4篇
您的检索式：作者名="Sanjun Shi"
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| 1 | Cancer stem cells:therapeutic implications and perspectives in cancer therapy显示文摘The cancer stem cell(CSC)theory is gaining increasing attention from researchers and has become an important focus of cancer research.According to the theory,a minority population of cancer cells is capable of self-renewal and generation of differentiated progeny,termed cancer stem cells(CSCs).Understanding the properties and characteristics of CSCs is key to future study on cancer research,such as the isolation and identification of CSCs,the cancer diagnosis,and the cancer therapy.Standard oncology treatments,such as chemotherapy,radiotherapy and surgical resection,can only shrink the bulk tumor and the tumor tends to relapse.Thus,therapeutic strategies that focus on targeting CSCs and their microenvironmental niche address the ineffec-tiveness of traditional cancer therapies to eradicate the CSCs that otherwise result in therapy resistance.The combined use of traditional therapies with targeted CSC-specific agents may target the whole cancer and offer a promising strategy for lasting treatment and even cure. | Lu Han Sanjun Shi Tao Gong Zhirong Zhang Xun Sun | 2013 | Acta Pharmaceutica Sinica B2013，3，2： | 4 |
| 2 | Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis显示文摘RNAs are involved in the crucial processes of disease progression and have emerged as powerful therapeutic targets and diagnostic biomarkers.However,efficient delivery of therapeutic RNA to the targeted location and precise detection of RNA markers remains challenging.Recently,more and more attention has been paid to applying nucleic acid nanoassemblies in diagnosing and treating.Due to the flexibility and deformability of nucleic acids,the nanoassemblies could be fabricated with different shapes and structures.With hybridization,nucleic acid nanoassemblies,including DNA and RNA nanostructures,can be applied to enhance RNA therapeutics and diagnosis.This review briefly introduces the construction and properties of different nucleic acid nanoassemblies and their applications for RNA therapy and diagnosis and makes further prospects for their development. | Mengnan Zhao Rujing Wang Kunmeng Yang Yuhong Jiang Yachen Peng Yuke Li Zhen Zhang Jianxun Ding Sanjun Shi | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 2 |
| 3 | Systemic Delivery of microRNA‐34a for Cancer Stem Cell Therapy显示文摘 | Sanjun Shi Lu Han Tao Gong Zhirong Zhang Xun Sun | 2013 | Angew Chem2013，，14： | 1 |
| 4 | Unfavorable effect of small tumor size on cause-specific survival in stage IIA colon cancer, a SEER-based study显示文摘 | Yuwei Wang Changhua Zhuo Debing Shi Hongtu Zheng Ye Xu Weilie Gu Sanjun Cai Guoxiang Cai | 2015 | International Journal of Colorectal Disease2015，，1： | 1 |
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