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2篇 您的检索式：作者名="Sandra Buck"

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		题名	作者	年代	出处	被引量
	1	Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis显示文摘AIM:To search for further immunodominant peptides of the pyruvate dehydrogenase complex E2-component (PDC-E2) recognized by antimitochondrial antibodies (AMA) in primary biliary cirrhosis (PBC). METHODS:Sera from 95 patients with PBC were tested by enzyme-linked immunosorbent assay against 33 synthetic overlapping peptides (25 amino acids; aa) covering the entire length of the E2-subunit of PDC-E2. Furthermore,the inner lipoyl peptide 167-184 was used in an unlip oylated and a lipoylated form as well as coupled to ovalbumin. Sera from 11 AMA negative/ANA posit ive PBC patients,63 patients with other liver disorders and 22 healthy blood donors served as controls.RESULTS:Of the 95 PBC-sera,74% reacted with the peptide 475-499 and 58% with the pept ide 407-431 located within the catalytic domain of PDC-E2. Patients with other disorders or healthy controls were positive in only up to 18%. Antibodies to the unlipoylatedand lip oylated pept ide 167-184 within the inner lipoyl domain were found in only 5% and 11% of the PBC sera,respectively; using ovalbumin-coupled peptides,the incidence increased up to 57% (unlipoylated form). CONCLUSION:Peptides within the catalytic site of PDC-E2 rather than the previously reported lipoyl binding peptide 167-184 may represent major immunodomin ant epitopes recognized by AMA in PBC.	Sandra Braun Christoph Berg Sandra Buck Michael Gregor Reinhild Klein	2010	World Journal of Gastroenterology2010，16，8：	13
	2	Detection of bone metastases in patients with lung cancer: 99m Tc-MDP planar bone scintigraphy, 18 F-fluoride PET or 18 F-FDG PET/CT显示文摘	Stefan Krüger Andreas K. Buck Felix M. Mottaghy Ellen Hasenkamp Sandra Pauls Christian Schumann Thomas Wibmer Tobias Merk Vinzenz Hombach Sven N. Reske	2009	European Journal of Nuclear Medicine and Molecular Imaging2009，，：	1

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