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| 1 | Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression显示文摘AIM: To evaluate the effect of resveratrol, alone and in combination with fenofibrate, on fructose-induced metabolic genes abnormalities in rats. METHODS: Giving a fructose-enriched diet(FED) to rats for 12 wk was used as a model for inducing hepatic dyslipidemia and insulin resistance. Adult male albino rats(150-200 g) were divided into a control group and a FED group which was subdivided into 4 groups, a control FED, fenofibrate(FENO)(100 mg/kg), resveratrol(RES)(70 mg/kg) and combined treatment( FENO + RES)( half the doses). A l l treatments were given orally from the 9th week till the end of experimental period. Body weight, oral glucose tolerance test(OGTT), liver index, glucose, insulin, insulin resistance(HOMA), serum and liver triglycerides(TGs), oxidative stress(liver MDA, GSH and SOD),serum AST, ALT, AST/ALT ratio and tumor necrosis factor-α(TNF-α) were measured. Additionally, hepatic gene expression of suppressor of cytokine signaling-3(SOCS-3), sterol regulatory element binding protein-1c(SREBP-1c), fatty acid synthase(FAS), malonyl Co A decarboxylase(MCD), transforming growth factor-β1(TGF-β1) and adipose tissue genes expression of leptin and adiponectin were investigated. Liver sections were taken for histopathological examination and steatosis area were determined.RESULTS: Rats fed FED showed damaged liver, impairment of glucose tolerance, insulin resistance, ox ida t ive s t re s s a nd dy s l ipide m ia. As fo r ge ne expression, there was a change in favor of dyslipidemia and nonalcoholic steatohepatitis(NASH) development. All treatment regimens showed some benefit in reversing the described deviations. Fructose caused deterioration in hepatic gene expression of SOCS-3, SREBP-1c, FAS, MDA and TGF-β1 and in adipose tissue gene expression of leptin and adiponectin. Fructose showed also an increase in body weight, insulin resistance(OGTT, HOMA), serum and liver TGs, hepatic MDA, serum AST, AST/ALT ratio and TNF-α compared to control. All treatments improved SOCS-3, FAS, MCD, TGF-β1 and leptin genes expression while only RES and FENO + RES groups showed an improvement in SREBP-1c expression. Adiponectin gene expression was improved only by RES. A decrease in body weight, HOMA, liver TGs, AST/ALT ratio and TNF-α were observed in all treatment groups. Liver index was increased in FENO and FENO + RES groups. Serum TGs was improved only by FENO treatment. Liver MDA was improved by RES and FENO + RES treatments. FENO + RES group showed an increase in liver GSH content.CONCLUSION: When resveratrol was given with half the dose of fenofibrate it improved NASH-related fructose-induced disturbances in gene expression similar to a full dose of fenofibrate. | Enas A Abd El-Haleim Ashraf K Bahgat Samira Saleh | 2016 | World Journal of Gastroenterology2016，22，10： | 5 |
| 2 | Identification and Prediction of Internet Traffic Using Artificial Neural Networks显示文摘 | JILALI A ABDELOUHAB Z SAMIRA C | | 0，，： | 1 |
| 3 | Exosomes for targeted siRNA delivery across biological barriers显示文摘 | Samir EL A Samira L Imre M | 2013 | Adv Drug Deliv Rev2013，65，3： | 1 |
| 4 | Tumor necrosis factor promotes human T-cell development in nonobese diabetic/severe combined immunodeficient mice显示文摘 | Samira S Ferrand C Peled A | 2004 | Stem Cells2004，22，6： | 1 |
| 5 | Conditioning DRASTIC model to simulate nilrate pollution case study: Hamadan - Bahar Plain 显示文摘 | Samira A Sayed F M Jahangir A K | 2011 | Environment Earth Science2011，63，6： | 1 |
| 6 | Studies on the morphology and histology of the ovary of red palm weevil female irradiated with gamma rays 显示文摘 | Samira E M Hussein F Eman A | 2010 | Joumal of Asia-Pacific Entomology2010，13，： | 1 |
| 7 | Application of SWAT model to investigate nitrate leaching in Hamadan-Bahar Watershed, Iran显示文摘 | A Samira A K Jahangir S F Mousavi | 2010 | Agriculture Ecosystems and Environment2010，139，4： | 1 |
| 8 | Hu-man CD34+CXCR4+sorted cells harbor intracellular CXCR4,which can be functionally expressed and provide NOD/SCID re-population显示文摘 | Kollet O Petit I Kahn J Samira S Dar A Peled A | 2002 | Blood2002，100，： | 1 |
| 9 | Modelling and adsorption studies of removal uranium (Ⅵ) ions on synthesised zeolite NaY显示文摘 | Fatima H Djamel N Samira A | 2013 | Desalination and Water Teratment2013，51，2830： | 1 |
| 10 | A comparison of emergence delirium scales following general anesthesia in children显示文摘 | Samira A Bajwa F David C | | 0，，08： | 1 |
| 11 | Occurrence and detection of extended-spectrum-lactamases in Klebsiella isolates in Hilla, Iraq显示文摘 | ALAA H CHARRAKH A L SAMIRA Y | 2011 | African J Biotechnol2011，10，4： | 1 |
| 12 | Applica- tion of SWAT Model to Investigate Nitrate Leaching in Hamadan-Bahar Watershed, Iran 显示文摘 | Samira A Jahangir A K Mousavi S F | 2010 | Agriculture Ecosystems& Environment2010，139，4： | 1 |
| 13 | Tobacco use by youth:a surveillance report from the Global Youth Tobacco Survey Project 显示文摘 | Charles W Leanne R Samira A | 2000 | Bulletin of World Health Organization2000，78，7： | 1 |
| 14 | Ion release fromexperimental Au-Pt-based metal-ceramic alloys显示文摘 | Johnson A Shiraishib T Samira K | 2010 | DentMater2010，26，7： | 1 |
| 15 | 2, 4- Dichlorophenoxyacetic acid ( 2,4-D ) sorption and degradation dynamics in three agricultural soils 显示文摘 | Arnaud B Samira A Michel S al | 2005 | Environ Pollut2005，1311，： | 1 |
| 16 | Overexpression of adiponectin targeted to adipose tissue in transgenic mice : impaired adipocyte differentiation显示文摘 | Isabelle B B Samira A E Anne M P | 2007 | Endocrinology2007，148，4： | 1 |
| 17 | Expression and purification of recombinant ROP1 of Toxoplasma gondii in bacteria显示文摘 | Reyhaneh M Jalal B Samira A | 2013 | Avicenna Journal of Medical Biotechnology2013，5，4： | 1 |
| 18 | Tumor Necrosis Factor Promotes Human T-Cell Development in Nonobese Diabetic/Severe Combined Immunodeficient Mice显示文摘 | Samira S Ferrand C Peled A | 2004 | Stem Cells2004，22，6： | 1 |
| 19 | Improving the radiopacity of Fe-Mn biodegradable metals by magnetron-sputtered W-Fe-Mn-C coatings:Application for thinner stents显示文摘In this exploratory work,micrometric radiopaque W-Fe-Mn-C coatings were produced by magnetron sputtering plasma deposition,for the first time,with the aim to make very thin Fe-Mn stents trackable by fluoroscopy.The power of Fe-13Mn-1.2C target was kept constant at 400 W while that of W target varied from 100 to 400 W producing three different coatings referred to as P100,P200,P400.The effect of the increased W power on coatings thickness,roughness,structure,corrosion behavior and radiopacity was investigated.The coatings showed a power-dependent thickness and W concentration,different roughness values while a similar and uniform columnar structure.An amorphous phase was detected for both P100 and P200 coatings while γ-Fe,bcc-W and W_(3)C phases found for P400.Moreover,P200 and P400 showed a significantly higher corrosion rate(CR)compared to P100.The presence of W,W_(3)C as well as the Fe amount variation determined two different micro-galvanic corrosion mechanisms significantly changing the CR of coatings,0.26±0.02,59.68±1.21 and 59.06±1.16μm/year for P100,P200 and P400,respectively.Sample P200 with its most uniform morphology,lowest roughness(RMS=3.9±0.4 nm)and good radiopacity(~6%)appeared the most suitable radiopaque biodegradable coating investigated in this study. | Samira Ravanbakhsh Carlo Paternoster Gianni Barucca Paolo Mengucci Sofia Gambaro Theophraste Lescot Pascale Chevallier a Marc-Andre Fortin Diego Mantovani | 2022 | Bioactive Materials2022，7，6： | 0 |
| 20 | 基于多价阳离子脂质——神经酰胺氨甲酰精胺的新型滴鼻流感疫苗在小鼠体内的免疫原性及保护效果研究显示文摘与注射疫苗相比,黏膜疫苗可进行滴鼻自我接种,可提供有效的全身与局部免疫力,如果突发流行可在短时间内对大量人群进行免疫接种,但同时也存在免疫原性差、需要强有力佐剂的问题。以色列Hebrew大学Joseph等尝试使用不同的脂质作为抗原传递系统。 | Joseph A Itskovitz-Cooper N Samira S 赵玉麟(摘) 徐闻青(校) | 2007 | 国际生物制品学杂志2007，30，5： | 0 |
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