenital heart defects显示文摘 | Corno AF Milano G Samaja M | 2002 | J Thorac Cardiovasc Surg2002，124，1： | 1 |
| 13 | Oxygen transport in blood at high altitude:role of the hemoglobin-oxygen affinity and impact of the phenomena related to hemoglobin allosterism and red cell function显示文摘 | Samaja M Crespi T Guazzi M | 2003 | Eur J Appl Physiol2003，90，34： | 1 |
| 14 | Hypoxia- dependent protein expression: erythropoietin 显示文摘 | Samaja M | 2001 | High Alt Med Biol2001，2，： | 1 |
| 15 | Chronic hypoxia: a model for cyanotic congenital heart defects 显示文摘 | Corno A F Milano G Samaja M | 2002 | J Thorac Cardiovasc Surg2002，124，1： | 1 |
| 16 | Long-term use of sildenafil in the therapeutic management of heart failure显示文摘 | Guazzi M Samaja M Arena R | 2007 | J Am Coll Cardiol2007，50，22： | 1 |
| 17 | Chronic and intermittent hypoxia induce different degrees of myocardial tolerance to hypoxia-induced dysfunction 显示文摘 | Milano G Corno AF Lippa S yon Segesser LK Samaja M | 2002 | Exp Biol Med ( Maywood)2002，227，6： | 1 |
| 18 | Clinical use of phosphodiesterase-5 inhibitors in cardiopulmonary diseases:from experimental evidence to clinical application显示文摘 | Guazzi M Vicenzi M Samaja M | 2009 | G Ital Cardiol (Rome)2009，10，1112： | 1 |
| 19 | Myocardial damage induced by uncontrolled veoxygenation显示文摘 | Corno AF Milano G Samaja M | 2000 | Asian Cardiovasc Thorac Surg2000，8，1： | 1 |
| 20 | Chronic hypoxia: a model for cyanotic congenital heat defects显示文摘 | Corno AF Giuseppina mitano Michete samaja | 2002 | J Thorac Cardiovas Surg2002，124，1： | 1 |
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