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| 1 | Role of illness perception and self-efficacy in lifestyle modification among non-alcoholic fatty liver disease patients显示文摘AIM To describe the relationships between non-alcoholic fatty-liver disease(NAFLD) patient's disease consequences and treatment perceptions, self-efficacy, and healthy lifestyle maintenance. METHODS A cross-sectional study among 146 ultrasound diagnosed NAFLD patients who visited the fatty liver clinic at the TelAviv Medical Center. Eighty-seven of these individuals, participated in a clinical trial of physical activity and underwent fasting blood tests, analyzed at the same lab. Exclusion criteria included positivity for serum HBsA g or anti-HCV antibodies; fatty liver suspected to be secondary to hepatotoxic drugs; excessive alcohol consumption(≥ 30 g/d in men or ≥ 20 g/d in women) and positive markers of genetic or immune-mediated liver diseases. Patients were asked to complete a selfreport structured questionnaire, assembled by the Israeli Center for Disease Control. Nutrition habits were measured using six yes/no questions(0 = no, 1 = yes) adopted from the national survey questionnaire. Participants in the clinical trial completed a detailed semi-quantitative food frequency questionnaire(FFQ) reporting their habitual nutritional intake during the past year. Self-efficacy was assessed by the Self-Efficacy Scale questionnaire, emotional representation, degree of illness understanding, timeline perception, treatment perception and symptoms were measured by the Brief Illness Perception questionnaire. Illness consequences were measured by the Personal Models of Diabetes Interview questionnaire. A path analysis was performed to describe the interrelationships between the patients' illness perceptions, and assess the extent to which the data fit a prediction of nutritional habits.RESULTS The study sample included 54.1% men, with a mean age of 47.76 ± 11.68 years(range: 20-60) and mean body mass index of 31.56 ± 4.6. The average perceived nutrition habits score was 4.73 ± 1.45 on a scale between 0-6, where 6 represents the healthiest eating habits. Most of the study participants(57.2%) did not feel they fully understood what NAFLD is. Better nutritional habits were positively predicted by the degree of illness understanding(β = 0.26; P = 0.002) and selfefficacy(β = 0.25; P = 0.003). Perceptions of more severe illness consequences were related with higher emotional representation(β = 0.55; P < 0.001), which was related with lower self-efficacy(β =-0.17; P = 0.034). The perception of treatment effectiveness was positively related with self-efficacy(β = 0.32; P < 0.001). In accordance with the correlation between self-efficacy and the perceived nutrition habits score, self-efficacy was also correlated with nutrient intake evaluated by the FFQ; negatively with saturated fat(percent of saturated fat calories from total calories)(r =-0.28, P = 0.010) and positively with fiber(r = 0.22, P = 0.047) and vitamin C intake(r = 0.34, P = 0.002). In a sub analysis of the clinical trial participants, objectively measured compliance to physical activity regimen was positively correlated with the self-efficacy level(r = 0.34, P = 0.046). CONCLUSION Self-efficacy and illness understanding are major determinants of lifestyle-modification among NAFLD patients. This information can assist clinicians in improving compliance with lifestyle changes among these patients. | Shira Zelber-Sagi Shiran Bord Gali Dror-Lavi Matthew Lee Smith Samuel D Towne Jr Assaf Buch Muriel Webb Hanny Yeshua Assy Nimer Oren Shibolet | 2017 | World Journal of Gastroenterology2017，23，10： | 6 |
| 2 | Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage-role of the NADPH and xanthine oxidases显示文摘 | Samuel C Dudley JR Nyssa E | 2005 | Circulation2005，11，2： | 1 |
| 3 | Mutant PIK3CA promotes cell growth and invasion of human cancer ceils 显示文摘 | Samuels Y Diaz LA Jr Schmidt Kittler O | 2005 | Cancer Cell2005，7，6： | 1 |
| 4 | Atrial Fibrillation Increases Production of Superoxide by the Left Atrium and Left Atrial App - endage-Role of the NADPH and Xanthine Oxidases显示文摘 | Samuel C Dudley Jr Nyssa E | 2005 | Circu- lation2005，11，2： | 1 |
| 5 | EEG alphsactivity influenced by visual input and not by eye position显示文摘 | Chapman R M Samuel A Shelburne Jr | | 0，，02： | 1 |
| 6 | A review of the pathogenesis of adult peritonsillar abscess:time for a reevaluation显示文摘 | Powell EL Powell J Samuel JR | 2013 | J Antimicrob Chemother2013，68，9： | 1 |
| 7 | Nuclear matrix proteins as- sociated with DNA in situ in hormone-dependent and hormone-inde- pendent human breast cancer cell lines 显示文摘 | Spencer VA Samuel SK Davie JR | 2000 | Cancer Res2000，60，2： | 1 |
| 8 | Vibrational Spectra and Assignments for Quinoline and Isoquinoline 显示文摘 | Samuel C Wait Jr John C | 1970 | Journal of Molecular Spectroscopy1970，34，1： | 1 |
| 9 | Transforming growth fac- tor-βl (TGFI31)stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Racl/Cdc42-dependent mecha- nism~ statins with forskolin block TGFβl-induced CCN2/CT- GF expression显示文摘 | Samuel A Black Jr Trackman PC | 2008 | Biol Chem2008，283，10： | 1 |
| 10 | T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas显示文摘 | Marcal JR Samuel RO Femandes D | 2010 | J Endod2010，36，6： | 1 |
| 11 | The spectrum of 5-fluorouracil cardiotoxicity显示文摘 | Dalzell JR Samuel LM | 2009 | Anticancer Drugs2009，20，1： | 1 |
| 12 | Mutant PIK3CA promotes cell growth and invasion of human cancer cells显示文摘 | Samuels Y Diaz L A Jr Schrnidt Kittler O | 2005 | Cancer Ceil2005，7，6： | 1 |
| 13 | The spectrum of 5-fluorouracil cardiotoxicity显示文摘 | Dalzell JR Samuel LM | 2009 | Anticancer Drugs2009，20，1： | 1 |
| 14 | 24-Hour ambulatory blood pressure response to combinationvalsartan/hydrochlorothiazide and amlodipine/hydrochlorothiazide instage 2 hypertension by ethnicity:the EVALUATE study显示文摘 | Wright JT Jr Lacourciere Y Samuel R Zappe D Purkayastha D Bla-ck HR | 2010 | J ClinHypertens(Greenwich)2010，12，11： | 1 |
| 15 | Mutant PIK3CA promotes cell growth and invasion of human cancer cells显示文摘 | Samuels Y Diaz L A Jr Schmidt-Kittler O | 2005 | Cancer Cell2005，7，6： | 1 |
| 16 | Angiotensin 11induces proliferation of human cerebral artery smooth muscle cells through a basic fibroblast growth factor (bFGF) dependent mechanism显示文摘 | Zhongbiao Wang Pulipaka JR Samuel DS | 2005 | Neurosci Lett2005，373，： | 1 |
| 17 | Mutant PIK3CA pro-motes cell growth and invasion of human cancer cells 显示文摘 | Samuels Y Diaz LA Jr Schmidt-Kittler 0 | 2005 | CancerCell2005，7，6： | 1 |
| 18 | High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography/tandem mass spectrometry显示文摘 | SAMUEL A TESTINO JR GABOR P | 2003 | J Pharrn Biorned Anal2003，30，5： | 1 |
| 19 | Experience in one center of combined liver-kidney transplantation in 22 patients: incidence of graft rejection and long-term graft outcome显示文摘 | Larue JR Hiesse C Samuel D | 1997 | Transplant Proc1997，29，12： | 1 |
| 20 | Mutant PIK3CApromotes cell growth and invasion of human cancer cells 显示文摘 | Samuels Y Diaz LA Jr Schmidt-Kittler O | 2005 | Cancer Cell United States2005，7，6： | 1 |
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