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| 1 | Association between EGF +61A/G polymorphism and gastric cancer in Caucasians显示文摘AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men. | Ana Paula Araújo Bruno M Costa Ana L Pinto-Correia Maria Fragoso Paula Ferreira Mário Dinis-Ribeiro Sandra Costa Rui M Reis Rui Medeiros | 2011 | World Journal of Gastroenterology2011，17，4： | 3 |
| 2 | Clinical decision support for drug related events: Moving towards better prevention显示文摘Clinical decision support(CDS) systems with automated alerts integrated into electronic medical records demonstrate efficacy for detecting medication errors(ME) and adverse drug events(ADEs). Critically ill patients are at increased risk for ME, ADEs and serious negative outcomes related to these events. Capitalizing on CDS to detect ME and prevent adverse drug related events has the potential to improve patient outcomes. The key to an effective medication safety surveillance system incorporating CDS is advancing the signals for alerts by using trajectory analyses to predict clinical events, instead of waiting for these events to occur. Additionally, incorporating cutting-edge biomarkers into alert knowledge in an effort to identify the need to adjust medication therapy portending harm will advance the current state of CDS. CDS can be taken a step further to identify drug related physiological events, which are less commonly included in surveillance systems. Predictive models for adverse events that combine patient factors with laboratory values and biomarkers are being established and these models can be the foundation for individualized CDS alerts to prevent impending ADEs. | Sandra L Kane-Gill Archita Achanta John A Kellum Steven M Handler | 2016 | World Journal of Critical Care Medicine2016，5，4： | 2 |
| 3 | Antimicrobial resistance profile of Actinobacillus pleuropneu moniae and Actinobacillus porcitonsillarum显示文摘 | Denise M Alexandra R Sandra L etal | 2007 | Veterinary Microbiology2007，122，： | 1 |
| 4 | Effect of culture parameters on the production of the edible mushroom Grifola frondosa (maitake) in tropical weathers显示文摘 | Sandra M B Maryeimy V L Laura L | | 0，，08： | 1 |
| 5 | Growth, fruiting and lignocel- lulolytic enzyme production by the edible mushroom Grifolafron-dosa (maitake) 显示文摘 | Sandra M Carlos E O Laura L | 2012 | World J Microbiol Biotechnol2012，28，4： | 1 |
| 6 | Distribution and fate of Escherichia coli in Lake Michigan following contamination with urban stormwater and combined sewer overflows 显示文摘 | Sandra L Erika J Morgan M | 2007 | Journal of Great Lakes Research2007，33，3： | 1 |
| 7 | TEMORA 1: a new zircon standard for Phanerozoic U-Pb geochronology显示文摘 | Lance P B Sandra L K Charlotte M A | 2003 | Chemical Geology2003，200，： | 1 |
| 8 | IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4 + T Cells显示文摘 | Stefan Pflanz Jackie C Timans Jeanne Cheung Rency Rosales Holger Kanzler Jonathan Gilbert Linda Hibbert Tatyana Churakova Marilyn Travis Elena Vaisberg Wendy M Blumenschein Jeanine D Mattson Janet L Wagner Wayne To Sandra Zurawski Terrill K McClanahan Dan | 2002 | Immunity2002，，6： | 1 |
| 9 | Measuring efficiency of sun & beach tourism destination 显示文摘 | Medina L F Ignacio G G Sandra M M | 2012 | Annals of Tourism Re- search2012，，39： | 1 |
| 10 | TEMORA 1:A New Zircon Standard for Phanerozoic U-Pb Geochronology显示文摘 | Lance P Black Sandra L Kamo Charlotte M Allen | 2003 | Chem Geol2003，200，： | 1 |
| 11 | n-3 polyunsaturated fatty acids in milk is associated to weight gain and growth in premature infants 显示文摘 | Sandra M Rosely S Cecilia L | 2009 | Lipids Health Dis2009，23，8： | 1 |
| 12 | Determination of chlormequat residues in pears and pear concentrates by Benchtop LC-ESI-MS显示文摘 | ZHAO Y LAZOU K SCHELFAUT M DE REU L SANDRA P | 2000 | Chromatographia2000，51，3： | 1 |
| 13 | TEMORA 1:a new zircon standard for Phanerozoic U-Pb geochronology显示文摘 | Lance P B Sandra L K Charlotte M A | 2003 | Chemical Geology2003，200，： | 1 |
| 14 | Hydroxycarbamide-induced changes in E/beta thalassemiared blood cells显示文摘 | Sylvia ST Elliott M Sandra L | | 0，，11： | 1 |
| 15 | TEMORA 1: a new zircon standard for Phanerozoic U-Pb geochronology显示文摘 | Lance P 13 Sandra L K Charlotte M A | 2003 | Chemical Geology2003，200，： | 1 |
| 16 | Putting evidence into practice: evidence-based intervention for fatigue during and following cancer and its treatment显示文摘 | Sandra A M Susan L B Linda E H | 2007 | Clinical Journal of Oncology Nursing2007，11，1： | 1 |
| 17 | Evolution of darkspored Myxomycetes (slime-molds): Molecules versus morphology 显示文摘 | Fiore-Donno A M Meyer M Sandra L | 2008 | Molecular Phylogenetics and Evolution2008，46，： | 1 |
| 18 | TEMORA 1: a new zircon standard for Phanerozoic U-Pb geochronology显示文摘 | Lance P B Sandra L K Charlotte M A | 2003 | Chemical Geology2003，200，12： | 1 |
| 19 | Activating networks:A progress report显示文摘 | Jonathan M Smith Kenneth L Calvert Sandra L Murphy | 1999 | Computer1999，32，4： | 1 |
| 20 | Putting evidence into practice:Evidence-based intervention for fatigue during and following cancer and its treatment显示文摘 | Sandra A M Susan L B Linda E H | | 0，，01： | 1 |
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