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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12显示文摘 | Birgit Oppmann Robin Lesley Bianca Blom Jackie C Timans Yuming Xu Brisdell Hunte Felix Vega Nancy Yu Jing Wang Komal Singh Francesca Zonin Elena Vaisberg Tatyana Churakova Man-ru Liu Daniel Gorman Janet Wagner Sandra Zurawski Yong-Jun Liu John S Abrams Ke | 2000 | Immunity2000，，5： | 2 |
| 3 | Induction of cytochrome c-mediated apoptosis by amyloid β 25- 35 requires functional mitochondria 显示文摘 | Sandra M C Russell H S Catarina R O | 2002 | Brain Research2002，931，2： | 1 |
| 4 | Induction of cytochrome e-mediated apoptosis by amyloid β 25-35 requires functional mitochondria显示文摘 | Sandra M C Russell H S Catarina R O | 2002 | Brain Research2002，931，2： | 1 |
| 5 | Role of IL-15 in immune-mediated and infectious diseases显示文摘 | Antonio D S Sandra A C Francesea V | 2011 | Cytokine Growth Factor Rev2011，22，1： | 1 |
| 6 | Small renal cell carcinomas-How dangerous are they really?Results of a large multicenter study显示文摘 | Sandra S Kerstin J Roos F C | 2014 | European Journal of Cancer2014，50，4： | 1 |
| 7 | Price formation in channels with differentiated products 显示文摘 | Sandra C Javier C Vicente S | 1998 | Internal Journal of Research in Marketing1998，15，： | 1 |
| 8 | Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses显示文摘 | Jianhua S William C H Sandra P | 2009 | Nature Structural & Molecular Biology2009，14，： | 1 |
| 9 | Differential vocalresponses to physical and mental stressors in domestic pigs ( Susscrofa) 显示文摘 | SANDRA D PETER C S BIRGER P | 2008 | Appl Anim Behav Sci2008，114，： | 1 |
| 10 | Metrological traceability of values for catalytic concentration of enzymes assigned to a calibration material显示文摘 | Francesca C Sandra C Maribel S | 2006 | Clin Chem Lab Med2006，44，3： | 1 |
| 11 | Evaluation of oxalate decarboxylase and oxalate oxidase for industrial applications 显示文摘 | Pierre C Anders S Sandra W | 2010 | Appl Biochem Biotechnol2010，161，： | 1 |
| 12 | Price Formation in Channels with Dif- ferentiated Products显示文摘 | Sandra C Javier C Vicente S | 1998 | Internal Journal of Research in Marketing1998，，15： | 1 |
| 13 | S Simultaneous determination of copper and lead in seawater using optimised thin-mercury film electrodes in situ plated in thiocyanate media显示文摘 | HELENA M Carapuca Sandra C C Monterroso Luciana S Rocha | 2004 | Talanta2004，64，： | 1 |
| 14 | Selected pesticide residues or metabolites in blood and urine specimens from a general population survey显示文摘 | Robert S Murphy Fredrick W Kutzt Sandra C Strassmant | 1983 | 48:81-861983，48，： | 1 |
| 15 | Determinants of envi- ronmental innovation adoption in the priming industry: the importance of task environment 显示文摘 | ] SANDRA R ZYGLLDOPOULOS S C | 2007 | Business Strategy and the Environment2007，16，1： | 1 |
| 16 | Benzothiadiazole-induced priming for potentiated responses to pathogen infection,wounding,and infiltration of water into leaves requires the NPR1/NIM1 gene in Arabidopsis显示文摘 | ANNEGRET K SANDRA S UWE C | 2002 | Plant Physiology2002，128，3： | 1 |
| 17 | Methods and parameters of melting curve analysis for identification of Leishmania species:A scoping review显示文摘Leishmaniasis is a set of diseases with a worldwide distribution that affects mainly economically underprivileged populations in developing countries. It has a major impact on public health, with a global cost of billions of dollars per year. The treatment and control of leishmaniasis vary according to the Leishmania species involved, which require reliable methods for species identification. Since most of the currently used methods have limitations, there is a need for assays that allow rapid, precise identification of the offending species. Real-time polymerase chain reactions in conjunction with dissociation curve analysis have been used to detect differences in the DNA composition of selected genes of Leishmania spp. Kinetoplast DNA is the main molecular target used because of its high copy number per parasite, but other targets have also been studied. As part of an effort to establish melting temperature standards for each target gene, we have reviewed the pertinent literature available in public databases, including Pub Med, Web of Science, Sci ELO and LILACS, using the keywords 'Leishmania', 'leishmaniasis', 'realtime PCR', 'melting temperature', and 'melting curve', alone or in combination. After applying eligibility criteria, 27 articles were selected for analysis. A considerable variation in the methodologies analyzed was found regarding molecular targets, standardization of the methods, reproducibility and specificity. Because of this, statistical analysis was not performed. In most cases, the methods were able to differentiate the parasite at the subgenus level or few species regardless of the target chosen. | Juliana J G Ferreira Fernanda S Nascimento Glaucia E B Marcon Eros A de Almeida Sandra C B Costa | 2021 | Asian Pacific Journal of Tropical Medicine2021，14，12： | 1 |
| 18 | Hydrolysis of eaprine and ovine milk proteins, brought about by aspartic peptidases from Silybum marianum flowers显示文摘 | SANDRA V C SOFIA V S CECILIA C | 2008 | Food Chemistry2008，106，3： | 1 |
| 19 | Study of novel lithium saltbased,plasticized polymer electrolytes显示文摘 | Maria M S Sandra C B | 2002 | J Power Sources2002，111，： | 1 |
| 20 | Characterization of solid polymer electrolytes based on poly (trimethylenecrabonte) and lithium tetrafluoroborate显示文摘 | Maria M S Sandra C B Michael J S | 2004 | Electrochim Acta2004，49，： | 1 |
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