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| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management显示文摘 | Axel Dignass James O. Lindsay Andreas Sturm Alastair Windsor Jean-Frederic Colombel Mathieu Allez Gert D’Haens André D’Hoore Gerassimos Mantzaris Gottfried Novacek Tom ?resland Walter Reinisch Miquel Sans Eduard Stange Severine Vermeire Simon Travis Gert | 2012 | Journal of Crohn’s and Colitis2012，，10： | 4 |
| 3 | Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F显示文摘 | Sans MD DiMagno MJ DAlecy LG | 2003 | Am J Physiol Gastrointest Liver Physiol2003，285，3： | 1 |
| 4 | Systemic inflammation in non-obese children with obstructive sleep apnea 显示文摘 | Gozal D Serpero LD Sans Capdevila O | 2008 | Sleep Med2008，9，： | 1 |
| 5 | Left atrial appendage Doppler flow patterns:implications on thrombus formation 显示文摘 | Garcia-Ferndndez MA Torrecilla EG San Romdn D | 1992 | Am Heart J1992，124，： | 1 |
| 6 | Improving classification per-formance of Support Vector Machine by genetically optimizing ker-nel shape and hyper - parameters 显示文摘 | San L D Rogozan A Pecuchet J P | 2010 | Applied Intelligence2010，36，2： | 1 |
| 7 | Modeling and testing of a silica gel packed-bed system显示文摘 | San J Y Jiang G D | 1994 | Int J of Heat and Mass Transfer1994，37，8： | 1 |
| 8 | The cranioeewieal venous system in relation to cerebral venous drainage显示文摘 | San Mill6n Ruiz D Gailloud P Rifenacht DA | 2002 | Am J Neuroradiol2002，23，9： | 1 |
| 9 | Effect of the microalloying elements on nucleation of allotri- omorphic ferrite in medium carbon-manganese steels显示文摘 | Garcia de Andres C Capdevila C San Martin D | | 0，，： | 1 |
| 10 | Changes in mRNA and protein levels of proteoglyeans of the anulus fibrosus and nu- cleus pulposus duringintervertebral disc degeneration显示文摘 | Cs - Szabo G Ragasa - San Juan D Turumella V | 2002 | Spine (Phila Pa 1976)2002，27，20： | 1 |
| 11 | Ceropin A-derived petides are potent inhibitors of fungal plant pathogens显示文摘 | Cavallarin L Andreu D San Segundo B | 1998 | Mol Plant Microbe Interact1998，11，3： | 1 |
| 12 | Tuberculous pleurisy:a study of 254 patients显示文摘 | Valdés L Alvarez D San José E | 1998 | Arch Intern Med1998，158，18： | 1 |
| 13 | Peripheral blood sampling for the detection of allograft rejection:biomarker identification and validation显示文摘 | Heidt S San Segundo D Shankar S | 2011 | Transplan-tation2011，92，1： | 1 |
| 14 | Changes in the serum levels of interleukin-17/interleukin-23 during acute rejection in liver transplantation显示文摘 | Fabrega E Lopez-Hoyos M San Segundo D | 2009 | Liver transpl2009，15，6： | 1 |
| 15 | Inhibition of vascul ar smoo th muscle cell proliferation and intimal hyperplasia by gene transfer of beta-in terferon显示文摘 | San H Yang ZY | 1997 | Mol Med1997，3，9： | 1 |
| 16 | Systemic inflammation in non obese children with obstructive sleep apnea显示文摘 | Gozal D Serpero LD Sans Capdevila O | 2008 | Sleep Med2008，9，3： | 1 |
| 17 | C-reactive protein,obstructive sleep apnea,and cognitive dysfunction in school-aged children显示文摘 | Gozal D Crabtree V M Sans Capdevila O | 2007 | Am J Respir Crit Care Med2007，176，2： | 1 |
| 18 | Diagnosis of tuberculousp leurisy using the biologic parameters adenosine deaminase, lysozyme, and interferon 显示文摘 | Valdes L San Jose E Alvarez D | 1993 | Chest1993，103，： | 1 |
| 19 | Expression and function of a recombinant PDGF B gene in porcine arteries显示文摘 | Gordon D San H | 1995 | Arterioscler Thromb Vasc Biol1995，15，12： | 1 |
| 20 | Structural stiffness,dry friction coefficient,and equivalent viscous damping in a bump-type foil gas bearing显示文摘 | Rubio D San Andres L | 2007 | ASME J Eng Gas Turbines Power2007，129，2： | 1 |
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