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| 1 | Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy:A retrospective analysis of a prospective cohort显示文摘BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most frequently performed surgical procedures.Cystic stump leakage is an underestimated,potentially life threatening complication that occurs in 1%-6%of the patients.With a secure cystic duct occlusion technique during LC,bile leakage becomes a preventable complication.AIM To investigate the effect of polydioxanone(PDS)loop closure of the cystic duct on bile leakage rate in LC patients.METHODS In this retrospective analysis of a prospective cohort,the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure.Logistic regression analysis was used to develop a risk score to identify bile leakage risk.Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk.RESULTS Of the 4359 patients who underwent LC,136(3%)underwent cystic duct closure by a PDS loop.Preoperatively,loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients.In the loop closure cohort,zero(0%)bile leakage occurred compared to 59 of 4223(1.4%)clip closure patients.For patients at increased bile leakage risk(risk score≥1)rates were 1.6%and up to 13%(4/30)for clip closure patients with a risk score≥4.This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients,which was not observed for loop closure patients.CONCLUSION Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage. | Sandra C Donkervoort Lea M Dijksman Aafke H van Dijk Emile A Clous Marja A Boermeester Bert van Ramshorst Djamila Boerma | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 4 |
| 2 | Antimalarial quinolines and artemisinin inhibit endocytosis in plasmodium falciparum显示文摘 | Heinrich C Donelly A Ursula M Sandra A Joanne E Brandon W | 2004 | Antimicro Agents Chemother2004，48，： | 1 |
| 3 | Induction of cytochrome c-mediated apoptosis by amyloid β 25- 35 requires functional mitochondria 显示文摘 | Sandra M C Russell H S Catarina R O | 2002 | Brain Research2002，931，2： | 1 |
| 4 | Induction of cytochrome e-mediated apoptosis by amyloid β 25-35 requires functional mitochondria显示文摘 | Sandra M C Russell H S Catarina R O | 2002 | Brain Research2002，931，2： | 1 |
| 5 | Studieson the use of i- onic liquids as potential extraetants of phenoliccompounds and metal i- ons 显示文摘 | Sandra T M V Joana N C M Matilde M M | 2004 | Separation Science and Technology2004，39，9： | 1 |
| 6 | Enantioselective hydrosilylation with a chiral N-heterocyclic carbene complex of rhodium(I)显示文摘 | Sandra C Zhang-Presse M Herrmann W A | 2009 | A Journal of Chemical Sciences2009，64，： | 1 |
| 7 | Development of a two -colour infrared pyrometer for coal particle temperature measurements during devolatilisation显示文摘 | Frederick C Lockwood | 1998 | Fuel1998，77，9： | 1 |
| 8 | Mechanical behavior of Macadamia nut under compression loading显示文摘 | Gilberto C Braga Sandra M Couto Tetuo Hara | 1999 | J Agric Engng Res1999，72，： | 1 |
| 9 | Carcinogenicity of malachite green chloride and leucomalachite green in B6C3F1 mice and F344 rats显示文摘 | SANDRA J C PAUL W M RONALD W T | 2006 | Food and Chemical Toxicology2006，44，8： | 1 |
| 10 | A comparison of synaptophysin,chromogranin,and L2Dopa decarboxylase as markers for neuroendocrine differentiation in lung cancerlines显示文摘 | Sandra M Jensen Adi F Gazdar F C | 1990 | Cancer Rese1990，50，15： | 1 |
| 11 | IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4 + T Cells显示文摘 | Stefan Pflanz Jackie C Timans Jeanne Cheung Rency Rosales Holger Kanzler Jonathan Gilbert Linda Hibbert Tatyana Churakova Marilyn Travis Elena Vaisberg Wendy M Blumenschein Jeanine D Mattson Janet L Wagner Wayne To Sandra Zurawski Terrill K McClanahan Dan | 2002 | Immunity2002，，6： | 1 |
| 12 | Operational optimization of the utility system of an oil refinery显示文摘 | Micheletto Sandra R Carvalho Maria C A Pinto Jose M | | 0，，： | 1 |
| 13 | CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury显示文摘 | SANDRA J C PAULA M H JOHN P I | | 0，，： | 1 |
| 14 | S Simultaneous determination of copper and lead in seawater using optimised thin-mercury film electrodes in situ plated in thiocyanate media显示文摘 | HELENA M Carapuca Sandra C C Monterroso Luciana S Rocha | 2004 | Talanta2004，64，： | 1 |
| 15 | Study of novel lithium saltbased,plasticized polymer electrolytes显示文摘 | Maria M S Sandra C B | 2002 | J Power Sources2002，111，： | 1 |
| 16 | Carcinogenicity of Malachite Green Chloride and Leucomalachite Green in B6C3F1 Mice and F344 Rats显示文摘 | SANDRA J C PAUL W M RONALD W T | 2006 | Food and Chemical Toxicology2006，44，8： | 1 |
| 17 | Assessment of endostatin gene therapy for familial adenomatous polyposis related desmoid tumors 显示文摘 | Sandra C M Sarah J N Julian H | 2006 | Cancer Res2006，66，16： | 1 |
| 18 | Characterization of solid polymer electrolytes based on poly (trimethylenecrabonte) and lithium tetrafluoroborate显示文摘 | Maria M S Sandra C B Michael J S | 2004 | Electrochim Acta2004，49，： | 1 |
| 19 | Rolling circle amplifica-tion ,a powerful tool for genetic and fun< 显示文摘 | S6verine M Sandra CD Isabelle C e! : | 2008 | Antimicrob Agents Chemoth-er2008，52，9： | 1 |
| 20 | Relationships between mandibular canine calcification stages and skeletal maturity显示文摘 | Sandra C Peter H Francis M | 1993 | Am J Orthod Dentofac Orthop1993，104，： | 1 |
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