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| 1 | Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts显示文摘Immune dysfunction is well documented during tumor progression and likely contributes to tumor immune evasion.CD81 cytotoxic T lymphocytes(CTLs)are involved in antigen-specific tumor destruction and CD41 T cells are essential for helping this CD81 T cell-dependent tumor eradication.Tumors often target and inhibit T-cell function to escape from immune surveillance.This dysfunction includes loss of effector and memory T cells,bias towards type 2 cytokines and expansion of T regulatory(Treg)cells.Curcumin has previously been shown to have antitumor activity and some research has addressed the immunoprotective potential of this plant-derived polyphenol in tumor-bearing hosts.Here we examined the role of curcumin in the prevention of tumor-induced dysfunction of T cell-based immune responses.We observed severe loss of both effector and memory T-cell populations,downregulation of type 1 and upregulation of type 2 immune responses and decreased proliferation of effector T cells in the presence of tumors.Curcumin,in turn,prevented this loss of T cells,expanded central memory T cell(TCM)/effector memory T cell(TEM)populations,reversed the type 2 immune bias and attenuated the tumor-induced inhibition of T-cell proliferation in tumor-bearing hosts.Further investigation revealed that tumor burden upregulated Treg cell populations and stimulated the production of the immunosuppressive cytokines transforming growth factor(TGF)-b and IL-10 in these cells.Curcumin,however,inhibited the suppressive activity of Treg cells by downregulating the production of TGF-b and IL-10 in these cells.More importantly,curcumin treatment enhanced the ability of effector T cells to kill cancer cells.Overall,our observations suggest that the unique properties of curcumin may be exploited for successful attenuation of tumor-induced suppression of cell-mediated immune responses. | Sankar Bhattacharyya Dewan Md Sakib Hossain Suchismita Mohanty Gouri Sankar Sen Sreya Chattopadhyay Shuvomoy Banerjee Juni Chakraborty Kaushik Das Diptendra Sarkar Tanya Das Gaurisankar Sa | 2010 | Cellular & Molecular Immunology2010，7，4： | 7 |
| 2 | Action of pelargonidin on hyperglycemia and oxidative damage in diabetic rats:Implication for glycation-induced hemoglobin modification显示文摘 | Moumita Roy Subhrojit Sen Abhay Sankar Chakraborti | 2008 | Life Scinences2008，82，21： | 1 |
| 3 | Doing better at doing good: when,why, and how consumers respond to corporate social initiatives 显示文摘 | Bhattacharya C B Sankar Sen | 2004 | California Management Review2004，47，1： | 1 |
| 4 | Does doing good always lead to doing better? Consurner reactions to corporate social responsibility显示文摘 | Sen Sankar and C B Bhattacharya | 2001 | Journal of Marketing Research2001，38，5： | 1 |
| 5 | Consumer-Company Identifieation: A Framework for Understanding Consumers' Relationships with Companies 显示文摘 | BHATTACHARYA C B SANKAR SEN | 2003 | Journal of Marketing2003，，67： | 1 |
| 6 | Doing Better at Doing Good 显示文摘 | Bhattacharya C B Sankar Sen | 2004 | Cali- fornia Management Review2004，47，1： | 1 |
| 7 | Does Doing Good always Lead to Doing Better? Consumer Reactions to Corporate Social Responsibility 显示文摘 | Sen Sankar Bhattacharya C B | 2001 | Journal of Marketing Research2001，38，2： | 1 |
| 8 | Does doing good always lead to doing better? Consumer reactions to corporate 显示文摘 | Sankar Sen C B Bhattachatya | 2001 | Journal of Marketing Research2001，5，： | 1 |
| 9 | Does Doing Good Always Lead to Doing Better? Consumer Reactions to Corporate So- cial Responsibility 显示文摘 | Sen Sankar Bhattacharya C B | 2001 | Journal of Marketing Research2001，38，2： | 1 |
| 10 | Does doing good always lead to doing better? Consumer relation to corporate social responsibility 显示文摘 | Sen Sankar | 2001 | Journal of Market Resource2001，，38： | 1 |
| 11 | Does Doing Good Always Lead to Doing Better? Consumer Reactions to Corporate Social Responsibility 显示文摘 | SANKAR SEN HATTACHARYA C B | 2001 | Journal of Marketing Research2001，38，2： | 1 |
| 12 | Doing Better at Doing Good 显示文摘 | Bhattacharya C B Sankar Sen | 2004 | California Management Review2004，，1： | 1 |
| 13 | Gradient histogram: Threshol- ding in a region of interest for edge detection显示文摘 | Debashis Sen Sankar K Pal | 2009 | Image and Vision Computing2009，28，4： | 1 |
| 14 | Consumer-Company Identification:A Framework for Understanding Consumers' Relationships with Companies 显示文摘 | Sen Sankar Bhattacharya C B | 2003 | Jour- nal of Marketing2003，67，4： | 1 |
| 15 | Consumer-com- pany identification: a framework for understanding con- sumers' relationships with companies显示文摘 | BHATTACHARYA C B SEN SANKAR | 2003 | Journal of Mar- keting2003，，67： | 1 |
| 16 | Generalized rough sets, entropy, and image ambiguity measures 显示文摘 | Debashis Sen Sankar K Pal | 2009 | IEEE Transactions on Sys- tems Man and Cybernetics2009，39，1： | 1 |
| 17 | The role of corporate social responsibility in strengthening multiple stakeholder relationships: A field experiment显示文摘 | Sankar Sen C. B. Bhattacharya Daniel Korschun | 2006 | Journal of the Academy of Marketing Science2006，，2： | 1 |
| 18 | Consumer-Company Identification:A Framework For Understanding Consumers’Relationships With Companies显示文摘 | Bhattacharya C B Sen Sankar | 2003 | Journal of Marketing2003，67，2： | 1 |
| 19 | Dose Doing Good always Lead to Doing Better? Consumer Reactions to Corporate Social Responsibility显示文摘 | Sankar Sen C.B.Bhattacharya | | 0，，02： | 1 |
| 20 | Does Doing Good Always Lead to Doing Better? Consumer Reactions to Corporate Social Responsibility显示文摘 | Sen Sankar Bhattacharya C.B | | 0，，02： | 1 |
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