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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Using pharmacokinetic modeling to determine the effect of drug and food on gastrointestinal transit in dogs 显示文摘 | LINNEA S SANDRA V AHMAD A S | 2011 | Journal of Pharmacological and Toxicological Methods2011，64，： | 1 |
| 3 | Design of acetylcholinesterases for biosensor applications显示文摘 | HOLGER S SANDRA V FRANCOIS V | 2003 | Biosensors and Bioelectronics2003，18，： | 1 |
| 4 | Gamma interferon release assays for detection of Mycobacterium tuberculosis in- fection显示文摘 | Pai M Claudia M D Sandra V K | 2014 | Clin Microbiol Rev2014，7，1： | 1 |
| 5 | Current Microbiology显示文摘 | Laura A Silo-Suh Eric V Stabb Sandra J Raffel | 1998 | 37(1):6-111998，37，1： | 1 |
| 6 | Role of IL-15 in immune-mediated and infectious diseases显示文摘 | Antonio D S Sandra A C Francesea V | 2011 | Cytokine Growth Factor Rev2011，22，1： | 1 |
| 7 | Quality control oroots of eleutherococcus senticosus by HPLC 显示文摘 | Sandra A Tania N Sabine V M | 2005 | Phytochem Ana2005，16，1： | 1 |
| 8 | Homogeneous oxidation of methyl isobutyrate withoxygen catalysed by metal complexes:polyoxometalates versus metalloporphyrins and meatllophthalocyanines显示文摘 | Sandra Ellis Iliev V Kozhevnikov | 2002 | J Mol Cat A:Chem2002，184，1： | 1 |
| 9 | Effect of culture parameters on the production of the edible mushroom Grifola frondosa (maitake) in tropical weathers显示文摘 | Sandra M B Maryeimy V L Laura L | | 0，，08： | 1 |
| 10 | Studieson the use of i- onic liquids as potential extraetants of phenoliccompounds and metal i- ons 显示文摘 | Sandra T M V Joana N C M Matilde M M | 2004 | Separation Science and Technology2004，39，9： | 1 |
| 11 | A novel animal model for hemangiomas;inhibition of hemangiomas develpment by angiogenesis inhibitor TNP--470显示文摘 | Sandra L Erik V Michel V | 1999 | Cancer Reserch1999，59，5： | 1 |
| 12 | The Development of a Clinical Learning Environment Scale显示文摘 | Dunn Sandra V Burnett Paul | 1997 | Journal of Advanced Nursing1997，22，6： | 1 |
| 13 | Concurrent engineering performance:In- cremental venus radical innovation显示文摘 | Valle Sandra V a zquez-Bustelo Daniel | 2009 | In- temational Journal of Production Eco- nomics2009，，1： | 1 |
| 14 | A qualitative participatory study to identify experiences of coronary heart disease patients to support the development of online self-management services显示文摘 | Sandra V Jolien J Pieter Jan S | 2013 | Int J Med Inform2013，82，12： | 1 |
| 15 | Rheology of coal water mixtures containing petroleum coke显示文摘 | Sandra V Rolando B Monica M | 1996 | Fuel1996，75，3： | 1 |
| 16 | Cloning of the mouse and human solute carrier 22a3 ( Sle22a3/SLC22a3 ) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27 显示文摘 | Sandra V Norhert S Barlow D P | 1999 | Genomics1999，55，2： | 1 |
| 17 | Undergraduate Nursing Students' Perceptions of Their Clinical Learning Environment显示文摘 | Dunn Sandra V Hansford Brian | 1997 | Journal of Advanced Nursing1997，25，6： | 1 |
| 18 | Evaluation of D-di-mer test in patients on chronic hemodialysis显示文摘 | Branimir V Sandra 0 Branko 0 | 2013 | Cardiolo-gia Croatica2013，8，7： | 1 |
| 19 | Phylogeny of the Dumontiaceae (Gigartinales,Rhodophyta) and associated families based on SSU rDNA and internal transcribed spacer sequence data显示文摘 | Sandra V T Lindstrom C Saunders G W | 2001 | J Phycol2001，37，： | 1 |
| 20 | Seasonally resolved nutrient export fluxes and filtering capacties in a macrtidal estuary 显示文摘 | Sandra A Pierre R Jean Piere V | 2009 | Journal of Marine Systems2009，78，： | 1 |
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