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| 1 | Fecal markers of inflammation used as surrogate markers for treatment outcome in relapsing inflammatory bowel disease显示文摘AIM: To evaluate fecal calprotectin (FC) as a surrogate marker of treatment outcome of relapse of inflammatory bowel disease (IBD) and, to compare FC with fecal myeloperoxidase (MPO) and fecal eosinophil protein X (EPX). METHODS: Thirty eight patients with IBD, comprising of 27 with ulcerative colitis (UC) and 11 with Crohn’s disease (CD) were investigated before treatment (inclusion), and after 4 and 8 wk of treatment. Treatment outcomes were evaluated by clinical features of disease activity and endoscopy in UC patients, and disease activity in CD patients. In addition, fecal samples were analyzed for FC by enzyme-linked immunosorbent assay (ELISA), and for MPO and EPX with radioimmunoassay (RIA). RESULTS: At inclusion 37 of 38 (97%) patients had elevated FC levels (> 94.7 μg/g). At the end of the study, 31 of 38 (82%) patients fulfilled predefined criteria of a complete response [UC 21/27 (78%); CD 10/11 (91%)]. Overall, a normalised FC level at the end of the study predicted a complete response in 100% patients, whereas elevated FC level predicted incomplete response in 30%. Normalised MPO or EPX levels predicted a complete response in 100% and90% of the patients, respectively. However, elevated MPO or EPX levels predicted incomplete response in 23% and 22%, respectively. CONCLUSION: A normalised FC level has the potential to be used as a surrogate marker for successful treatment outcome in IBD patients. However, patients with persistent elevation of FC levels need further evaluation. FC and MPO provide superior discrimination than EPX in IBD treatment outcome. | Michael Wagner Christer GB Peterson Peter Ridefelt Per Sangfelt Marie Carlson | 2008 | World Journal of Gastroenterology2008，14，36： | 9 |
| 2 | Effect on hepatitis B virus DNA levds in children infected with different genotypes显示文摘 | Sangfelt P Norder H Magnius LO Interferon - alpha 2b treament in hepatitis B carriers | 1997 | Acta Paediatr1997，86，2： | 1 |
| 3 | Molecular mechanisms underlying interferon-alpha-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins显示文摘 | Sangfelt O Erickson S Castro J | 1999 | Oncogene1999，18，18： | 1 |
| 4 | Acoustic communication in shallow water显示文摘 | Sangfelt E Lsson N Nilsson B Oberg T | 2004 | UDT Proceeding2004，，1： | 1 |
| 5 | Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer显示文摘 | Ekholm-Reed S Spruck CH Sangfelt O | 2004 | Cancer Res2004，64，3： | 1 |
| 6 | Hepatic and extrahepatic malignancies in autoimmune hepatitis. A long-term follow-up in 473 Swedish patients显示文摘 | M?rten Werner Sven Almer Hanne Prytz Stefan Lindgren Sven Wallerstedt Einar Bj?rnsson Annika Bergquist Hanna Sandberg-Gertzén Rolf Hultcrantz Per Sangfelt Ola Weiland ?ke Danielsson | 2008 | Journal of Hepatology2008，，2： | 1 |
| 7 | A low-dose intradermal hepatitis B vaccine programme in health-care workers and students is highly effective and cost saving: A retrospective follow-up survey in the clinical setting显示文摘 | Sangfelt P Uhnoo I Reichard O Weiland O | 2008 | ScandaviaJ Gastroenterol2008，43，4： | 1 |
| 8 | Molecular mechanisms underlying interferon-alpha-induced G0/G1 arrest: CKI-mediat- ed regulation of G1 Cdk-complexes and activation of pocket proteins显示文摘 | Sangfelt O Erickson S Castro J | 1999 | Oncogene1999，18，18： | 1 |
| 9 | Epidemiology and the initial presentation of autoimmune hepatitis in Sweden: A nationwide study显示文摘 | M? rten Werner Hanne Prytz Bodil Ohlsson Sven Almer Einar Bj? rnsson Annika Bergquist Sven Wallerstedt Hanna Sandberg-Gertzé n Rolf Hultcrantz Per Sangfelt Ola Weiland ? ke Danielsson | 2008 | Scandinavian Journal of Gastroenterology2008，，10： | 1 |
| 10 | Involvement of the TNK4 proteins P16 and P15 in T-lymphocytesenescence显示文摘 | Erickson S Sangfelt 0 Heyman M | 1998 | Oncogene1998，17，： | 1 |
| 11 | Apoptosis and cell growth inhibition as antitumor effector functions of interferons显示文摘 | SANGFELT O STRANDER H | 2001 | Med Oncol2001，18，： | 1 |
| 12 | L-5 and TNF-alpha participate in recruitment of eosinophILs tointestinal mucosa in ulcerative colitis显示文摘 | Lampinen M Carlson M Sangfelt P | 2001 | Dig Dis Sci2001，46，9： | 1 |
| 13 | Neutrophil and eosinophil granule proteins as markers of response to local prednisolone treatment in distal ulcerative colitis and proctitis显示文摘 | Sangfelt P Carlson M Thorn M | | 0，，： | 1 |
| 14 | Interferon-α Inhibits Proliferation in Human T Lymphocytes by Abrogation of Interleukin-2 induced Changes in Cell Cycle-regulatory Proteins显示文摘 | Sven Erickson Olle Sangfelt Juan Castro | 1999 | Cell Growth Differ1999，10，： | 1 |
| 15 | Local release of human neutrophil lipocalin (HNL),IL-8,and TNF-alpha is decreased as response to topical prednisolone treatment in distal ulcerative colitis and proctitis显示文摘 | Carlson M Thorn M | 2002 | Dig Dis Sci2002，47，9： | 1 |
| 16 | Lamivudine and fameielovir combination therapy with or without addition of interferon - alpha - 2 b for HBeAg - positive chronic hepatitis B: a pilot study显示文摘 | Sangfelt P Uhnoo I Hollander A | 2002 | Scand J Infect Dis2002，34，7： | 1 |
| 17 | Induction of apoptosis and inhibition of cell growth are independent responses to interferon-α in hematopoietic cell lines显示文摘 | Sangfelt O Erickson S Castro J | 1997 | Cell Growth Differ1997，8，： | 1 |
| 18 | Mu- tation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer显示文摘 | EKHOLM-REED S SPRUCK C H SANGFELT O | 2004 | Cancer Research2004，64，3： | 1 |
| 19 | hCDC4 gene mutations in endometrial cancer显示文摘 | Spruck CH Strohmaier H Sangfelt O | | 0，，16： | 1 |
| 20 | IFN- 2b treatment in HBV carriers, effect on HBV DNA levels in children infected with different genotypes 显示文摘 | Norder H Magnius LO | 1997 | Acta Pediat1997，86，： | 1 |
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