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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 3 | Transform-selective interference suppression algorithm for spread-spectrum communications 显示文摘 | Sami A Pertti H | 2005 | IEEE Signal Processing Letters2005，12，1： | 1 |
| 4 | Brain-derived neurotrophic factor(BDNF)polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder显示文摘 | Kaija H Sami A Martti H | | 0，，01： | 1 |
| 5 | Contribution of the antioxi- dative property of a staxanthin to its protective effect on the promo- tion of cancer metastasis in mice treated with restraint stress 显示文摘 | Kurihara H Koda H A sami S | 2002 | Life Sci2002，70，21： | 1 |
| 6 | Monitoring ultrathin film photopoly- merization of tetra-alkylepoxyporphyrin by UV-Vis spectroscopy显示文摘 | Kalle L Linda S Alexander E Sami H Risto A Nikolai T Helge L | 2009 | Journal of Polymer Science Part A: Polymer Chemistry2009，47，22： | 1 |
| 7 | Behavior of axially loaded concrete-filled circu- lar fiber-reinforced polymer tubes显示文摘 | FAM A Z SAMI H R | 2001 | ACI Structural Journal2001，98，3： | 1 |
| 8 | Acid Catalyzed Organic Transformations by Heteropoly Tungsto- phosphoric Acid Supported on MCM-41 显示文摘 | Khder Abd El R S Hassan H M A Samy El-Shall M | 2012 | Appl Catal A2012，，： | 1 |
| 9 | The effect of peppermint essential oil and fructooligosaccharides,as alternatives to virginiamycin,on growth performance,digestibility,gut morphology and immune response of male broilers显示文摘 | Khodambashi Emami N Samie A Rahmani H R | 2012 | Animal Feed Science and Technology2012，175，： | 1 |
| 10 | Spectroscopic and HPLC methods for the determination of alendronate in tablets and urine 显示文摘 | SAMI K A IMAD I H SAMER M A | 2004 | Talanta2004，64，3： | 1 |
| 11 | Horizon- tal connections for precast concrete shear walls subjected to cyclic deformations (part 1 ):mild steel connections 显示文摘 | Soudki A Khaled Rizkalla H Sami LeBlanc Bill | 1995 | PCI Journal1995，40，4： | 1 |
| 12 | Horizontal connections for precast concrete shear walls subjected to cyclic deformations ( part 2 ) : prestressed connections 显示文摘 | Soudki A Khaled Rizkalla H Sami Daikiw W Robert | 1995 | PCI Journal1995，40，5： | 1 |
| 13 | Horizontal connections for precast concrete shear wall panels under cyclic shear loading 显示文摘 | Soudki A Khaled West S Jeffrey Rizkalla H Sami | 1996 | PCI Journal1996，41，3： | 1 |
| 14 | Soft Capacity Analysis of TDMA Systems With Slow Frequency Hopping and Multiple-Beam Smart Antennas显示文摘 | Mohamed H Ahmed and Samy A Mahmoud | 2002 | IEEE Transactions on Vehicular Technology2002，51，4： | 1 |
| 15 | Factors controlling mechanisms of groundwater salinization and hydrogeochemical processes in the Quaternary aquifer of the Eastern Nile Delta, Egypt显示文摘 | Ahmed M A Abdel Samie S G Badawy H A | 2013 | Environmental Earth Science2013，68，2： | 1 |
| 16 | Mapping quantitative trait loci in inbred backcross lines of Lycopersicon pimpinellifolium (LA1589) 显示文摘 | Sami Frary A Ku H M | 2002 | Genome2002，45，6： | 1 |
| 17 | Kinetic study of dowex 50 Wx8-catalyzed esterification and hydrolysis of benzyl acetate 显示文摘 | Sami H A Sabiha Q M | 2009 | Ind Eng Chem Res2009，48，： | 1 |
| 18 | A class of proportional-integral sliding mode control with application to active suspension system显示文摘 | SamY M Osman J H S Ghani M R A | 2004 | Systems Control Lett2004，51，34： | 1 |
| 19 | Horizontal connections for precast concrete shear wall panels under cyclic shear loading 显示文摘 | Khaled A S Jeffrey S W Sami H R | 1996 | PCI Journal1996，41，3： | 1 |
| 20 | Effect of Supplemental Enzyme on Nutrient Digestibility and Performance of Broiler Chieks Fed on Diets Containing Triticale显示文摘 | Pourreza J Samie A H Rowghani E | 2007 | International Journal of Poultry Science2007，6，2： | 1 |
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