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| 1 | Molecular determinants of response to 5-fluorouracil-based chemotherapy in colorectal cancer: The undisputable role of microribonucleic acids显示文摘5-flurouracil(5-FU)-based chemotherapy is the main pharmacological therapy for advanced colorectal cancer(CRC).Despite significant progress in the treatment of CRC during the last decades,5-FU drug resistance remains the most important cause of failure in CRC therapy.Resistance to 5-FU is a complex and multistep process.Different mechanisms including microsatellite instability,increased expression level of key enzyme thymidylate synthase and its polymorphism,increased level of 5-FU-activating enzymes and mutation of TP53 are proposed as the main determinants of resistance to 5-FU in CRC cells.Recently,microribonucleic acids(miRNA)and their alterations were found to have a crucial role in 5-FU resistance.In this regard,the miRNA-mediated mechanisms of 5-FU drug resistance reside among the new fields of pharmacogenetics of CRC drug response that has not been completely discovered.Identification of the biological markers that are related to response to 5-FU-based chemotherapy is an emerging field of precision medicine.This approach will have an important role in defining those patients who are most likely to benefit from 5-FU-based chemotherapy in the future.Thereby,the identification of 5-FU drug resistance mechanisms is an essential step to predict and eventually overcome resistance.In the present comprehensive review,we will summarize the latest knowledge regarding the molecular determinants of response to 5-FU-based chemotherapy in CRC by emphasizing the role of miRNAs. | Amirsaeed Sabeti Aghabozorgi Mostafa Moradi Sarabi Reza Jafarzadeh-Esfehani Shabnaz Koochakkhani Marziyeh Hassanzadeh Soudabeh Kavousipour Ebrahim Eftekhar | 2020 | World Journal of Gastrointestinal Oncology2020，12，9： | 3 |
| 2 | Polyunsaturated fatty acids and DNA methylation in colorectal cancer显示文摘Colorectal cancer(CRC) has been designated a major global problem, especially due to its high prevalence in developed countries. CRC mostly occurs sporadically(75%-80%), and only 20%-25% of patients have a family history.Several processes are involved in the development of CRC such as a combination of genetic and epigenetic alterations. Epigenetic changes, including DNA methylation play a vital role in the progression of CRC. Complex interactions between susceptibility genes and environmental factors, such as a diet and sedentary lifestyle, lead to the development of CRC. Clinical and experimental studies have confirmed the beneficial effects of dietary polyunsaturated fatty acids(PUFAs) in preventing CRC. From a mechanistic viewpoint, it has been suggested that PUFAs are pleiotropic agents that alter chromatin remodeling,membrane structure and downstream cell signaling. Moreover, PUFAs can alter the epigenome via modulation of DNA methylation. In this review, we summarize recent investigations linking PUFAs and DNA methylationassociated CRC risk. | Mostafa Moradi Sarabi Reza Mohammadrezaei Khorramabadi Zohre Zare Ebrahim Eftekhar | 2019 | World Journal of Clinical Cases2019，7，24： | 2 |
| 3 | A comprehensive study of the green hexafluorozirconicacid - based conversion coating 显示文摘 | Mohammadloo H E Sarabi A A Mohammad Hosseini R etal | 2014 | Progress in OrganicCoatings2014，77，2： | 1 |
| 4 | Hidrocystomas-a brief review显示文摘 | Sarabi K Khachemoune A | 2006 | Med-GenMed2006，8，3： | 1 |
| 5 | Effects of dopant concentrations on phosphorescence properties of Eu/Dy-doped Sr3MgSi2O8 显示文摘 | SABBAGH A A MOZTARZADEH A F SARABI A A | 2005 | J Lumin2005，114，： | 1 |
| 6 | Time course study of GFRα-1 expression in an animal model of stroke显示文摘 | Sarabi A Chang CF Wang Y | 2001 | Exp Neural2001，170，2： | 1 |
| 7 | Time course study of GFR alpha-1 expression in an animal model of stroke显示文摘 | SARABI A CHANG C F WANG Y | 2001 | Exp Neurology2001，170，4： | 1 |
| 8 | Heterophilic chemokine receptor interactions in chemokine signaling and biology显示文摘 | Kramp BK Sarabi A Koenen RR | 2011 | Exp Cell Res2011，317，5： | 1 |
| 9 | Incidence rates of arterial and venous thrombosis after diagnosis of systemic lupus etythematesus显示文摘 | Chang E Bobba R | 2005 | Arthritis Rheum2005，53，4： | 1 |
| 10 | Evaluation of the corrosion resistance of an epoxy-polyamide coating contai- ning different ratios of micaceous iron oxide/A1 pigment显示文摘 | Nikravesh B Ramezanzadeh B Sarabi A A | 2011 | Corrosion Science2011，53，4： | 1 |
| 11 | Gene expression patterns in mouse cortical penumbra aider focal ischemic brain injury and reperfusion 显示文摘 | Sarabi AS Shen H Wang Y | 2008 | J Neurosci Res2008，86，： | 1 |
| 12 | Time course study of GFRalpha-1 expression in an animal model of stroke显示文摘 | Sarabi A Chang CF Wang Y | 2001 | Exp Neurology2001，170，4： | 1 |
| 13 | The influence of adhesive luting systems on bond strength and failure mode of an indirect microceramic resin-based composite veneer 显示文摘 | Sarabi N Ghavamnasiri M Forooghbakhsh A | 2009 | J Con- temp Dent Pract2009，10，1： | 1 |
| 14 | Hidrocystomas-Abrief review 显示文摘 | Sarabi K Khachemoune A | 2006 | Med GenMed2006，8，3： | 1 |
| 15 | Evaluating Water Trans- port Through High Solid Polyurethane Coating using the EIS Method显示文摘 | REZAEI F SHARIF F SARABI A | 2010 | Journal of Coatings Technology and Research2010，7，： | 1 |
| 16 | A comprehensive study of the green hexafluorozirconic acid- based conversion coating 显示文摘 | Eivaz Mohammadloo H Sarabi A A Mohammad Hosseini R | 2014 | Progress in Organic Coatings2014，77，2： | 1 |
| 17 | Predictive Control of an Electromagnetic Suspension System Based on Locally Linear Model Tree and Subset Selection显示文摘 | Iman Mohammadzaman Atiye Sarabi Jamab | | Malek Ashtar University of Technology Iranian Academic Center for Education Culture and Research Alzahra Branch0，579，： | 1 |
| 18 | Incidence rates of arterial and venous thrombosis after diagnosis of systemic lupus erythematosus显示文摘 | Sarabi E Chang R Bobba D | | 0，，04： | 1 |
| 19 | 显示文摘 | Zaarei D Sarabi A A Sharif F | 2012 | Journal of Coatings Technology and Research2012，9，1： | 1 |
| 20 | N-Methylpiperidinium Chlorochromate Adsorbed on Alumina: A New Deoximation Reagent显示文摘 | Mahmood Tajbakhsh Majid M. Heravi Farajollah Mohanazadeh Siavosh Sarabi Mitra Ghassemzadeh | 2001 | Monatshefte fuer Chemie / Chemical Monthly2001，，10： | 1 |
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