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| 1 | Relationship of Helicobacterpylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study显示文摘 | Zhou Liya Lin Sanren Ding Shigang Huang Xuebiao Jin Zhu Cui Rongli Meng Lingmei Li Yuan Zhang Li Guo Changji Xue Yan Yan Xiu'e Zhang Jing | 2014 | Chinese Medical Journal2014，，8： | 28 |
| 2 | Effect of 5-Aza-2’-deoxycytidine on immune-associated proteins in exosomes from hepatoma显示文摘AIM: To study the effect of 5-Aza-2’-deoxycytidine (5-Aza-CdR) on heat shock protein 70 (HSP70), human leucocyte antigen-Ⅰ (HLA-Ⅰ) and NY-ESO-1 proteins in exosomes produced by hepatoma cells, HepG2 and Hep3B. METHODS: Exosomes derived from HepG2 and Hep3B cells treated with or without 5-aza-CdR were isolated and purified by ultrafiltration centrifugation and sucrose gradient ultracentrifugation. The number of exosomes was counted under electron microscope. Concentration of proteins in exosomes was measured by bicinchoninic acid protein assay. Expression of HSP70, HLA-Ⅰ and NY-ESO-1 proteins in exosomes was detected by Western blotting and immunoelectron microscopy. mRNA expression of p53 gene was detected by reverse transcription polymerase chain reaction.RESULTS: The mRNA expression of p53 gene was increased in both hepatoma cell lines after treatment with 5-Aza-CdR. The number of exosomes and the concentration of total proteins in exosomes were increased signifi cantly after treatment with 5-aza-CdR (P < 0.05). After treatment with 5-Aza-CdR, immunoelectron microscopy and Western blotting showed that the HSP70, HLA-Ⅰ and NY-ESO-1 proteins were increased in exosomes produced by both hepatoma cell lines. CONCLUSION: 5-aza-CdR, an inhibitor of DNA methyltransferase, can increase exosomes produced by hepatoma cells and immune-associated protein component of exosomes, which may be mediated by p53 gene upregulation and 5-Aza-CdR demethylation. | Gao-Wa Sanren | 2010 | World Journal of Gastroenterology2010，16，19： | 10 |
| 3 | Ilaprazole for the treatment of duodenal ulcer: a randomized, double-blind and controlled phase III trial显示文摘 | Ling Wang Liya Zhou Haitang Hu Sanren Lin Jielai Xia | 2012 | Current Medical Research & Opinion2012，，1： | 1 |
| 4 | A New PPI, Ilaprazole Compared With Omeprazole in the Treatment of Duodenal Ulcer: A Randomized Double-Blind Multicenter Trial显示文摘 | Ling Wang Liya Zhou Sanren Lin Haitang Hu Jielai Xia | 2011 | Journal of Clinical Gastroenterology2011，，4： | 1 |
| 5 | Effects of place- ment and orientation of body-fixed accelerometers on the as-sessment of energy expenditure during walking 显示文摘 | Bouten CV Sanren AA Verduin M | 1997 | Med Biol Eng Comput1997，35，1： | 1 |
| 6 | A generalized orthogonalalsub space projection approach to unsupervised multi - spectral image classification 显示文摘 | SanRen H Cheinlchang I | 2000 | IEEE Transaction on Geoscience and Remote Sensing2000，38，6： | 1 |
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