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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Serum phosphate levels and mortality risk among peo- ple with chronic kidney disease显示文摘 | KESTENBAUM B SAMPSON J N RUDSER K D | 2005 | Journal of the American Society of Nephrology2005，16，2： | 1 |
| 3 | Retinal nerve fibre layer thinning associated with diabetic peripheral neuropathy显示文摘 | Shahidi AM Sampson GP Pritchard N | 2012 | Diabet Med2012，29，7： | 1 |
| 4 | The isomerization catalyzed by Brevibacterium sterolicum cholesterol oxidase proceeds stereospocifitally with one base显示文摘 | KASS I J SAMPSON N S | 1995 | Biochem Biophy Research Comm1995，206，2： | 1 |
| 5 | Antioxidant activities of carotenes and xanthophylls显示文摘 | MILLER N J SAMPSON J CANDELASI P | 1996 | FEBS Letters1996，384，： | 1 |
| 6 | Serum phosphate levels and mortality risk among people with chronic kidney disease显示文摘 | Kestenbaum B Sampson J N Rudser K D | 2005 | J Am Soc Nephrol2005，16，2： | 1 |
| 7 | Antioxidant activities of carotenes and xanthophylls显示文摘 | Miller N J Sampson J Candeias LP | 1996 | FEBS Lett1996，384，： | 1 |
| 8 | Elevated matrix metalloproteinase2 and -3 production from human idabetic dermal fibroblasts显示文摘 | Wall SJ Sampson MJ Levell N | | 0，，： | 1 |
| 9 | Isomerization, but not oxidation, is suppressed by a single point mutation, E361Q, in the reaction catalyzed by cholesterol oxidase显示文摘 | SAMPSON N S KASS I J | 1997 | J American Chemical Society1997，119，5： | 1 |
| 10 | Comparison of leaf area index estimates from tree allometrics and measured light interception显示文摘 | Smith F W Sampson D A Long J N | 1991 | Forest Science1991，37，6： | 1 |
| 11 | Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes 显示文摘 | Sampson MJ Winterbone MS Hughes JC Dozio N Hughes DA | 2006 | Diabetes Care2006，29，2： | 1 |
| 12 | Terrestrial biosphere carbon fluxes quantification of sinks and sources of CO2显示文摘 | Sampson R N Apps M Brown S | 1993 | Water Air and Soil Pollution1993，70，： | 1 |
| 13 | Antioxidant activi- ties of carotenes and xanthophylls 显示文摘 | Miller N J Sampson J Candeias L P | 1996 | FEBS Lett1996，384，3： | 1 |
| 14 | Antioxidant activities of carotenes and xanthophylls显示文摘 | Miller N J Sampson J Candeias L P | 1996 | FEBS Letters1996，384，24： | 1 |
| 15 | Terrestrial biosphere carbon fluxes quantification of sinks and sources of CO2 显示文摘 | Sampson R N Apps M Brown S | 1993 | Water Air and Soil Pollution1993，70，14： | 1 |
| 16 | Serum phosphate levels and mortality risk among people with chronic kidney disease显示文摘 | Kestenbaum B Sampson J N Rudser K D | | 0，，02： | 1 |
| 17 | Do US emergency medicine residency programs provide adequate training for bioterrorism 显示文摘 | Pesik N Keim M Sampson TR | 1999 | Ann Emerg Med1999，34，2： | 1 |
| 18 | Serum phosphate levels and mortality risk among people with chronic kidney disease显示文摘 | Kestenbaum B Sampson J N Rudser K D | 2005 | J Am Soc Nephrol2005，16，52： | 1 |
| 19 | Experimental forward mandibular displacement in sheep显示文摘 | Ma B Sampson W Fazzatari N | 2002 | Arch Oral Biol2002，47，1： | 1 |
| 20 | Antioxidant activities of carotenes and xantho-phylls显示文摘 | Miller N J Sampson J Candelas I P | 1996 | FEBS Letters1996，384，： | 1 |
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